Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)

An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens and enhances their opsinization and killing by phagocytic cells. Surfactant protein D contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.

Also Known As:

Networked: 598 relevant articles (42 outcomes, 110 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Holmskov, Uffe: 30 articles (12/2015 - 09/2002)
2.	Crouch, Erika C: 24 articles (11/2013 - 06/2002)
3.	Beers, Michael F: 21 articles (07/2015 - 01/2003)
4.	Hawgood, Samuel: 19 articles (01/2016 - 03/2002)
5.	Madan, Taruna: 17 articles (02/2016 - 09/2002)
6.	Kishore, Uday: 16 articles (02/2016 - 05/2003)
7.	Hartshorn, Kevan L: 16 articles (11/2013 - 06/2002)
8.	Gow, Andrew J: 14 articles (07/2015 - 03/2004)
9.	Atochina-Vasserman, Elena N: 13 articles (07/2015 - 10/2005)
10.	Whitsett, Jeffrey A: 13 articles (07/2010 - 06/2002)

Related Diseases

1.	Infection 01/01/2005 - "Our data provides evidence that SP-D has a significant role to play in the clearance of pneumococci during the early stages of infection in both pulmonary sites and blood." 07/01/2000 - "The in vivo significance is unclear but the enhanced binding of spores may increase the chance of fungal infection in the lung which could be prevented by the protective effects of lung surfactant components (possibly SP-D). " 06/01/2009 - "Here we developed a novel null-infection model to test the hypothesis that SP-D contributes to the clearance of viable Pseudomonas aeruginosa from the healthy ocular surface in vivo. " 06/01/2009 - "Pulmonary SP-D is a defence lectin promoting clearance of viral infections. " 03/01/2003 - "SP-A and SP-D coordinate the innate and adaptive immune response in the lung and convey protection against infection in amniotic fluid and vernix caseosa. "
2.	Inflammation 07/01/2001 - "These data suggest that clearance of SP-D into lung tissue is increased during inflammation and that tissue-associated neutrophils significantly contribute to this process." 12/01/2015 - "Protective effects of surfactant protein D treatment in 1,3-β-glucan-modulated allergic inflammation." 07/01/2001 - "Enhanced clearance of surfactant protein D during LPS-induced acute inflammation in rat lung." 02/01/2001 - "SP-D(-/-) mice cleared these bacteria as efficiently as wild-type mice; however, clearance of viral pathogens was deficient in SP-D(-/-) mice and associated with increased inflammation. " 06/01/2013 - "The study also confirms the concept of using increased SP-D serum levels as a biomarker of especially chronic airway inflammation."
3.	Hypersensitivity (Allergy) 12/21/2007 - "A recombinant fragment of SP-D that is effective in diminishing allergic hypersensitivity in mouse models of dust mite allergy was more susceptible to degradation than the native full-length protein. " 05/01/2008 - "We aimed to determine the effect of SP-D deficiency on murine and human airway allergy. " 12/01/2006 - "Various murine models of pulmonary hypersensitivity suggest that SP-D may be a potent anti-allergic protein. " 02/01/2001 - "These results clearly implicate pulmonary SP-A and SP-D in the modulation of allergic reactions." 11/01/1996 - "It is therefore possible that SP-A and SP-D may be involved in the modulation of allergen sensitization and/or the development of allergic reactions."
4.	Pneumonia (Pneumonitis) 10/01/2013 - "To study the alterations and relationship of surfactant protein (SP)-A, SP-D and KL-6 in serum and bronchoalveolar lavage fluids (BALF) in children with Mycoplasma pneumoniae pneumonia (MPP). " 12/01/2015 - "We set out to investigate if SP-D could interact with 1,3-β-glucan and attenuate allergic pulmonary inflammation in the presence of 1,3-β-glucan. " 07/01/2015 - "Consistent with the growth of TSC2-null lesions, NO levels were also increased and, in turn, modified SP-D through S-nitrosylation, forming S-nitrosylated SP-D, a known consequence of lung inflammation. " 01/01/2015 - "SP-D, KL-6, and HTI-56 levels in children with mycoplasma pneumoniae pneumonia." 03/01/2014 - "T/HS decreased lung SP-D by 1.8-fold (p < 0.05), increased PA bacterial burden 9-fold (p < 0.05), and increased PA pneumonia mortality by 80% (p < 0.001). "
5.	Lung Injury 04/01/2012 - "Furthermore, the current results show that there is a significant reduction in the activity of iNOS in lung tissue and increased serum SP-D levels of AC and PEG aspiration-induced lung injury with INF treatment. " 06/01/2013 - "The aim of current study was to characterize comparatively the SP-D response in bronchoalveolar lavage (BAL) and serum in three murine models of lung injury, using a validated ELISA technology for estimation of SP-D levels. " 11/11/2015 - "A low-phosphate diet prevents microlith formation in young animals and reduces lung injury on the basis of reduction in serum SP-D. " 03/01/2015 - "Herein, we analyzed the role of iNOS and SP-D in radiation-induced lung injury. " 01/01/2012 - "Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury."

Related Drugs and Biologics

1.	Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)
2.	Proteins (Proteins, Gene)
3.	Collectins (Collectin)
4.	Allergens
5.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
6.	Biological Markers (Surrogate Marker)
7.	C-Reactive Protein
8.	Immunoglobulin E (IgE)
9.	Pancreatic Elastase (Elastase)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Intranasal Administration
2.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
3.	Chemoprevention
4.	Cyclotrons
5.	Homologous Transplantation (Allograft)