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Integrin alpha4beta1 (VLA-4)

Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
Also Known As:
VLA-4; CD49d-CD29; Integrin Heterodimer alpha4beta1; Integrin alpha(4)beta(1); Very Late Activation Antigen-4; Very Late Antigen-4; alpha4beta1 Integrin; Antigen-4, Very Late; Heterodimer alpha4beta1, Integrin; Integrin, alpha4beta1; Late Antigen-4, Very; Very Late Activation Antigen 4; Very Late Antigen 4; alpha4beta1, Integrin; alpha4beta1, Integrin Heterodimer
Networked: 564 relevant articles (34 outcomes, 66 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Anderson, Carolyn J: 11 articles (01/2022 - 05/2012)
2. Bendas, Gerd: 9 articles (02/2021 - 12/2008)
3. Hartmann, Tanja Nicole: 8 articles (04/2022 - 04/2009)
4. Schlesinger, Martin: 8 articles (02/2021 - 11/2009)
5. Storkus, Walter J: 7 articles (01/2022 - 02/2007)
6. Chigaev, Alexandre: 6 articles (01/2021 - 06/2008)
7. Lam, Kit S: 6 articles (05/2012 - 07/2006)
8. Liu, Ruiwu: 6 articles (05/2012 - 10/2004)
9. Okada, Hideho: 6 articles (10/2009 - 02/2007)
10. Gattei, Valter: 5 articles (04/2022 - 05/2015)

Related Diseases

1. Neoplasms (Cancer)
2. Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
3. Melanoma (Melanoma, Malignant)
4. Inflammation (Inflammations)
5. Multiple Sclerosis

Related Drugs and Biologics

1. Monoclonal Antibodies
2. Integrins
3. Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
4. Lymphocyte Function-Associated Antigen-1 (LFA-1)
5. Antigens
6. Cytokines
7. Natalizumab (Tysabri)
8. ammonium trichloro(dioxoethylene-O,O'-)tellurate (AS 101)
9. Tellurium
10. Ligands

Related Therapies and Procedures

1. Therapeutics
2. Ligation
3. Induction Chemotherapy
4. Drug Therapy (Chemotherapy)
5. Immunomodulation