Galectin 2 (LGALS2)

09/01/2007 - "LGALS2 functional variant rs7291467 is not associated with susceptibility to myocardial infarction in Caucasians."
08/01/2007 - "A putative risk genotype of the polymorphism in the LGALS2 gene (rs7291467; 3279T/C) was not associated with myocardial infarction (OR 0.98, 95% CI 0.83-1.16; P = 0.84). "
03/01/2007 - "Lack of association between LTA and LGALS2 polymorphisms and myocardial infarction in Japanese and Korean populations."
10/01/2016 - "Galectin-2 (Gal-2) plays a role in cancer, myocardial infarction, immune response, and gastrointestinal tract diseases. "
03/01/2009 - "Several genes involved in the lymphotoxin-alpha cascade (LTA, LGALS2, and PSMA6) have been linked with the risk of myocardial infarction. "

12/01/2008 - "Our study provides evidence that galectin-2 induces apoptosis in vivo and ameliorates acute and chronic murine colitis. "
12/01/2008 - "Galectin-2 induces apoptosis of lamina propria T lymphocytes and ameliorates acute and chronic experimental colitis in mice."
12/01/2008 - "During colitis, galectin-2 expression was reduced, but could be restored to normal levels by immunosuppressive treatment. "
05/01/2009 - "Since it has been demonstrated that galectin-2 regulates cell-mediated inflammatory bowel disease and colitis in mice, we intended to investigate the role of galectin-2 in inflammatory cutaneous T cell-mediated immune responses. "
12/01/2008 - "Here, we investigate the potential therapeutic effect of galectin-2 in experimental colitis. "

04/01/2009 - "In the present study, we examined whether the LGALS2 3279TT homozygote variant alone can influence the prevalence of ischaemic stroke, and whether it can interact somehow with the disadvantageous LTA 252GG homozygote variant. "
06/01/2016 - "Genetic association between inflammatory genes (IL-1α, CD14, LGALS2, PSMA6) and risk of ischemic stroke: A meta-analysis."
04/01/2009 - "The combination of the LGALS2 3279TT and LTA 252GG homozygote was significantly less frequent in the ischemic stroke group (1.56%) than in the controls (5.94%, p<0.00187; overall stroke group: crude OR: 0.25, 95% CI: 0.1-0.64; adjusted OR: 0.03, 95% CI: 0.025-0.71). "
04/01/2009 - "Galectin-2 3279TT variant protects against the lymphotoxin-alpha 252GG genotype associated ischaemic stroke."
06/01/2016 - "Very few number of studies have been published in the context of the association between Interleukin-1α(IL-1α), CD14 cell surface glycoprotein (CD14), Galectin-2-encoding gene (LGALS2)and proteasome subunit type 6 (PSMA6) gene polymorphisms with susceptibility to ischemic stroke (IS). "

01/01/2022 - "Mechanistic studies demonstrated that tumor cell-intrinsic Lgals2 induced the increased number of tumor-associated macrophages, as well as the M2-like polarization and proliferation of macrophages through the CSF1/CSF1R axis, which resulted in the immunosuppressive nature of the TNBC microenvironment. "
09/01/2022 - "These data indicate that LGALS2 suppresses PTC progression via PI3K/AKT pathway activation, suggesting that LGALS2 offers value as a treatment target for patients with this cancer type."
09/01/2022 - "Western immunoblotting and real-time quantitative polymerase chain reaction (qPCR) were used to compare LGALS2 expression levels in tumor and paracancerous tissues from PTC patients. "
01/01/2022 - "Next, we found that the expression level of LGALS2 gradually decreased with tumor progression in DLBCL and that increased expression of LGALS2 predicted a better prognosis for DLBCL patients. ssGSEA revealed that LGALS2 is involved in immune-related pathways and has a significant regulatory effect on human immune responses. "
01/01/2022 - "Blockade of LGALS2 using an inhibitory antibody successfully arrested tumor growth and reversed the immune suppression. "

12/25/2022 - "A number of studies have also suggested the involvement of galectin-2 in tissue inflammation, immune response and cell apoptosis. "
05/01/2009 - "Here we show that galectin-2 is expressed in murine skin and is up-regulated upon cutaneous inflammation. "
01/01/2006 - "This genetic substitution seemed to affect the transcriptional level of galectin-2, which led to altered secretion of LTA, thereby affecting the degree of inflammation. "
05/06/2004 - "This genetic substitution affects the transcriptional level of galectin-2 in vitro, potentially leading to altered secretion of LTA, which would then affect the degree of inflammation; however, its relevance to other populations remains to be clarified. "
03/31/2020 - "The findings contribute to the emerging understanding of the role of immunomodulation and inflammation in GDM and of galectin-2 itself. "