Fibrinogen Receptors

Receptors that bind FIBRINOGEN through distinct adhesive sequences on the fibrinogen molecule. Although MACROPHAGE-1 ANTIGEN is considered an important signaling molecule for fibrinogen interaction, a variety of INTEGRINS from all three major families, (beta1, beta2, and beta3) have been shown to bind fibrinogen.

Also Known As:

Networked: 127 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Carloni, Silvia: 2 articles (01/2020 - 06/2013)
2.	Lucchesi, Alessandro: 2 articles (01/2020 - 06/2013)
3.	Di Minno, Giovanni: 2 articles (07/2017 - 04/2016)
4.	Poon, Man-Chiu: 2 articles (07/2017 - 04/2016)
5.	Zotz, Rainer: 2 articles (07/2017 - 04/2016)
6.	d'Oiron, Roseline: 2 articles (07/2017 - 04/2016)
7.	Sirotkina, O V: 2 articles (01/2013 - 01/2007)
8.	Alves, Christina S: 2 articles (01/2009 - 04/2008)
9.	Konstantopoulos, Konstantinos: 2 articles (01/2009 - 04/2008)
10.	Karhunen, Pekka J: 2 articles (01/2007 - 07/2006)

Related Diseases

1.	Thrombosis (Thrombus) 11/01/2003 - "alpha(IIb)beta(3) is a platelet-specific fibrinogen receptor that is critical for thrombosis and hemostasis. " 12/16/1999 - "Although intravenously administered antiplatelet fibrinogen receptor (GPIIb/IIIa) antagonists have become established in the acute-care clinical setting for the prevention of thrombosis, orally administered drugs for chronic use are still under development. " 10/10/1997 - "The platelet fibrinogen receptor GpIIb-IIIa is currently considered a target of choice for drugs used in the prevention and treatment of thrombosis. " 07/01/1994 - "Inhibition of thrombosis by a selective fibrinogen receptor antagonist without effect on bleeding time." 08/29/2023 - "Our in vitro feasibility results indicate that ReoPro-conjugated SPIONS (Tx@ReoPro) can effectively prevent thrombus growth by inhibiting fibrinogen receptors (GPIIbIIIa) on the platelet surface, and simultaneously, it can also be visible through non-invasive magnetic resonance imaging (MRI) for potential reporting of the real-time thrombus status."
2.	Thrombocytopenia (Thrombopenia) 01/01/2012 - "The origin of thrombocytopenia in this condition remains unclear and this may represent an interesting natural model to get further insight into the role of the megakaryocyte fibrinogen receptor in megakaryopoiesis. " 07/15/1999 - "Most clinical trials with fibrinogen receptor antagonists (FRAs) have been associated with thrombocytopenia. " 12/01/2005 - "Our observations indicate that 1) HPA-1a alloabs are heterogeneous in their ability to interfere with fibrinogen binding, and 2) inhibition of the alphaIIbbeta3 fibrinogen receptor by HPA-1a alloabs may contribute to pronounced bleeding in patients with alloimmune thrombocytopenia." 07/01/1994 - "Probably the combination of anti-HPA-1b and anti-HPA-2a alloantibodies, directed against the platelet fibrinogen receptor and the von Willebrand receptor, respectively, induced a thrombocytopenia and a thrombocytopathy." 06/01/2004 - "Acute thrombocytopenia is a recognized side-effect of treatment with the fibrinogen receptor antagonist, abciximab, a chimeric (human/mouse) Fab fragment. "
3.	Neoplasms (Cancer) 01/01/2020 - "This study was conducted to evaluate the expression of fibrinogen receptors on platelets of Philadelphia-negative chronic myeloproliferative neoplasm (MPN) patients. " 10/01/2001 - "We found that the fibrinogen receptor (GPIIb/IIIa, alpha2bbeta3) is activated within irradiated tumor blood vessels. " 01/01/2020 - "Unexpected low expression of platelet fibrinogen receptor in patients with chronic myeloproliferative neoplasms: how does it change with aspirin?" 01/01/2003 - "Immunohistochemical staining of irradiated tumors showed accumulation of fibrinogen receptor alpha(2b)beta(3) integrin. " 07/01/2006 - "To explore whether genetic polymorphisms in platelet receptors known to be associated with platelet activity have any association with haematogenous metastases in renal cell carcinoma (RCC), as platelets and their fibrinogen receptors may be central to haematogenous cancer spread, in addition to various adhesive proteins on both platelets and tumour cells on themselves. "
4.	Coronary Thrombosis 05/30/2003 - "The Pl(A2) polymorphism of the glycoprotein IIIa subunit of the fibrinogen receptor (GPIIb-IIIa) has been reported by some studies to be associated with an increased risk of coronary thrombosis. " 10/01/2000 - "Platelet glycoprotein (GP)IIb/IIIa fibrinogen receptors play a key role in coronary thrombosis and MI. " 01/01/1991 - "Second, in experimental models of coronary thrombosis, reocclusion after thrombolysis can be prevented or markedly delayed by antiplatelet interventions, such as administration of a monoclonal antibody against the platelet glycoprotein (GP) IIb and IIIa--the putative fibrinogen receptor on platelet membrane whose exposure seems to be an obligatory step for platelet aggregation to occur.(ABSTRACT TRUNCATED AT 250 WORDS)"
5.	Acute Coronary Syndrome 06/01/1998 - "The benefits of direct thrombin inhibitors, platelet fibrinogen receptor antagonists, and low-molecular-weight heparins in the treatment of acute coronary syndromes have been demonstrated in randomized clinical trials." 01/01/2011 - "Interaction between aggregating activity of platelets and glycoprotein (GP) IIb/IIIa (fibrinogen receptor) content on their surface was investigated in patients with acute coronary syndrome (ACS). "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Blood Coagulation Factors (Coagulation Factor)
3.	Subtilisin
4.	Fluorescein (Funduscein)
5.	Fluorescein-5-isothiocyanate (FITC)
6.	Thrombin
7.	Liposomes (Liposome)
8.	arginyl-glycyl-aspartyl-serine
9.	isothiocyanic acid
10.	Glycoproteins (Glycoprotein)

Related Therapies and Procedures

1.	Stents
2.	Transplantation
3.	Therapeutics
4.	Microspheres (Microsphere)
5.	Cardiopulmonary Bypass (Heart-Lung Bypass)