Integrin alpha2

An integrin alpha subunit that primarily combines with INTEGRIN BETA1 to form the INTEGRIN ALPHA2BETA1 heterodimer. It contains a domain which has homology to collagen-binding domains found in von Willebrand factor.

Also Known As:

CD49b Antigen; GPIa; Platelet Glycoprotein Ia; VLA-2 alpha Chain; alpha2 Integrin; Antigen, CD49b; Glycoprotein Ia, Platelet; Integrin, alpha2; VLA 2 alpha Chain; alpha Chain, VLA-2; alpha2, Integrin; Antigens, CD49b; CD49b Antigens

Networked: 147 relevant articles (1 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Integrins: 14304
        Integrin alpha Chains: 91
        Integrin alpha2: 147
        human ITGA2 protein
        human ITGA2B protein

Experts

1.	Brattain, Michael G: 3 articles (03/2006 - 05/2003)
2.	Sawhney, Rajinder S: 3 articles (03/2006 - 05/2003)
3.	Santoso, S: 3 articles (11/2001 - 03/2000)
4.	Rudack, Claudia: 2 articles (01/2014 - 03/2006)
5.	Walter, Michael: 2 articles (01/2014 - 03/2006)
6.	Yang, Ren-chi: 2 articles (07/2013 - 03/2012)
7.	Zhou, Xue-li: 2 articles (07/2013 - 03/2012)
8.	Heino, Jyrki: 2 articles (12/2012 - 02/2006)
9.	Nissinen, Liisa: 2 articles (12/2012 - 02/2006)
10.	Al-Subaie, Abeer M: 2 articles (07/2008 - 01/2008)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 05/01/2002 - "These results suggest that the number of 807T alleles in alpha2 integrin is protective against atherosclerotic arterial wall thickening and the occurrence of plaque in patients with type 2 diabetes." 05/01/2002 - "The 807T allele in alpha2 integrin is protective against atherosclerotic arterial wall thickening and the occurrence of plaque in patients with type 2 diabetes." 03/01/2006 - "Platelet FcgammaRIIA expression is associated with the alpha2 integrin C807T gene polymorphism in type 2 diabetes."
2.	Ischemic Stroke 11/01/2014 - "Several studies have been examined the association of the Integrin alpha2 (ITGA2) gene-C807T (rs1126643) polymorphism with ischemic stroke susceptibility. " 04/15/2001 - "The possible role of point mutations in the platelet integrin alpha2 beta1 gene in Turkish children with ischemic stroke was evaluated in this study. " 11/30/2017 - "Association between platelet glycoprotein Ia C807T gene polymorphism and ischemic stroke: a meta-analysis in a separate ethnic group." 11/01/2012 - "These findings suggest that there is no role of GPIa C807T polymorphisms in the development of young first-ever ischemic stroke in Chinese Han Population." 01/01/2008 - "Genetic variants in the gene encoding integrin alpha2 (ITGA2) have been reported to be associated with an increased risk for ischemic stroke. "
3.	Acute Coronary Syndrome 01/01/2008 - "In conclusion, this study shows the 807T/873A allele of the GpIa gene is an independent risk factor for the RPR on dual antiplatelet treatment, and extends, in a larger acute coronary syndrome population, the observation that the 807T/873A allele is associated with higher platelet reactivity." 03/01/2004 - "This study investigated the correlation between acute coronary syndrome (ACS) and 807 C/T dimorphism of GPIa gene in Chinese of Han ethnicity. " 01/01/2003 - "During the last decade platelet glycoprotein Ia and IIIa polymorphisms have been studied intensely in order to clarify their contribution to the thrombotic process and moreover their role in acute coronary syndromes. " 07/01/2001 - "The C807T/G873A polymorphism in the platelet glycoprotein Ia gene and the risk of acute coronary syndrome in the Italian population." 02/01/2007 - "It was the aim of the present study to assess whether the response to aspirin and clopidogrel may be influenced by the 807 C/T polymorphism of the glycoprotein Ia (GpIa) gene in patients with non-ST elevation acute coronary syndrome (NSTE ACS). "
4.	Myocardial Infarction 09/01/2005 - "In this study we aimed to determine the frequency of GPIa C807T/G873A genotype in patients with myocardial infarction (MI) and healthy controls in Turkish population and association between these dimorphisms and risk factors of MI. " 05/16/2006 - "Genetic polymorphisms of platelet glycoprotein Ia and the risk for premature myocardial infarction: effects on the release of sCD40L during the acute phase of premature myocardial infarction." 08/01/2005 - "1. To determine the frequency of C807T polymorphism of the GPIa gene in young survivors of myocardial infarction (MI) and 2. to evaluate the relationship between the intensity of CAD in the coronary angiography examination and the 807C/T genetic status of the patients. " 02/01/2002 - "The T807 allele of the GPIa gene alone or in combination with the PlA2 allele had no major effect on premature myocardial infarction risk." 02/01/2001 - "The 807T and 873A variants of platelet glycoprotein Ia gene are common and in a perfect linkage in the Japanese population, but it appears unlikely that the 807T (873A) variant represents a useful marker of increased risk for myocardial infarction."
5.	Coronary Artery Disease (Coronary Atherosclerosis) 05/31/2007 - "Lack of association between the platelet glycoprotein Ia C807T gene polymorphism and coronary artery disease: a meta-analysis." 08/01/2005 - "Our results may question the potential role of C807T the GPIa anomaly as a single genetic abnormality predisposing young men to coronary artery disease." 06/30/2004 - "In this study, we investigated the role of GPIa, HPA-1 and HPA-3 polymorphisms as putative risk factors for myocardial infarction (MI) and the extent of coronary artery disease. " 06/30/2004 - "Association of the gene polymorphisms of platelet glycoprotein Ia and IIb/IIIa with myocardial infarction and extent of coronary artery disease in the Korean population." 05/15/2000 - "Platelet glycoprotein Ia gene dimorphism alpha2-807 in malignant arrhythmia in coronary artery disease."

Related Drugs and Biologics

1.	Platelet Membrane Glycoproteins
2.	Antibodies
3.	Glycoproteins (Glycoprotein)
4.	Autoantibodies
5.	Inosine Triphosphate (ITP)
6.	Aspirin (Acetylsalicylic Acid)
7.	Integrin beta3 (GPIIIa)
8.	Integrins
9.	Fibrinogen (Factor I)
10.	Integrin alpha2beta1

Related Therapies and Procedures

1.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
2.	Percutaneous Coronary Intervention
3.	Surgical Decompression