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Pertussis Toxin

Subscribe to New Research on Pertussis Toxin

One of the virulence factors produced by BORDETELLA PERTUSSIS. It is a multimeric protein composed of five subunits S1 - S5. S1 contains mono ADPribose transferase activity.

Also Known As:

Histamine-Sensitizing Factor; Islets-Activating Protein; Lymphocytosis-Promoting Factor; Histamine Sensitizing Factor; Islet Activating Protein; Islets Activating Protein; Lymphocytosis Promoting Factor; Pertussis Toxin, IAP; Toxin, IAP Pertussis; Toxin, Pertussis; IAP Pertussis Toxin; Islet-Activating Protein; Pertussigen

Networked: 1274 relevant articles (26 outcomes, 103 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Carbonetti, Nicholas H: 12 articles (11/2015 - 11/2003)
2.	Mooi, Frits R: 8 articles (01/2014 - 06/2002)
3.	Xing, Dorothy: 7 articles (03/2014 - 11/2002)
4.	Fry, Norman K: 7 articles (01/2014 - 06/2004)
5.	Zaĭtsev, E M: 6 articles (07/2014 - 05/2006)
6.	Harrison, Timothy G: 6 articles (01/2014 - 06/2004)
7.	Watanabe, Mineo: 5 articles (09/2015 - 01/2002)
8.	Cherry, James D: 5 articles (09/2014 - 02/2004)
9.	Locht, Camille: 5 articles (06/2014 - 04/2002)
10.	Versteegh, Florens G A: 5 articles (01/2014 - 08/2006)

Related Diseases

1.	Whooping Cough (Pertussis) 08/01/2004 - "pertussis was based on the amplification of a section of the IS481 insertion sequence and confirmation of positive results was based on a sequence of the pertussis toxin promoter region. " 10/01/1987 - "pertussis strains were utilized to study the biogenesis of pertussis toxin. " 12/01/2015 - "pertussis lipooligosaccharide (LOS) is suppressed by pertussis toxin (PTX). " 11/01/2015 - "Pertussis toxin (PT) is a multisubunit protein toxin secreted by Bordetella pertussis, the bacterial agent of the disease pertussis or whooping cough. " 11/01/2015 - "Contribution of pertussis toxin to the pathogenesis of pertussis disease."
2.	Infection 01/01/1992 - "Nontoxic analogs of pertussis toxin (PT), produced by in vitro mutagenesis of the tox operon, are immunogenic and protective against infection by Bordetella pertussis. " 12/01/1990 - "Mechanism of pertussis toxin B oligomer-mediated protection against Bordetella pertussis respiratory infection." 10/01/1998 - "Bordetella pertussis infection was documented by culture of the organism in the study child or in a household contact or by a significant antibody response to pertussis toxin determined by enzyme-linked immunosorbent assay. " 08/01/1993 - "Although the chick embryo serum neutralization studies confirm observations of mouse intracerebral infection studies that antibody to pertussis toxin is not an absolute requirement for prevention of infection with B. " 12/01/2012 - "Pertussis toxin exacerbates and prolongs airway inflammatory responses during Bordetella pertussis infection."
3.	Diphtheria 01/02/2016 - "However, blunting was noticed for infant diphtheria and pertussis toxin vaccine responses (p<0.001) in the infants from vaccinated women after the primary vaccination schedule (weeks 8,12 and 16). " 05/01/2011 - "Anti-diphtheria, -tetanus, and -pertussis toxin levels were similar in all groups. " 04/01/2011 - "There was a significant increase in the odds that newborns from mothers who received Tdap during pregnancy have antibodies that may provide protection against diphtheria (P = .0141), pertussis toxin (P < .0001), and fimbriae 2/3 (P = .0146). " 09/01/2008 - "Compared with the control group, infants in the experimental group demonstrated significantly lower geometric mean antibody concentrations for pertussis toxin and pertactin 6, 7, and 18 months, for fimbrae at 6, 7, 17, and 18 months, and for FHA at 18 months, and lower geometric mean antibody concentrations for diphtheria at 7 months. " 12/01/2015 - "Antibody responses to pertussis toxin (PT), filamentous hemagglutinin (FHA), fimbriae 2 + 3 (FIMs), diphtheria, tetanus, Hib, MCC and PCV13 serotypes were compared to responses in a historical cohort of 246 infants born to mothers not vaccinated in pregnancy. "
4.	Cholera 01/01/1997 - "Crude cell membranes were isolated from the annular pad, cortical fibers, and nuclear fibers of adult chickens and subjected to cholera and pertussis toxin-mediated ribosylation reactions. " 09/15/1995 - "Inhibition of chemokine-induced increase of [Ca2+]i by cholera or pertussis toxin indicated that MCP-1 and MCP-2 activate monocytes through different intracellular pathways. " 04/01/1995 - "In cells treated with either cholera or pertussis toxin Golgi redistribution into the ER shows a 50-fold lower requirement for cytosolic factors than in untreated cells. " 04/01/1994 - "Isolation of Gi and Gs responses was accomplished by incubating cells with cholera or pertussis toxin, respectively. " 11/01/1992 - "Furthermore, the blockade of the [3H]-CGS21680 binding by both cholera and pertussis toxin further supports the view that the subtypes present in BBM are neither A1 nor A2. "
5.	Tetanus 01/01/1996 - "It was concluded that pertussis toxin has a vaccine dose-dependent adjuvant effect on the potency of tetanus toxoïd resulting in high potency values when determined by ToBI procedure. " 01/01/1996 - "Therefore, the effect of pertussis toxin (PT) on the potency of the tetanus component in the serological assay was examined. " 05/01/2011 - "Anti-diphtheria, -tetanus, and -pertussis toxin levels were similar in all groups. " 02/04/2011 - "Purified B-cells were characterized by FACS-analysis and after polyclonal stimulation memory B-cells were detected by ELISPOT-assays specific for pertussis toxin, filamentous haemagglutinin, pertactin and tetanus. " 02/01/1994 - "In addition, it was capable of inducing strong protection against tetanus and some protection against pertussis, as well as eliciting a pertussis toxin-neutralizing antibody response. "

Related Drugs and Biologics

1.	Vaccines
2.	Antibodies
3.	GTP-Binding Proteins (G-Protein)
4.	Hemagglutinins (Hemagglutinin)
5.	pertactin
6.	Immunoglobulin G (IgG)
7.	Adenosine Diphosphate (ADP)
8.	Acetylcholine (Acetylcholine Chloride)
9.	Antigens
10.	Pertussis Vaccine

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Injections
3.	Cystectomy
4.	Subcutaneous Injections
5.	Aftercare (After-Treatment)