Poly(A)-Binding Protein I

A poly(A) binding protein that has a variety of functions such as mRNA stabilization and protection of RNA from nuclease activity. Although poly(A) binding protein I is considered a major cytoplasmic RNA-binding protein it is also found in the CELL NUCLEUS and may be involved in transport of mRNP particles.

Also Known As:

PAB1 Poly(A) Binding Protein; PABP1 Protein; PABPC1 Protein; Poly(A)-Binding Protein, Cytoplasmic 1; p70 Poly(A) Binding Protein

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - RNA-Binding Proteins: 3262
      - Poly(A)-Binding Proteins: 85
        Poly(A)-Binding Protein I: 8
        human PABPN1 protein
        mouse PABPN1 protein
  - Nucleoproteins: 1870
    - RNA-Binding Proteins: 3262
      - Poly(A)-Binding Proteins: 85
        Poly(A)-Binding Protein I: 8
        human PABPN1 protein
        mouse PABPN1 protein

Experts

1.	Cao, Yongchang: 1 article (01/2022)
2.	Han, Zhenling: 1 article (01/2022)
3.	She, Gaoli: 1 article (01/2022)
4.	Wei, Xiaona: 1 article (01/2022)
5.	Wu, Tingting: 1 article (01/2022)
6.	Xu, Zhichao: 1 article (01/2022)
7.	Xue, Chunyi: 1 article (01/2022)
8.	Zheng, Shumei: 1 article (01/2022)
9.	Chen, Yonghong: 1 article (01/2021)
10.	Feng, Cong: 1 article (01/2021)

Related Diseases

1.	Carcinogenesis 01/01/2021 - "Poly (A) binding protein cytoplasmic 1 (PABPC1) plays a crucial role in the regulation of RNA polyadenylation, translation initiation, and mRNA stability and may be involved in tumorigenesis. " 03/01/2006 - "Poly A binding protein, cytoplasmic 1 (PABPC1) plays a role in post-transcriptional control of mRNA and may be involved in tumorigenesis. "
2.	Infections 01/01/2022 - "Here, we found that the infection of PEDV downregulated the expression of poly(A)-binding protein cytoplasmic 1 (PABPC1) at the later infection stage in Vero cells. " 06/04/2020 - "Here, we showed, for the first time, that SVV infection cleaved poly(A) binding protein cytoplasmic 1 (PABPC1). "
3.	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 01/01/2019 - "Leukemic presentation of ALK-positive anaplastic large cell lymphoma with a novel partner, poly(A) binding protein cytoplasmic 1 (PABPC1), responding to single-agent crizotinib."
4.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2021 - "This research aimed to probe the expression characteristics of poly(A)-binding protein cytoplasmic 1 (PABPC1) and its role on the phenotype of ovarian cancer (OC) cells and to further investigate the possible underlying mechanism. "
5.	Neoplasm Metastasis (Metastasis) 01/01/2023 - "Poly(A)-binding protein cytoplasmic 1 (PABPC1), an RNA-binding protein, was found to enhance the stability of PAK1 mRNA, leading to EMT progress and GC metastasis. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Proteasome Endopeptidase Complex (Proteasome)
3.	RNA-Binding Proteins (RNA-Binding Protein)
4.	RNA (Ribonucleic Acid)
5.	Ribosomal Proteins (Ribosomal Protein)
6.	Antigens
7.	Crizotinib