Glycogen Synthase Kinases

A class of protein-serine-threonine kinases that was originally found as one of the three types of kinases that phosphorylate GLYCOGEN SYNTHASE. Glycogen synthase kinases along with CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASES and CYCLIC AMP-DEPENDENT PROTEIN KINASES regulate glycogen synthase activity.

Also Known As:

Networked: 841 relevant articles (18 outcomes, 80 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Minamoto, Toshinari: 15 articles (12/2020 - 01/2006)
2.	Gong, Rujun: 10 articles (01/2021 - 04/2012)
3.	Nakada, Mitsutoshi: 8 articles (01/2020 - 02/2009)
4.	Domoto, Takahiro: 7 articles (12/2020 - 02/2015)
5.	Ge, Yan: 6 articles (01/2020 - 04/2012)
6.	Chen, Chia-Ling: 6 articles (01/2018 - 09/2009)
7.	Lin, Chiou-Feng: 6 articles (03/2016 - 09/2009)
8.	Kawakami, Kazuyuki: 6 articles (10/2013 - 01/2006)
9.	Billadeau, Daniel D: 5 articles (01/2020 - 02/2006)
10.	Miyashita, Katsuyoshi: 5 articles (04/2017 - 01/2006)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "In this study, with both human cancer cell lines and normal fibroblasts, we found glycogen synthase kinase 3β (GSK-3β) regulates DHX33 protein stability. " 12/02/2021 - "Glycogen synthase kinase 3β (GSK-3β) is an emerging target in human malignancies. " 02/01/2020 - "An emerging target is glycogen synthase kinase (GSK)3β, which is implicated in various diseases including cancer. " 01/01/2020 - "Glycogen synthase kinase (GSK)3β has emerged as a multipotent therapeutic target in various diseases including cancer. " 01/01/2020 - "Glycogen Synthase Kinase 3β in Cancer Biology and Treatment."
2.	Reperfusion Injury 01/01/2018 - "Therefore, therapeutic targeting of glycogen synthase kinase 3β enhances innate immune regulation and protects liver from ischaemia and reperfusion injury." 10/24/2008 - "Inhibition of glycogen synthase kinase (GSK)-3 reduces ischemia/reperfusion injury by mechanisms that involve the mitochondria. " 05/01/2006 - "Inhibition of glycogen synthase kinase (GSK)-beta protects against ischemia-reperfusion injury. " 03/01/2019 - "Glycogen synthase kinase 3β (GSK-3β) emerged as an important risk factor for brain ischemia reperfusion injury, and GSK-3β inhibits autophagic activity in many diseases. " 11/01/2015 - "Diverse transmitting pathways trigger a variety of signaling cascades, including the reperfusion injury salvage kinase and survivor activating factor enhancement pathways, all of which converge on glycogen synthase kinase 3β (GSK3β). "
3.	Alzheimer Disease (Alzheimer's Disease) 09/01/2023 - "Glycogen synthase kinase 3β (GSK-3β) is a potential target for anti-Alzheimer's disease (AD) drug development. " 08/22/2023 - "It has been proposed that glycogen synthase kinase 3β (GSK3β) is involved in the hyperphosphorylation of tau in Alzheimer's disease. " 11/21/2021 - "Among the previously examined potential molecular players in IBM is glycogen synthase kinase (GSK)-3, whose role in promoting TAU phosphorylation and inclusion bodies in Alzheimer's disease is well known. " 10/19/2021 - "Correction for Sen et al., Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3β in Alzheimer's disease." 04/15/2020 - "Furthermore, CBD prevents the glycogen synthase kinase 3β (GSK-3β) hyperphosphorylation caused by Aβ and may be developed as a new therapeutic candidate for Alzheimer's disease."
4.	Insulin Resistance 01/01/2019 - "Spleen-kidney supplementing formula alleviates insulin resistance via regulating AKT/glycogen synthase kinase 3β pathway in rats with type 2 diabetic induced by high-fat diet." 01/01/2019 - "Common features such as central insulin resistance, altered glycogen synthase kinase 3β (GSK3β) signalling, and central inflammation are discussed, and therapeutic interventions targeting those mechanisms are mentioned briefly." 09/01/2015 - "It was also proposed that hyper insulinemia induced insulin resistance results in injury to the central nervous system by the activation of glycogen synthase kinase 3β which is the key ailment in the cognitive decline. " 01/01/2017 - "Here, we found that over-expression of CtBP2 ameliorated insulin sensitivity by increasing phosphorylation of glycogen synthase kinase 3β (GSK3β) and protein kinase B (AKT). " 04/01/2008 - "Rapamycin decreased muscle insulin sensitivity paralleled by increased glycogen synthase kinase 3beta activity. "
5.	Myocardial Infarction 01/01/2019 - "Letter to the editor regarding article, "Role of glycogen synthase kinase following myocardial infarction and ischemia-reperfusion"." 01/01/2019 - "Role of glycogen synthase kinase following myocardial infarction and ischemia-reperfusion." 01/01/2017 - "Role of glycogen synthase kinase following myocardial infarction and ischemia-reperfusion." 12/01/2008 - "We investigated the role of the Akt-glycogen synthase kinase (GSK)-3beta signalling pathway in mediating the protective effects of tissue kallikrein on myocardial injury by promoting angiogenesis and blood flow in rats after myocardial infarction (MI). " 05/01/2006 - "Inhibition of glycogen synthase kinase enhances isoflurane-induced protection against myocardial infarction during early reperfusion in vivo."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Catenins
3.	beta Catenin
4.	Proto-Oncogene Proteins c-akt (Protein Kinase B)
5.	Phosphotransferases (Kinase)
6.	Phosphatidylinositols (Phosphatidylinositol)
7.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
8.	AMP-Activated Protein Kinases
9.	Isoflurane
10.	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Precision Medicine
4.	Resistance Training
5.	Neoadjuvant Therapy