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Galectin 3 (LGALS3)

A multifunctional galactin initially discovered as a macrophage antigen that binds to IMMUNOGLOBULIN E, and as 29-35-kDa lectin that binds LAMININ. It is involved in a variety of biological events including interactions with galactose-containing glycoconjugates, cell proliferation, CELL DIFFERENTIATION, and APOPTOSIS.

Also Known As:

LGALS3; CBP-30; CBP-35; CBP35; Carbohydrate-Binding Protein 35; Epsilon-Binding Protein; Galectin-3; HL-29; IgE Binding Protein; IgEBP; L-29 Lectin; L-31; L-34; L30 Lectin; Macrophage-2 Antigen; Antigen, Mac-2; Antigen, Macrophage-2; Binding Protein, IgE; Carbohydrate Binding Protein 35; Epsilon Binding Protein; L 29 Lectin; Mac 2 Antigen; Macrophage 2 Antigen; Protein, IgE Binding; Mac-2 Antigen

Networked: 1323 relevant articles (46 outcomes, 286 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Lectins: 1537
    - Galectins: 543
      - Galectin 3: 1323
        mouse Lgals3 protein

Experts

1.	Liu, Fu-Tong: 55 articles (02/2016 - 02/2002)
2.	Raz, Avraham: 50 articles (08/2015 - 03/2002)
3.	Gabius, Hans-Joachim: 32 articles (07/2015 - 01/2002)
4.	Hsu, Daniel K: 27 articles (10/2013 - 03/2002)
5.	Chammas, Roger: 25 articles (08/2015 - 10/2004)
6.	de Boer, Rudolf A: 22 articles (01/2016 - 09/2009)
7.	André, Sabine: 20 articles (07/2015 - 01/2002)
8.	Nangia-Makker, Pratima: 18 articles (10/2014 - 12/2002)
9.	van Veldhuisen, Dirk J: 13 articles (01/2016 - 09/2009)
10.	Januzzi, James L: 13 articles (06/2015 - 09/2006)

Related Diseases

1.	Neoplasms (Cancer) 03/30/2012 - "Most human tumors are not eliminated by the immune system, and therapeutic vaccination shows poor results, a fact that can be explained at least partially by an immunosuppressive tumor microenvironment that is abundant in galectin-3. " 11/01/2015 - "Parafibromin expression, galectin-3 negativity, and a Ki-67 proliferation index under 1% were estimated as beneficial in the differential diagnosis of difficult parathyroid tumors." 11/01/2013 - "There was no significant difference in the triage efficacy of FNAC, galectin-3 expression, and the prevalence of somatic mutations between encapsulated and infiltrative tumors. " 01/01/2008 - "At 6 hrs post-injection galectin-3 expressing tumors were correctly visualized, while the whole-body activity had essentially cleared. " 10/23/2015 - "Immunochemical studies showed that the distribution of galectin-3 coincided with that of MUC1 in various human tumor tissues but not in human nonmalignant tissues, and the level of galectin-3 retained on the surface of various cancer cells paralleled that of MUC1. "
2.	Inflammation 01/01/2011 - "In a previous study, we demonstrated that treatment of chronic asthmatic mice with gene therapy using plasmid encoding galectin-3 (Gal-3) led to an improvement in Th2 allergic inflammation. " 02/01/2010 - "Further, reduction in approximately 3 folds of galectin-3, an inflammatory marker suggests gastro protection against acid induced inflammation and gastric wall damages. " 01/01/2009 - "We investigated whether extracellular galectin-3 could participate in the phagocytic clearance of apoptotic neutrophils by macrophages, a process of crucial importance for termination of acute inflammation. " 12/01/2013 - "This study compared the roles of galectin-3 and receptor for AGEs (RAGE), two ALEs/AGEs-receptors with diverging effects on inflammation and bone metabolism, in the process of vascular calcification. " 10/01/2008 - "The aim of this study was evaluate the role of galectin-3 in the inflammation triggered by IRI. "
3.	Adenoma (Adenomas) 06/01/2012 - "Intracytoplasmatic expression of galectin-3 was positive in 10 (31%) cases of follicular adenoma and 8 (80%) cases of Hürthle cell adenoma. " 03/01/2011 - "Immunohistochemical staining for parafibromin, APC, and galectin-3 suggested the malignant potential of the atypical adenoma removed during the patient's original operation, which is believed to be the source of her metastatic disease. " 12/01/2008 - "Two cases with follicular adenomas were negative for Galectin-3. " 03/01/2007 - "All adenomas resulted negative for galectin-3 immunostaining. " 09/01/2005 - "But all three eosinophilic follicular adenomas were diffusely or focally positive for galectin-3. "
4.	Carcinoma (Carcinomatosis) 01/01/2013 - "Clear cell carcinomas of the ovary: a multi-institutional study of 129 cases in Korea with prognostic significance of Emi1 and Galectin-3." 08/01/2005 - "Galectin-3 expression in follicular tumours: an immunohistochemical study of its use as a marker of follicular carcinoma." 11/01/2002 - "Furthermore, studies of RPMI-2650 variants suggest that galectin-3 expression correlates with nasal carcinoma cell invasiveness. " 07/20/2000 - "In our study, we have examined the expression of galectin-3 in a population of 145 prostate carcinoma samples using immunohistochemistry. " 10/06/2014 - "Increased expression of membrane-bound galectin-3 by prostate carcinoma cell has been found to correlate with more poorly differentiated and increased metastatic potential. "
5.	Neoplasm Metastasis (Metastasis) 08/01/1998 - "Reduction in galectin 3 levels was associated with a marked decrease in liver colonization and spontaneous metastasis by LSLiM6 and HM7 cells, whereas up-regulation of galectin 3 resulted in increased metastasis by LS174T cells. " 01/15/2011 - "In the present study, we have provided clinical evidence that the level of galectin-3 is significantly elevated in the sera of PC patients with metastatic disease compared with patients without metastasis (P = 0.04) and healthy controls (P = 0.00001). " 12/01/2015 - "Our data indicates that complete absence of endogenous host galectin-3 facilitates lung metastasis of B16F10 cells in mice, which may be contributed by dysregulated immune responses resulting from decreased NK cytotoxicity, disturbed serum Th1, Th2, Th17 cytokine milieu, reduced serum IFN-γ levels and attenuation of splenic STAT1 mediated IFN-γ signalling in Gal-3(-/-) mice. " 10/01/2015 - "It has recently been demonstrated that galectin-3, a multifunctional β-galactoside-binding, is significantly upregulated in OS tissues, and is correlated with its progression and metastasis. " 10/01/2015 - "MMP-9 and galectin-3 could be used as a guide for prognosis of HCC since they may play a role in HCC progression and metastasis. "

Related Drugs and Biologics

1.	Galectins (Galectin)
2.	papillary Thyroid cancer
3.	Galectin 3 (LGALS3)
4.	Mucins
5.	Galectin 1 (LGALS1)
6.	Messenger RNA (mRNA)
7.	Biological Markers (Surrogate Marker)
8.	Collagen
9.	Factor IX (PTC)
10.	Brachyury protein (Brachyury)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Cardiac Resynchronization Therapy
4.	Defibrillators (Defibrillator)
5.	Immunomodulation