Integrin alpha2beta1

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

Also Known As:

Networked: 155 relevant articles (0 outcomes, 19 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Eckes, Beate: 5 articles (02/2014 - 09/2006)
2.	Zutter, Mary M: 5 articles (02/2011 - 11/2003)
3.	Bouvet, Michael: 5 articles (08/2010 - 01/2005)
4.	Grzesiak, John J: 5 articles (08/2010 - 01/2005)
5.	Pozzi, Ambra: 4 articles (02/2011 - 02/2007)
6.	Eble, Johannes A: 4 articles (09/2009 - 11/2002)
7.	Krieg, Thomas: 4 articles (01/2008 - 08/2002)
8.	Zhang, Zhonghua: 3 articles (02/2011 - 02/2007)
9.	Fong, Yi-Chin: 3 articles (01/2010 - 10/2009)
10.	Tang, Chih-Hsin: 3 articles (01/2010 - 10/2009)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2009 - "In the present study, we demonstrate that expression of asialoGM1 in C4-2B cells correlates with cancer progression by influencing adhesion, migration and invasion, via reorganization of asialoGM1 and colocalization with integrin alpha2beta1. " 05/01/1991 - "Sequential immunoprecipitation studies of surface iodinated lung tumor cell lysates reveal that this heterodimeric complex is indistinguishable serologically and structurally from the integrin VLA-2, found originally on activated T lymphocytes and platelets. " 12/01/2015 - "Alpha2beta1 integrin in cancer development and chemoresistance." 10/01/2009 - "These observations reveal an uncharacterized complex of asialoGM1 with the integrin alpha2beta1 receptor promoting cancer metastatic potential through the previously identified integrin-mediated signaling pathway. " 02/15/2008 - "The alpha2beta1 integrin-dependent difference in angiogenesis was restored to LLC cells by expression of PLGF, strongly suggesting that the angiogenic phenotype and tumor growth in the alpha2-null host is dependent on specific interactions between the tumor cell and the genetically defined integrin repertoire of the host microenvironment. "
2.	Carcinoma (Carcinomatosis) 05/15/1998 - "Our previous studies demonstrated that reexpression of the alpha2beta1 integrin by a poorly differentiated breast carcinoma cell line, Mm5MT, resulted in dramatic reversion of a malignant phenotype to a differentiated epithelial phenotype. " 01/01/2007 - "Our results suggest that enhanced expression of alpha2beta1 integrin may influence spheroid disaggregation and proteolysis responsible for the peritoneal dissemination of ovarian carcinoma. " 01/01/2007 - "Alpha2beta1 integrin affects metastatic potential of ovarian carcinoma spheroids by supporting disaggregation and proteolysis." 12/01/1994 - "In differentiated carcinoma, expression of VLA-2 was weak in the mucosal layer. " 07/01/1993 - "Carcinoma cells in the intraductal components were negative for VLA-2 in only 4 (11%) of 36 cases, while 20 cases (56%) showed weak expression and 12 cases (33%) showed strong expression. "
3.	Prostatic Neoplasms (Prostate Cancer) 01/01/2010 - "In this study, we assessed the expression pattern of three surface receptors: CD133, Trop-2 and alpha2beta1 integrin in human prostate cancer in order to identify CSC-niches. " 01/01/2010 - "CD133, Trop-2 and alpha2beta1 integrin surface receptors as markers of putative human prostate cancer stem cells." 10/01/2009 - "AsialoGM1 and integrin alpha2beta1 mediate prostate cancer progression." 10/01/2009 - "In our previous studies, we reported that the invasive activity of the bone metastatic C4-2B prostate cancer cells could be ascribed to the reorganization of the alpha2beta1 integrin receptor and the alpha2 subunit-mediated association and activation of downstream signaling towards the activation of MMPs. " 01/01/2010 - "Since core3 expressing prostate cancer cells show decreased tumor formation and metastasis to lymph node through attenuating the maturation and heterodimerization of integrin alpha2beta1, those findings indicate that core3 structure acts as tumor suppressor through regulating the integrin functions. "
4.	Rhabdomyosarcoma 07/01/1996 - "Integrin VLA-2 (alpha2beta1) function in postextravasation movement of human rhabdomyosarcoma RD cells in the liver." 03/29/1991 - "In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells." 03/01/2005 - "The present study examines how an integration of the function of alpha2beta1 integrin with that of the receptor for epidermal growth factor (EGFR) modulates EGF-stimulated morphological changes in human rhabdomyosarcoma RD transfectant cells. " 03/27/1992 - "RD rhabdomyosarcoma cells expressed little VLA-2, did not bind to 35S-labeled virus, and resisted infection until transfected with complementary DNA encoding the alpha 2 subunit of VLA-2. " 07/01/1996 - "In this study, the significance of VLA-2 (alpha2beta1) integrin in the movement of human rhabdomyosarcoma RD cells in the liver was characterized by in vivo videomicroscopy. "
5.	Breast Neoplasms (Breast Cancer) 08/01/1995 - "Measurement of VLA-2 expression may thus be of clinical value as a prognostic indicator in the assessment of breast cancer." 08/01/1995 - "In human breast cancer, down-regulation of VLA-2 expression is related to positive nodal status. " 11/01/2009 - "Our studies indicate that expression of the alpha2beta1 integrin, a suppressor of metastatic breast tumor growth, is stimulated in breast tumor cells by an autocrine SEMA3A pathway." 11/01/2009 - "Based on the knowledge that both SEMA3A and the alpha2beta1 integrin suppress breast tumor cell migration, we studied the impact of SEMA3A signaling on alpha2beta1 integrin expression/function. " 08/01/1995 - "VLA-2 antibodies inhibited primary breast cancer cell attachment of women with negative nodes but not women with positive nodes. "

Related Drugs and Biologics

1.	Integrin alpha2beta1
2.	Collagen Receptors
3.	Collagen
4.	Integrin alpha6beta1
5.	Glycoproteins (Glycoprotein)
6.	Integrin alpha2
7.	Epidermal Growth Factor (EGF)
8.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
10.	Semaphorin-3A