A group of SESQUITERPENES and their analogs that contain a peroxide group (PEROXIDES) within an oxepin ring (OXEPINS).
Networked: 126 relevant articles (12 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Haynes, Richard K: 18 articles (11/2015 - 11/2004)
2. Efferth, Thomas: 8 articles (10/2015 - 07/2004)
3. Krishna, Sanjeev: 7 articles (08/2013 - 11/2004)
4. Monti, Diego: 7 articles (08/2013 - 10/2007)
5. Coghi, Paolo: 6 articles (08/2013 - 12/2009)
6. Taramelli, Donatella: 5 articles (12/2014 - 10/2007)
7. Keiser, Jennifer: 5 articles (12/2014 - 02/2007)
8. White, Nicholas J: 5 articles (03/2013 - 04/2004)
9. Utzinger, Jürg: 5 articles (01/2010 - 07/2006)
10. Cheu, Kwan-Wing: 4 articles (08/2013 - 02/2011)

Related Diseases

1. Malaria
2. Schistosomiasis (Bilharziasis)
02/01/2007 - "Artemisinins for schistosomiasis and beyond."
07/01/2006 - "Since the artemisinins also exhibit antischistosomal properties, their use in areas where malaria and schistosomiasis are co-endemic may have an effect on both diseases and co-infection might alter drug efficacy. "
11/01/2013 - "According to the experimental studies, the deepest impression on the antischistosomal properties of mefloquine can be summarized as following points: (1) single dose of mefloquine possesses potential effect against three major species of schistosomes (Schistosoma mansoni, Schistosoma haematobium, and Schistosoma japonicum) infecting humans; (2) the drug displays similar effects against developing stages of juvenile and adult schistosomes, which are superior to that of artemisinins and praziquantel; (3) in vitro mefloquine exerts direct killing effect on juvenile and adult schistosomes, while in vivo, the efficacy of the drug is independent to host immune response, (4) mefloquine causes extensive and severe morphological, histopathological, and ultrastructural damage to adult and juvenile schistosomes, particularly, the worm tegument, musculature, gut, and vitelline glands of female worms are the key sites attacked by the drug; (5) combined treatment with mefloquine and praziquantel, or artemisinins shows synergistic effect against schistosome in experimental therapy,while in initially clinical trial, mefloquine in combination with artesunate also exhibits higher cure rates against schistosomiasis hematobia and schistosomiasis mansoni, and (6) several mefloquine-related arylmethanols exhibit potential effect against schistosomes in vivo, which is a useful clue helpful for development of new antischistosomal compound. "
12/01/2014 - "The most clinically advanced drug candidates include the artemisinins and mefloquine against schistosomiasis, tribendimidine against liver flukes, oxantel pamoate against trichuriasis, and doxycycline against filariasis. "
3. Schistosomiasis mansoni
4. Falciparum Malaria (Plasmodium falciparum Malaria)
5. Vivax Malaria

Related Drugs and Biologics

1. artesunate
2. Antimalarials (Antimalarial Agents)
3. artemisinine (artemisinin)
4. Chloroquine (Aralen)
5. artemether
6. Mefloquine (Lariam)
7. Praziquantel (Biltricide)
8. tribendimidine
9. Tetraoxanes
10. Primaquine

Related Therapies and Procedures

1. Investigational Therapies (Experimental Therapy)
2. Drug Therapy (Chemotherapy)
3. Intramuscular Injections
4. Injections
5. Aftercare (After-Treatment)