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Integrin alpha5beta1

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An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.

Also Known As:

Fibronectin Receptor; Integrin alpha-5 beta-1; Platelet Glycoprotein Ic/IIa; VLA-5; VLA-5 Receptors; Glycoprotein Ic/IIa, Platelet; Ic/IIa, Platelet Glycoprotein; Integrin alpha 5 beta 1; Receptor, Fibronectin; Receptors, VLA 5; VLA 5 Receptors; alpha-5 beta-1, Integrin; alpha5beta1, Integrin; beta-1, Integrin alpha-5; Receptors, VLA-5

Networked: 299 relevant articles (5 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zahn, Grit: 9 articles (02/2010 - 06/2006)
2.	Stragies, Roland: 6 articles (02/2010 - 06/2006)
3.	Livant, Donna L: 5 articles (10/2011 - 11/2005)
4.	Omura, Yoshiaki: 5 articles (01/2010 - 01/2005)
5.	Dontenwill, Monique: 4 articles (08/2013 - 06/2006)
6.	Zeng, Zhao-Zhu: 4 articles (10/2011 - 08/2006)
7.	Vossmeyer, Dörte: 4 articles (02/2010 - 09/2007)
8.	Vossmeyer, Doerte: 4 articles (12/2009 - 06/2006)
9.	Martin, Sophie: 3 articles (08/2013 - 06/2006)
10.	Staszewski, Evan D: 3 articles (10/2011 - 03/2010)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2011 - "Our studies suggest that tumor cell-derived TNFα constitutes a tumor microenvironment signal that promotes differentiation of tumor-associated monocytes toward a proangiogenic/provasculogenic myeloid-endothelial phenotype via upregulation of the fibronectin receptor α(5)β(1)." 11/01/2015 - "α5β1 Integrin, a fibronectin receptor, is becoming a pertinent therapeutic target and a promising prognostic biomarker for cancer patients. " 01/01/2013 - "This review highlights the current knowledge about α5β1 integrin, also called the fibronectin receptor, in solid tumors. " 01/01/2013 - "Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors." 12/01/2009 - "Antagonists of human integrin alpha5beta1 have therapeutic potential as anti-angiogenic agents in cancer and diseases of the eye. "
2.	Carcinoma (Carcinomatosis) 03/25/1992 - "RGD is highly effective in the presence of Ca2+, somewhat less effective in Mg2+, and virtually inactive in Mn2+. These results suggest that alpha v beta 6 functions as an RGD-dependent fibronectin receptor in FG-2 carcinoma cells. " 01/01/2005 - "This study evaluated the direct biologic effect of cross-linking alpha5beta1 integrin on cell cycle progression and apoptosis in two human urothelial carcinoma cell lines. " 01/01/2011 - "[Implication of integrin alpha5beta1 in human breast carcinoma apoptosis and drug resistance]." 07/01/2010 - "Thus, Le(Y) in integrin alpha5beta1 was thought to be involved in the enhanced cell adhesion properties of malignant ovarian carcinomas." 07/01/2010 - "Enhancement of the adhesive and spreading potentials of ovarian carcinoma RMG-1 cells due to increased expression of integrin alpha5beta1 with the Lewis Y-structure on transfection of the alpha1,2-fucosyltransferase gene."
3.	Infection 01/01/2013 - "Additionally, we analyzed its effect on host cellular functions linked to the host receptor fibronectin, such as migration, adhesion and matrix formation in vitro, to evaluate potential side effects prior to advancing our studies to in vivo infection models. " 09/01/2006 - "In this report, we demonstrate that integrin alpha5beta1 serves as an alternative coreceptor for AAV2 infection in human embryonic kidney 293 cells. " 09/01/1996 - "To evaluate the expression of the alpha 5 beta 1 integrin fibronectin receptor (FNR), which mediates several processes, including phagocytosis, cell motility and the immune response, on T lymphocytes of patients with HIV-1 infection. " 09/01/1996 - "Expression of the alpha 5 beta 1 fibronectin receptor on T lymphocytes of patients with HIV-1 infection." 05/01/1994 - "Levels of circulating fibronectin receptor in adult and pediatric patients with human immunodeficiency virus type 1 infection."
4.	Colonic Neoplasms (Colon Cancer) 08/01/2004 - "The purpose of this study was to determine: (1) the role of alpha5beta1 integrin expression on PI3K activity, and (2) whether blockade of alpha5beta1 integrin decreases colon cancer cell adhesion and increases apoptosis. " 03/30/1998 - "Our data suggest that de novo expression of the alpha5beta1 integrin in HT29 colon-cancer cells restores signaling via pp125FAK and pp60c-src. " 01/21/2009 - "Integrin alpha(5)beta(1) is expressed on several types of cancer cells, including colon cancer, and plays an important role in tumor growth and metastasis. " 04/20/2003 - "Targeting integrin alpha(5)beta(1) in combination with 5-FU infusion reduced liver metastases formation and improved survival in this colon cancer model. " 01/21/2009 - "The goal of this study is to design stealth liposomes (liposomes covered with polyethylene glycol (PEG)) that will target colon cancer cells that express the integrin alpha(5)beta(1). "
5.	Neoplasm Metastasis (Metastasis) 01/01/2009 - "Computer aided identification of small molecules disrupting uPAR/alpha5beta1--integrin interaction: a new paradigm for metastasis prevention." 04/20/2003 - "We hypothesized that a novel integrin alpha(5)beta(1) antagonist, ATN-161, would inhibit angiogenesis and growth of liver metastases in a murine model. " 01/27/2003 - "Here, we report the results of spontaneous metastasis tested in nude mice that were inoculated with Chinese hamster ovary (CHO) cells expressing integrin alpha 5 beta 1 at various levels. " 07/01/1998 - "Integrin alpha5beta1: a potent inhibitor of experimental lung metastasis." 05/01/1995 - "We have investigated the role of the human alpha(5) beta(1) fibronectin receptor integrin in experimental metastasis. "

Related Drugs and Biologics

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3.	Asbestos
4.	amyloid beta-protein (1-42)
5.	8-hydroxy-2'-deoxyguanosine
6.	Integrin alpha4beta1 (VLA-4)
7.	Fluorouracil (Carac)
8.	Fibronectins (Fibronectin)
9.	Integrin alphaVbeta3
10.	Integrins

Related Therapies and Procedures

1.	Therapeutics
2.	Ligation
3.	Transplants (Transplant)
4.	Heterologous Transplantation (Xenotransplantation)
5.	Autologous Transplantation