Hemispherectomy

A neurosurgical procedure that removes or disconnects the epileptogenic CEREBRAL CORTEX of a hemisphere. Hemispherectomy is usually performed for patients with intractable unilateral EPILEPSY due to malformations of cortical development or brain lesions. Depending on the epileptogenic area in the hemisphere, cortical removal can be total or partial.

Also Known As:

Networked: 601 relevant articles (57 outcomes, 58 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Mathern, Gary W: 17 articles (01/2023 - 02/2004)
2.	Bingaman, William: 10 articles (01/2024 - 02/2009)
3.	Wyllie, Elaine: 10 articles (01/2022 - 01/2002)
4.	Gupta, Ajay: 9 articles (01/2022 - 09/2005)
5.	Ochi, Ayako: 8 articles (10/2023 - 12/2010)
6.	Chugani, Harry T: 8 articles (10/2020 - 07/2006)
7.	Otsubo, Hiroshi: 7 articles (10/2023 - 12/2006)
8.	Fallah, Aria: 6 articles (11/2023 - 12/2011)
9.	Ibrahim, George M: 6 articles (10/2023 - 12/2011)
10.	Luan, Guoming: 6 articles (08/2022 - 01/2014)

Related Diseases

1.	Seizures (Absence Seizure) 11/01/1989 - "Hemispherectomy was performed in two children with sudden and complete recovery from seizures and improvement in psychomotor development. " 08/01/1999 - "Hemispherectomy procedures are performed in patients for whom focal cortical resection would be predicted to produce a significant reduction in seizures. " 12/01/2000 - "In this study, we investigated 17 patients who had undergone hemispherectomy for relief from seizures; eight of the patients had congenital brain damage and nine had sustained their initial insult at the age of 1 year or older. " 07/01/2016 - "The only effective treatment for refractory seizures in childhood is hemispherectomy. " 04/01/2010 - "Hemispherectomy is currently the only effective treatment for relieving constant seizures in children with severe or progressive unilateral cortical disease. "
2.	Drug Resistant Epilepsy 10/01/2023 - "Hemispherectomy is highly effective for patients with medically refractory epilepsy (MRE) arising from a single hemisphere. " 01/01/2015 - "Hemispherectomy is highly effective for treating refractory epilepsy in the pediatric age group, particularly for acquired and progressive etiologies. " 06/01/2014 - "We present a case of a young boy with a large hemispheric dysplasia, generalized EEG abnormalities and intractable epilepsy who achieved seizure freedom and markedly improved cognitive outcome after functional hemispherectomy. " 01/01/2022 - "Functional hemispherectomy results in good outcomes in cases of refractory epilepsy and constitutes a unique situation in which to study cerebral plasticity and the reorganization of lateralized functions of the brain, especially in cases of infancy or childhood surgery. " 01/01/1995 - "Hemispherectomy is well recognized as an effective treatment for some types of intractable epilepsy, but the procedure is also known to be associated with significant late complications. "
3.	Epilepsy (Aura) 01/01/2018 - "Sixty years after the disease was first described, the preferred and best treatment option for RE is grotesque and involves removing a hemisphere of the brain (hemispherectomy); therefore, a better understanding of this seizure disorder may provide additional, less invasive therapeutic options. " 01/30/2024 - "Resective epilepsy surgery can have a very good outcome, also in patients with genetic mutations in COL4A1, constituting a less invasive option than the previously used more radical surgical procedures such as hemispherectomy." 01/01/2016 - "For patients with intractable pediatric epilepsy, the role of intracranial electrodes, resective surgery, hemispherectomy, corpus callosotomy, neurostimulation, and multiple subpial transections continues to be very effective in select cases. " 01/01/2023 - "Hemispherectomy as a repeat surgery after unsuccessful subhemispheric epilepsy surgery has a favorable seizure outcome, with stable or improved intelligence and adaptive functioning. " 12/01/2010 - "After subsequent surgeries for seizure control, 4 HD patients and 1 PIH patient improved to Engel class I or II. Hemispherectomy is an effective surgical procedure for childhood intractable catastrophic epilepsy. "
4.	Hemimegalencephaly 04/01/1991 - "Hemimegalencephaly (HME) is a severe unilateral brain malformation the prognosis of which may be improved by hemispherectomy. " 12/01/2021 - "Functional cognitive and language outcomes after cerebral hemispherectomy for hemimegalencephaly." 01/01/2020 - "Minimizing blood loss in hemispherectomy for hemimegalencephaly in low-weight infants: technical note." 01/01/2018 - "Hemimegalencephaly: Seizure Outcome in an Infant after Hemispherectomy." 11/01/2004 - "Diffusion property following functional hemispherectomy in hemimegalencephaly."
5.	Encephalitis (Encephalitis, Rasmussen) 09/01/2011 - "[Three children with Rasmussen encephalitis showing marked improvement in daily life activity following the functional hemispherectomy]." 01/01/2022 - "The objectives of this study were to determine the relationship between the severity of pathology and seizure outcomes in patients who underwent hemispherectomy for Rasmussen encephalitis (RE) and to investigate which clinical factors correlated with severity of pathology. " 03/01/2006 - "To test more directly whether RIFG activation shifts in a potentially adaptive manner after left hemisphere injury, fMRI studies were performed in a patient prior to and following anatomical left hemispherectomy for the treatment of Rasmussen's encephalitis. " 05/16/2024 - "Insights on cognitive reorganization after hemispherectomy in Rasmussen's encephalitis. " 04/26/2024 - "In cases refractory to immunotherapy, interventions used in refractory Rasmussen's encephalitis may be considered, such as functional hemispherectomy."

Related Drugs and Biologics

1.	Valproic Acid (Depakote)
2.	Phenytoin (Dilantin)
3.	Phenobarbital (Luminal)
4.	Carbamazepine (Tegretol)
5.	Levetiracetam (Keppra)
6.	Topiramate (Topamax)
7.	Lamotrigine (Lamictal)
8.	Gabapentin (Neurontin)
9.	Steroids
10.	Vigabatrin

Related Therapies and Procedures

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2.	Operative Surgical Procedures
3.	Transcranial Magnetic Stimulation
4.	Electrodes (Electrode)
5.	Vagus Nerve Stimulation