Pulmonary Surfactant-Associated Protein A (Surfactant Protein A)

An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.

Also Known As:

Networked: 386 relevant articles (7 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Floros, Joanna: 16 articles (01/2022 - 01/2002)
2.	Phelps, David S: 12 articles (01/2022 - 01/2002)
3.	Wang, Guirong: 12 articles (10/2019 - 01/2002)
4.	Ledford, Julie G: 9 articles (01/2020 - 06/2010)
5.	Takahashi, Hiroki: 8 articles (01/2020 - 07/2003)
6.	Umstead, Todd M: 8 articles (01/2019 - 01/2002)
7.	Wright, Jo Rae: 8 articles (07/2012 - 01/2003)
8.	Alcorn, Joseph L: 5 articles (01/2022 - 12/2005)
9.	Chiba, Hirofumi: 5 articles (01/2020 - 05/2004)
10.	Kraft, Monica: 5 articles (01/2020 - 10/2010)

Related Diseases

1.	Infections 12/01/2022 - "Furthermore, infected cells with frosted nuclei were positive for surfactant protein A (SP-A) in Case 2, suggesting infection of type II alveolar pneumocytes or Clara cells. " 01/01/2022 - "Surfactant Protein A, which we observed to be significantly reduced by LPS, may be associated with the regulation of the epithelial response, especially during preterm delivery due to infection. " 01/01/2022 - "Comparison of the Toponomes of Alveolar Macrophages From Wild Type and Surfactant Protein A Knockout Mice and Their Response to Infection." 04/16/2020 - "Staphylococcus aureus Lung Infection Results in Down-Regulation of Surfactant Protein-A Mainly Caused by Pro-Inflammatory Macrophages." 12/06/2019 - "Surfactant Protein A Impairs Genital HPV16 Pseudovirus Infection by Innate Immune Cell Activation in A Murine Model."
2.	Lung Injury 09/15/2014 - "Pretreatment with KGF-2 improved the above lung injury parameters, partially restored surfactant protein A and C expression, and KGF-2 given 2-3 days before LPS challenge showed maximum lung injury improvement. " 08/01/2001 - "Surfactant protein A may be an important modulator of the immune response to lung injury. " 09/01/2002 - "Surfactant protein A decreases lung injury and mortality after murine marrow transplantation." 05/01/2008 - "Circulating surfactant protein A (SP-A), a marker of lung injury, is associated with insulin resistance." 11/01/1992 - "Surfactant protein A (SP-A) is decreased in acute parenchymal lung injury associated with polytrauma."
3.	Allergic Rhinitis 04/01/2013 - "Protective effects of exogenous surfactant protein A in allergic rhinitis: a mouse model." 04/01/2013 - "A mouse model of allergic rhinitis (AR) was prepared, and exogenous surfactant protein A (SP-A) was given by an intranasal route to study its mechanism and effects in the mice. " 03/01/2011 - "Relationship between surfactant protein A polymorphisms and allergic rhinitis in a Chinese Han population." 09/01/2006 - "To characterize surfactant protein A (SP-A) expression in human nasal tissue and correlate differential expression of SP-A with symptoms suggestive of allergic rhinitis. "
4.	Acute Lung Injury 01/01/2014 - "Surfactant protein A (SP-A) contributes to the regulation of sepsis-induced acute lung injury. " 07/01/2008 - "To investigate the expression and function of surfactant protein A (SP-A) in lung in rats with acute lung injury (ALI) induced by severe acute pancreatitis (SAP). " 06/15/2010 - "The role of surfactant protein A in bleomycin-induced acute lung injury." 04/01/2011 - "To investigate the effect of hypothermia (HT) on the concentration of surfactant protein A (SP-A) during lipopolysaccharide (LPS) induced acute lung injury (ALI) in rats. " 04/01/2011 - "[Effects of hypothermia on the concentration of surfactant protein A during endotoxin induced acute lung injury in rats]."
5.	Ischemia 06/21/2005 - "Declining levels of surfactant protein A (SP-A) after lung transplantation are suggested to indicate progression of ischemia/reperfusion (IR) injury. " 08/01/2007 - "Because surfactant protein A reduces the sensitivity to inhibition of the biophysical activity of surfactant by exudating plasma proteins, we propose that pretreatment of lungs with DeltaN23-KGF ameliorates adverse effects observed in acute lung injury following, for example, ischemia and reperfusion." 08/01/1997 - "If untreated, the reimplantation response had almost resolved in the 6-h but not in the 20-h ischemia group; pulmonary surfactant, however, continued to be deficient in both ischemia groups (low amounts of surfactant phospholipids and surfactant protein A [SP-A]). "

Related Drugs and Biologics

1.	Surface-Active Agents (Surfactants)
2.	Chemokines
3.	Interleukins
4.	Cytokines
5.	Oxygen (Dioxygen)
6.	disaturated lecithins
7.	Nitrogen
8.	Blood Proteins (Serum Proteins)
9.	Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)
10.	IgA receptor (protein B)

Related Therapies and Procedures

1.	Therapeutics
2.	Extracorporeal Membrane Oxygenation
3.	Microbubbles
4.	Drug Therapy (Chemotherapy)
5.	Cardiopulmonary Bypass (Heart-Lung Bypass)