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Galectin 1 (LGALS1)

A galectin found abundantly in smooth muscle (MUSCLE, SMOOTH) and SKELETAL MUSCLE and many other tissues. It occurs as a homodimer with two 14-kDa subunits.

Also Known As:

LGALS1; Galactoside-Binding Lectin 1; Galaptin; Galectin-1; L-14 Lectin; L1-Lac Lectin; Galactoside Binding Lectin 1; L1 Lac Lectin; Lectin 1, Galactoside-Binding; Lectin, L-14; Lectin, L1-Lac

Networked: 530 relevant articles (17 outcomes, 74 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Lectins: 1537
    - Galectins: 543
      - Galectin 1: 530
        human LGALS1 protein

Experts

1.	Rabinovich, Gabriel A: 38 articles (10/2015 - 01/2002)
2.	Gabius, Hans-Joachim: 33 articles (09/2014 - 01/2002)
3.	André, Sabine: 26 articles (09/2014 - 01/2002)
4.	Kiss, Robert: 24 articles (02/2014 - 02/2002)
5.	Kaltner, Herbert: 18 articles (12/2012 - 01/2002)
6.	Baum, Linda G: 16 articles (09/2015 - 06/2003)
7.	Decaestecker, Christine: 16 articles (07/2014 - 02/2002)
8.	Lefranc, Florence: 15 articles (02/2014 - 07/2002)
9.	Kaltner, H: 13 articles (01/2009 - 04/2000)
10.	Ilarregui, Juan M: 11 articles (10/2015 - 03/2004)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2011 - "We show for the first time that the single agent, TDG, concurrently prevents many tumor promoting effects of galectin-1 on angiogenesis, immune dysregulation and protection against oxidative stress, providing a potent and novel small molecule as an anti-cancer drug." 03/10/2012 - "In conclusion, synergistic targeting of α(v)β(3) and galectin-1 improved the specificity of the association of the liposomal contrast agent to tumor endothelium in vivo, providing therefore a more reliable MRI readout of the angiogenic activity." 10/01/2014 - "Mounting evidence suggests that tumor and endothelial cells may utilize galectin-1 (Gal-1) for protection against radiation through several mechanisms. " 01/01/2015 - "The aim of this study was to determine the phenotype of galectin-1, -3 and -9 expressing cells and the association with clinico-pathological parameters in cervical cancer. " 08/01/2014 - "The objective of our study was to define the effect of extracellular matrix (ECM) produced by normal dermal or cancer-associated fibroblasts exposed to adhesion/growth-regulatory lectin galectin-1 on human umbilical vein endothelial cells (HUVECs). "
2.	Neoplasm Metastasis (Metastasis) 02/20/2015 - "Finally, a retrospective study revealed that galectin-1 levels in blood circulation negatively correlates with overall survival and positively correlates with lymph node metastasis of the patients. " 05/01/2014 - "Immunohistochemical analysis of galectin-1 expression might be useful for identifying patients with a high risk of distant metastasis and for prompting timely adjuvant systemic therapy for patients with aggressive NPC. " 01/01/2013 - "Galectin 1 expression was significantly correlated with the depth of invasion in the cervix (P=.015) and lymph node metastasis (P=.045) on univariate analysis. " 08/01/2012 - "The analysis of correlation of the overexpression with clinicopathology in human cases suggested that high expression of galectin-1 was associated with advanced stage and metastasis and with shorter cumulative overall survival of the patients. " 03/01/2012 - "Galectin-1 has recently emerged as a significant protein produced by tumour cells to promote tumour development, angiogenesis and metastasis and consequently represents an important target to inhibit. "
3.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2015 - "Knockdown of galectin-1 in pancreatic cancer-associated fibroblasts dramatically reduced cell migration and invasion. " 01/01/2015 - "The results from our study suggested that PRELP, LGALS1 and RPS8 might be significant prognostic factors, and RPS8 and LGALS1 could be potential therapeutic targets to improve pancreatic cancer survival if further validated. " 05/15/2012 - "Our study suggests that the overexpression of Galectin-1 in PSCs induced T cell apoptosis and Th2 cytokine secretion, which may regulate PSC-dependent immunoprivilege in the pancreatic cancer microenvironment. " 07/01/2015 - "hCaPSC-derived galectin-1 enhanced apoptosis and anergy of T cells in pancreatic cancer, which contributes to the immune escape of pancreatic cancer cells. " 07/01/2015 - "Immunohistochemical staining indicated that galectin-1 and CD3 were more highly expressed in pancreatic cancer tissue. "
4.	Inflammation 01/01/2015 - "Protective effects of the galectin-1 protein on in vivo and in vitro models of ocular inflammation." 12/01/2013 - "Our results suggest that galectin-1 could be an essential mediator in the control of macrophage function during the resolution of inflammation. " 08/01/2013 - "Here we show that treatment of apoptotic cells modulates expression of inflammation- and tolerance-associated molecules including Gr-1, B220, CD205 and galectin-1 on bone marrow-derived DCs. " 01/01/2013 - "Galectin-1 (Gal-1), an evolutionarily conserved β-galactoside-binding lectin, plays essential roles in the control of inflammation and neovascularization. " 08/24/2012 - "Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegeneration."
5.	Melanoma (Melanoma, Malignant) 09/01/2012 - "Galectin-1 in melanoma biology and related neo-angiogenesis processes." 01/15/2001 - "Galectin-1 also induced aggregation of a human melanoma cell line, A375, in a carbohydrate-dependent manner, and this appeared to be mediated, at least in part, by 90K expressed on A375 cells, since it was inhibitable by a specific anti-90K monoclonal antibody. " 09/26/2011 - "In the present article, we review the biochemical and molecular biology-related pathways controlled by galectin-1, which are actually beneficial for melanoma and glioma cells, and therefore detrimental for melanoma and glioma patients." 12/01/2011 - "Galectin-1 as an oncotarget in gliomas and melanomas." 12/28/2010 - "Using a galectin-1 polyclonal antibody, high levels of galectin-1 protein were shown to be expressed by breast cancer cells established from FVB/N MMTV-c-neu mice as well as by the B16F10 melanoma cell line. "

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	thiodigalactoside
3.	Galectin 3 (LGALS3)
4.	DNA (Deoxyribonucleic Acid)
5.	Immunoglobulin G (IgG)
6.	Concanavalin A
7.	heparin-binding EGF-like growth factor (HB-EGF)
8.	galactose-binding protein
9.	Galactosides
10.	Carrier Proteins (Binding Protein)

Related Therapies and Procedures

1.	Immunomodulation
2.	Heterologous Transplantation (Xenotransplantation)
3.	Radiotherapy
4.	Immunotherapy
5.	Drug Therapy (Chemotherapy)