Sirtuins

A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.

Also Known As:

Networked: 2289 relevant articles (137 outcomes, 310 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mai, Antonello: 20 articles (04/2022 - 09/2009)
2.	Ahmad, Nihal: 15 articles (01/2021 - 02/2009)
3.	Mostoslavsky, Raul: 15 articles (01/2020 - 05/2008)
4.	Ricke, Jens: 13 articles (09/2022 - 10/2009)
5.	Sangro, Bruno: 13 articles (09/2022 - 01/2012)
6.	Rolland, Yan: 13 articles (06/2022 - 11/2015)
7.	Rotili, Dante: 13 articles (04/2022 - 02/2010)
8.	Lin, Hening: 13 articles (01/2021 - 08/2012)
9.	Jung, Manfred: 12 articles (01/2022 - 01/2008)
10.	Sippl, Wolfgang: 12 articles (01/2022 - 01/2008)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2016 - "SIRT inhibition may be beneficial in decreasing the risk of some cancers, while SIRT activation can exert positive antiaging effects and help prevent age-related disease and cancers. " 06/01/2023 - "Cotreatment with Sirt and Mont proved more effective anti-tumor activity in TNBC cell line and in SEC bearing mice than either treatment alone, which could be attributed to the inhibition of sirtuin-1 and AKT- activated pathways, with the subsequent inhibition of EMT." 02/01/2011 - "Consequently, interventions predicated on disrupting the interactions between tumour suppressors and SIRTs may be effective in circumventing or reversing drug resistance in cancer." 07/01/2009 - "Numerous studies have evaluated the safety and efficacy of SIRT, and it has been used to treat both primary and metastatic hepatic malignancies. " 01/10/2021 - "Extensive research on the expression of SIRTs in various pathological conditions suggests that regulation of their activity may have positive results in supporting the treatment of certain metabolic, neurodegenerative or cancer diseases or this connected with oxidative stress. "
2.	Neoplasm Metastasis (Metastasis) 05/01/2001 - "SIRT is a highly effective and well-tolerated regional treatment for extensive colorectal liver metastases. " 01/01/2017 - "Median OS from first Y-SIRT was significantly greater in the absence of diffuse (>10) liver metastases (15.1 vs. 4.7 mo, P=0.02), and in the absence of extrahepatic metastases (21.3 vs. 8.6 mo, P<0.001). " 01/01/2022 - "SIRT appears to be a safe treatment for patients with unresectable hepatic metastases from UM. " 01/01/2022 - "SIRT appears to be a safe and effective treatment for patients with unresectable hepatic metastases from UM. " 07/20/2022 - "This trial will provide prospective evidence on the efficacy of SIRT using TheraSpheres for the management of liver metastases. "
3.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2013 - "These results may help develop a novel treatment option for colorectal cancer using a SIRT inhibitor. " 08/01/2020 - "TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents." 01/01/2023 - "The current research aims to understand the role of sirtuin 6 (SIRT6) in CRC-associated NK cell exhaustion in a murine inflammatory colorectal cancer model. " 03/16/2022 - "Growing evidence shows that SIRTs have pivotal roles in chronic degenerative diseases, including colorectal cancer (CRC), the third most frequent malignant disease worldwide. " 03/16/2022 - "Mitochondrial Sirtuins in Chronic Degenerative Diseases: New Metabolic Targets in Colorectal Cancer."
4.	Inflammation (Inflammations) 09/01/2022 - "Our previous study showed that Sirtuin 6 (Sirt6) plays an important role in the regulation of vascular endothelial cell inflammation. " 11/30/2012 - "Studies show that the sirtuin SIRT6 promotes inflammation by enhancing TNF expression. " 01/01/2011 - "In this study, we investigated the expression and localization of endogenous sirtuins in primary human dermal microvascular endothelial cells (HDMEC), a cell type playing a key role in the development and maintenance of skin inflammation. " 03/01/2010 - "Our study identifies redundant, but essential, roles for class I/II and sirtuin HDACs in promoting inflammation, angiogenesis, and cell survival in RA." 11/10/2023 - "Also, we discuss available data pointing to the dual role that, in particular contexts, sirtuins may have on inflammation control. "
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2020 - "This article summarizes the associations of sirtuins with the mtUPR as well as specific molecular targets related to the mtUPR in different disease models, which will provide new inspiration for studies on mitochondrial stress, mitochondrial function protection, and mitochondria-related diseases, such as neurodegenerative diseases." 10/01/2013 - "Lastly, we highlight the numerous studies suggesting that sirtuins are efficacious therapeutic targets in neurodegenerative disease and injury." 12/01/2023 - "In this review, we have presented an updated Sirtuins and its role in ageing and age-related neurodegenerative diseases (NDDs). " 12/01/2023 - "Sirtuins, a key regulator of ageing and age-related neurodegenerative diseases." 06/01/2023 - "In addition, we outline the potential therapeutic applications for neurodegenerative diseases of targeting sirtuin-mediated mitochondrial quality control through exercise training, calorie restriction, and sirtuin modulators in neurodegenerative diseases."

Related Drugs and Biologics

1.	Sirtuins
2.	Sirtuin 1
3.	Proteins (Proteins, Gene)
4.	NAD (NADH)
5.	Yttrium-90
6.	Histone Deacetylases (Histone Deacetylase)
7.	Resveratrol
8.	Glucose (Dextrose)
9.	Sirtuin 3
10.	Lipids

Related Therapies and Procedures

1.	Radiotherapy
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)
4.	Microspheres (Microsphere)
5.	Caloric Restriction