Pulmonary Surfactant-Associated Protein A (Surfactant Protein A)

An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.

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Networked: 265 relevant articles (7 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Floros, Joanna: 10 articles (05/2015 - 01/2002)
2.	Wang, Guirong: 10 articles (10/2014 - 01/2002)
3.	Phelps, David S: 8 articles (10/2014 - 01/2002)
4.	Wright, Jo Rae: 8 articles (07/2012 - 01/2003)
5.	Umstead, Todd M: 7 articles (10/2014 - 01/2002)
6.	Ledford, Julie G: 5 articles (05/2013 - 06/2010)
7.	McCormack, Francis X: 4 articles (05/2015 - 02/2002)
8.	Guzman, Josune: 4 articles (01/2014 - 03/2005)
9.	Costabel, Ulrich: 4 articles (01/2014 - 03/2005)
10.	Mukherjee, Sambuddho: 4 articles (05/2012 - 06/2010)

Related Diseases

1.	Infection 07/01/2012 - "We previously reported that mice lacking surfactant protein A (SP-A) have increased airway hyperresponsiveness (AHR) during M pneumoniae infection versus wild-type mice mediated by TNF-α. " 05/04/2012 - "[Recombinant porcine lung surfactant protein A inhibits porcine reproductive and respiratory syndrome virus infection into host cells in vitro]." 01/01/2011 - "Mice lacking surfactant protein-A (SP-A-/-; knockout; KO) exhibit increased vulnerability to infection and injury. " 10/01/2009 - "Therefore, the decrease in SP-A protein levels observed after RSV infection of pulmonary bronchiolar epithelial cells results from a mechanism that affects SP-A mRNA translation efficiency." 10/01/2009 - "Respiratory syncytial virus infection alters surfactant protein A expression in human pulmonary epithelial cells by reducing translation efficiency."
2.	Lung Injury 09/15/2014 - "Pretreatment with KGF-2 improved the above lung injury parameters, partially restored surfactant protein A and C expression, and KGF-2 given 2-3 days before LPS challenge showed maximum lung injury improvement. " 08/01/2001 - "Surfactant protein A may be an important modulator of the immune response to lung injury. " 11/01/1992 - "Surfactant protein A (SP-A) is decreased in acute parenchymal lung injury associated with polytrauma." 09/01/2002 - "Surfactant protein A decreases lung injury and mortality after murine marrow transplantation." 05/01/2008 - "Circulating surfactant protein A (SP-A), a marker of lung injury, is associated with insulin resistance."
3.	Rhinitis 04/01/2013 - "Protective effects of exogenous surfactant protein A in allergic rhinitis: a mouse model." 04/01/2013 - "A mouse model of allergic rhinitis (AR) was prepared, and exogenous surfactant protein A (SP-A) was given by an intranasal route to study its mechanism and effects in the mice. " 03/01/2011 - "Relationship between surfactant protein A polymorphisms and allergic rhinitis in a Chinese Han population." 09/01/2006 - "To characterize surfactant protein A (SP-A) expression in human nasal tissue and correlate differential expression of SP-A with symptoms suggestive of allergic rhinitis. "
4.	Acute Lung Injury 09/15/2014 - "Lipopolysaccharide instillation caused acute lung injury, which significantly elevated lung wet-to-dry weight ratio, protein and neutrophils in bronchoalveolar lavage fluid (BALF), inhibited surfactant protein A and C expression in lung tissue, and increased pathological injury. " 01/01/2014 - "Surfactant protein A (SP-A) contributes to the regulation of sepsis-induced acute lung injury. " 04/01/2011 - "To investigate the effect of hypothermia (HT) on the concentration of surfactant protein A (SP-A) during lipopolysaccharide (LPS) induced acute lung injury (ALI) in rats. " 04/01/2011 - "[Effects of hypothermia on the concentration of surfactant protein A during endotoxin induced acute lung injury in rats]." 07/01/2008 - "To investigate the expression and function of surfactant protein A (SP-A) in lung in rats with acute lung injury (ALI) induced by severe acute pancreatitis (SAP). "
5.	Ischemia 01/01/2005 - "Declining levels of surfactant protein A (SP-A) after lung transplantation are suggested to indicate progression of ischemia/reperfusion (IR) injury. " 08/01/2007 - "Because surfactant protein A reduces the sensitivity to inhibition of the biophysical activity of surfactant by exudating plasma proteins, we propose that pretreatment of lungs with DeltaN23-KGF ameliorates adverse effects observed in acute lung injury following, for example, ischemia and reperfusion." 08/01/1997 - "If untreated, the reimplantation response had almost resolved in the 6-h but not in the 20-h ischemia group; pulmonary surfactant, however, continued to be deficient in both ischemia groups (low amounts of surfactant phospholipids and surfactant protein A [SP-A]). "

Related Drugs and Biologics

1.	Oxygen
2.	disaturated lecithins
3.	Nitrogen
4.	Interleukins
5.	Blood Proteins (Serum Proteins)
6.	Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)
7.	IgA receptor (protein B)
8.	Phospholipids
9.	Phosphatidylcholines (Phosphatidylcholine)
10.	Antibodies

Related Therapies and Procedures

1.	Extracorporeal Membrane Oxygenation (ECMO)
2.	Cardiopulmonary Bypass (Heart-Lung Bypass)
3.	Lung Transplantation
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
5.	Transplantation (Transplant Recipients)