Integrin alpha2beta1

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

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Networked: 164 relevant articles (1 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Eckes, Beate: 5 articles (02/2014 - 09/2006)
2.	Zutter, Mary M: 5 articles (02/2011 - 11/2003)
3.	Bouvet, Michael: 5 articles (08/2010 - 01/2005)
4.	Grzesiak, John J: 5 articles (08/2010 - 01/2005)
5.	Pozzi, Ambra: 4 articles (02/2011 - 02/2007)
6.	Eble, Johannes A: 4 articles (09/2009 - 11/2002)
7.	Krieg, Thomas: 4 articles (01/2008 - 08/2002)
8.	Zhang, Zhonghua: 3 articles (02/2011 - 02/2007)
9.	Fong, Yi-Chin: 3 articles (02/2010 - 10/2009)
10.	Tang, Chih-Hsin: 3 articles (02/2010 - 10/2009)

Related Diseases

1.	Disease Progression 01/01/2007 - "In contrast, VLA-4 or VLA-2 antibody treatment of mice during the priming or remission phase of EAE had minor effects on the disease's clinical course. "
2.	Neoplasms (Cancer) 10/01/2009 - "In the present study, we demonstrate that expression of asialoGM1 in C4-2B cells correlates with cancer progression by influencing adhesion, migration and invasion, via reorganization of asialoGM1 and colocalization with integrin alpha2beta1. " 12/01/2015 - "Alpha2beta1 integrin in cancer development and chemoresistance." 02/15/2008 - "alpha2beta1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell-specific manner." 01/25/2008 - "In contrast, endorepellin inhibited tumor growth and angiogenesis in the wild-type mice expressing integrin alpha2beta1. " 11/01/1997 - "In the undifferentiated type of cancers, VLA-2 negative tumors had a significantly higher incidence of vessel invasion than VLA-2 positive ones (p<0.05). "
3.	Breast Neoplasms (Breast Cancer) 05/15/1998 - "Our previous studies demonstrated that reexpression of the alpha2beta1 integrin by a poorly differentiated breast carcinoma cell line, Mm5MT, resulted in dramatic reversion of a malignant phenotype to a differentiated epithelial phenotype. " 08/01/1995 - "In human breast cancer, down-regulation of VLA-2 expression is related to positive nodal status. " 09/01/1991 - "In addition, the expression of the alpha 2 chain of VLA-2 was reduced significantly (P less than 0.005) in the poorly differentiated ductal breast carcinomas (Grade III) compared to the well (Grade I) and moderately (Grade II) differentiated ductal tumours. " 07/01/1993 - "These findings suggest that the loss of VLA-2 plays a role in the invasion and metastasis of breast carcinoma." 11/01/2009 - "Our studies indicate that expression of the alpha2beta1 integrin, a suppressor of metastatic breast tumor growth, is stimulated in breast tumor cells by an autocrine SEMA3A pathway."
4.	Prostatic Neoplasms (Prostate Cancer) 03/15/2010 - "In this study, we assessed the expression pattern of three surface receptors: CD133, Trop-2 and alpha2beta1 integrin in human prostate cancer in order to identify CSC-niches. " 03/15/2010 - "CD133, Trop-2 and alpha2beta1 integrin surface receptors as markers of putative human prostate cancer stem cells." 10/01/2009 - "AsialoGM1 and integrin alpha2beta1 mediate prostate cancer progression." 10/01/2009 - "In our previous studies, we reported that the invasive activity of the bone metastatic C4-2B prostate cancer cells could be ascribed to the reorganization of the alpha2beta1 integrin receptor and the alpha2 subunit-mediated association and activation of downstream signaling towards the activation of MMPs. " 01/01/2010 - "Since core3 expressing prostate cancer cells show decreased tumor formation and metastasis to lymph node through attenuating the maturation and heterodimerization of integrin alpha2beta1, those findings indicate that core3 structure acts as tumor suppressor through regulating the integrin functions. "
5.	Rhabdomyosarcoma 03/29/1991 - "In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells." 03/01/2005 - "The present study examines how an integration of the function of alpha2beta1 integrin with that of the receptor for epidermal growth factor (EGFR) modulates EGF-stimulated morphological changes in human rhabdomyosarcoma RD transfectant cells. " 07/01/1996 - "Integrin VLA-2 (alpha2beta1) function in postextravasation movement of human rhabdomyosarcoma RD cells in the liver." 03/27/1992 - "RD rhabdomyosarcoma cells expressed little VLA-2, did not bind to 35S-labeled virus, and resisted infection until transfected with complementary DNA encoding the alpha 2 subunit of VLA-2. " 07/01/1996 - "In this study, the significance of VLA-2 (alpha2beta1) integrin in the movement of human rhabdomyosarcoma RD cells in the liver was characterized by in vivo videomicroscopy. "

Related Drugs and Biologics

1.	Integrin alpha4beta1 (VLA-4)
2.	Integrin alpha2beta1
3.	Integrins
4.	Collagen Receptors
5.	Collagen
6.	Integrin alpha6beta1
7.	Glycoproteins (Glycoprotein)
8.	Integrin alpha2
9.	Epidermal Growth Factor (EGF)
10.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)