beta Subunit Thyrotropin (Thyrotropin-beta)

The beta subunit of thyroid stimulating hormone, thyrotropin. It is a 112-amino acid glycopolypeptide of about 16 kD. Full biological activity of TSH requires the non-covalently bound heterodimers of an alpha and a beta subunit.

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Networked: 112 relevant articles (2 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pohlenz, Joachim: 2 articles (01/2014 - 08/2004)
2.	Ikeda, Hidetoshi: 2 articles (06/2008 - 01/2003)
3.	Refetoff, Samuel: 2 articles (08/2004 - 04/2002)
4.	Heinrich, Juan J: 2 articles (01/2004 - 06/2003)
5.	Domené, Horacio M: 2 articles (01/2004 - 06/2003)
6.	Chiesa, Ana: 2 articles (01/2004 - 06/2003)
7.	Grüters, Annette: 2 articles (01/2003 - 10/2002)
8.	Biebermann, Heike: 2 articles (01/2003 - 10/2002)
9.	Klotz, Cherise: 1 article (01/2014)
10.	Hermanns, Pia: 1 article (01/2014)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1992 - "A cell line (alpha TSH) derived from the transplantable mouse thyrotropic tumor MGH101A, which no longer expresses the TSH beta-subunit gene but continues to secrete large amounts of alpha-subunit, was used as a model to study alpha-subunit gene expression independent from the TSH beta-subunit gene and was compared with the expression in TSH-secreting TtT97 tumors. " 04/16/1991 - "Our previous studies demonstrated TRH stimulation of TSH beta gene expression in rat pituitary cell cultures and GH3 tumor cells in a transient expression assay. " 12/01/1987 - "The current studies reveal that expression of the mouse TSH beta-subunit gene in the pituitary gland and TtT97 murine thyrotropic tumor results in multiple mRNAs which arise by alternative splicing. " 09/01/2004 - "The tumor cells displayed positive reaction for TSH (beta-subunit). " 10/05/1993 - "Transiently transfected Pit-1T increases TSH beta promoter activity in TtT-97 thyrotropic tumor cells, whereas additional Pit-1 has no effect. "
2.	Hyperthyroidism 04/01/1988 - "A significant reduction in the pituitary TSH-beta mRNA levels was observed in all NTI models and hyperthyroidism, while TSH-beta mRNA was increased in thyroidectomized rats. " 12/01/1996 - "Pituitary adenomas and activating mutations of the TSH receptor gene (Parma et al., 1993) cause hyperthyroidism and TSH beta gene defects (Hayashizaki et al., 1989) and inactivating mutations of the TSH receptor gene (Sunthornthepvarakul et al., 1995) cause hypothyroidism. "
3.	Adenoma (Adenomas) 05/01/1998 - "Nine clinically non-functioning adenomas expressed Pit-1 as well as GH, PRL and/or TSH beta, thus having somatomammotrophic or thyrotrophic properties, 3 of which overlapped with the above DAX-1-expressing adenomas. " 04/01/1998 - "TSH beta-positive adenoma cells were less frequently seen than GH-positive adenoma cells. " 12/01/1994 - "The proportion of TSH beta-positive cells ranged from 20% to 75% of adenoma cells. " 02/01/1993 - "These adenomas were composed of enlarged round cells which were positive only for GH, hGRF, PRL and TSH beta SU. " 01/20/1987 - "The immunoperoxidase technique revealed TSH beta in the cytoplasm of some adenoma cells. "
4.	Pituitary Neoplasms (Pituitary Adenoma) 08/01/1995 - "The tissues from pituitary adenomas were obtained at the time of transsphenoidal surgery and revealed immunohistochemically the expression of alpha-subunit and TSH beta in all patients. " 09/05/1989 - "Reduced expression of TSH beta constructs was also found in GH3 and GH4 pituitary tumor lines. " 06/01/1989 - "Pituitary adenoma tissue obtained at the time of transsphenoidal surgery immunostained weakly with anti-TSH beta serum and strongly with anti-alpha-subunit serum. " 06/01/1990 - "These findings support the idea that some pituitary adenomas in acromegaly cosecrete GH and either alpha subunit or TSH-beta subunit." 11/01/2005 - "Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line."
5.	Hypothyroidism 06/01/2003 - "Congenital secondary hypothyroidism due to a mutation C105Vfs114X thyrotropin-beta mutation: genetic study of five unrelated families from Switzerland and Argentina." 09/01/2010 - "Two novel mutations of the TSH-beta subunit gene underlying congenital central hypothyroidism undetectable in neonatal TSH screening." 06/01/2010 - "New cases of isolated congenital central hypothyroidism due to homozygous thyrotropin beta gene mutations: a pitfall to neonatal screening." 05/01/2006 - "Initially elevated TSH and congenital central hypothyroidism due to a homozygous mutation of the TSH beta subunit gene: case report and review of the literature." 08/01/2004 - "Four new cases of congenital secondary hypothyroidism due to a splice site mutation in the thyrotropin-beta gene: phenotypic variability and founder effect."

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Growth Hormone (Somatotropin)
3.	DNA (Deoxyribonucleic Acid)
4.	beta Subunit Thyrotropin (Thyrotropin-beta)
5.	Thyrotropin (Thyroid-Stimulating Hormone)
6.	Hormones
7.	beta Subunit Luteinizing Hormone
8.	Complementary DNA (cDNA)
9.	Somatostatin Receptors (Somatostatin Receptor)
10.	Octreotide (Sandostatin)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)