Calnexin

A lectin found in ENDOPLASMIC RETICULUM membranes that binds to specific N-linked OLIGOSACCHARIDES found on newly synthesized proteins. It may play role in PROTEIN FOLDING or retention and degradation of misfolded proteins in the endoplasmic reticulum.

Also Known As:

Networked: 145 relevant articles (1 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ferrone, Soldano: 5 articles (10/2017 - 12/2005)
2.	Michalak, Marek: 4 articles (12/2020 - 01/2004)
3.	Jung, Joanna: 3 articles (12/2020 - 11/2011)
4.	Molinari, Maurizio: 3 articles (01/2018 - 11/2002)
5.	Abhyankar, Dhiraj: 3 articles (03/2004 - 09/2003)
6.	Biswas, Jyotirmay: 3 articles (03/2004 - 09/2003)
7.	Krishnakumar, Subramanian: 3 articles (03/2004 - 09/2003)
8.	Cheng, Minrong: 2 articles (02/2022 - 01/2021)
9.	Gao, Shuhua: 2 articles (02/2022 - 01/2021)
10.	Shao, Ying: 2 articles (02/2022 - 01/2021)

Related Diseases

1.	Prion Diseases (Transmissible Spongiform Encephalopathies) 10/01/2010 - "These results implied that calnexin is potentially beneficial for the resistance of prion diseases."
2.	Neoplasms (Cancer) 01/01/2021 - "At these later time points, increased Bax activation in cancer cells suggested that MitoBax may be controlled by DDIT3 or by Calnexin. " 10/01/2019 - "SMAR1 favors immunosurveillance of cancer cells by modulating calnexin and MHC I expression." 09/03/2015 - "Finally, HCAb2 specifically targeted calnexin negative xenograft tumor cells. " 06/01/2007 - "LMP2, LMP7, calnexin, beta2-microglobulin-free heavy chain (HC) and beta2-microglobulin were down-regulated or undetectable in Mb lesions, but not in astrocytic tumors or normal fetal cerebellum. " 01/01/2019 - "Thus, this work uncovers a mechanism by which T-cell antitumor responses are regulated by calnexin in tumor cells and suggests that calnexin might serve as a potential target for the improvement of antitumor immunotherapy."
3.	Melanoma (Melanoma, Malignant) 01/20/2004 - "Our data suggest that chaperone-downregulation, particularly calnexin-downregulation, may contribute to the metastatic phenotype of melanoma cells in vivo. " 01/20/2004 - "Metastatic melanoma lesions exhibited significant downregulation of calnexin as compared to primary melanoma lesions. " 01/20/2004 - "Differential downregulation of endoplasmic reticulum-residing chaperones calnexin and calreticulin in human metastatic melanoma." 08/01/1993 - "We have recently identified a gene encoding a calnexin-like protein (p90) by the immunoscreening of a human melanoma cDNA library, using a rabbit anti-human melanosomal antibody. " 01/20/2004 - "In the present study, we compared melanoma lesions representing different stages of tumor progression with regard to the expression of calnexin and calreticulin in tumor cells by means of immunohistochemistry. "
4.	Infections 01/01/2022 - "Despite observing Golgi fragmentation by immunofluorescence during RV-C15 infection as previously reported for other RVs, a high ratio of calnexin-dsRNA colocalization implicated the endoplasmic reticulum as the primary site for RV-C15 replication in HAE. " 01/01/2019 - "Importantly, VAPB knockdown did not alter pUL34, calnexin or GM-130 localization during infection, arguing against an indirect effect of VAPB on cellular vesicles and trafficking. " 04/08/2015 - "Infection with divergent ascomycetes, including dimorphic fungi, opportunistic molds, and the agent causing white nose syndrome in bats, induces expansion of calnexin-specific CD4(+) T cells. " 10/01/2012 - "abortus cstA mutant displayed peculiar trafficking, with reduced association with LAMP1 and Calnexin 12 h post-infection in HeLa cells. " 09/01/2006 - "Twenty-four hours after infection, microcolonies of live bacteria were observed in the perinuclear area colocalizing with calnexin. "
5.	Vesicular Stomatitis 10/21/1994 - "Biosynthetic labeling was used to study the interactions of two chaperones, BiP and calnexin, with vesicular stomatitis virus (VSV) glycoprotein (G protein). " 01/01/2015 - "Effect of ionomycin on interaction of calnexin with vesicular stomatitis virus glycoprotein is cell type-specific." 03/12/1999 - "To analyze the role of glucose trimming and reglucosylation in the binding of substrate proteins to calnexin in the endoplasmic reticulum (ER) of living cells, we made use of the thermosensitive vesicular stomatitis virus tsO45 glycoprotein (G protein). " 10/01/2022 - ": 3-MA: 3-methyladenine; 4-PBA: 4-phenylbutyrate; ACTB: β-actin; ATF: activating transcription factor; ATG: autophagy-related; BafA1: bafilomycin A1; BDBV: Bundibugyo ebolavirus; CALR: calreticulin; CANX: calnexin; CHX: cycloheximide; CMA: chaperone-mediated autophagy; ConA: concanamycin A; CRISPR: clusters of regularly interspaced short palindromic repeats; Cas9: CRISPR-associated protein 9; dsRNA: double-stranded RNA; EBOV: Zaire ebolavirus; EDEM: ER degradation enhancing alpha-mannosidase like protein; EIF2AK3/PERK: eukaryotic translation initiation factor 2 alpha kinase 3; Env: envelope glycoprotein; ER: endoplasmic reticulum; ERAD: ER-associated protein degradation; ERN1/IRE1: endoplasmic reticulum to nucleus signaling 1; GP: glycoprotein; HA: hemagglutinin; HDAC6: histone deacetylase 6; HMM: high-molecular-mass; HIV-1: human immunodeficiency virus type 1; HSPA5/BiP: heat shock protein family A (Hsp70) member 5; IAV: influenza A virus; IP: immunoprecipitation; KIF: kifenesine; Lac: lactacystin; LAMP: lysosomal associated membrane protein; MAN1B1/ERManI: mannosidase alpha class 1B member 1; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MARV: Marburg virus; MLD: mucin-like domain; NHK/SERPINA1: alpha1-antitrypsin variant null (Hong Kong); NTZ: nitazoxanide; PDI: protein disulfide isomerase; RAVV: Ravn virus; RESTV: Reston ebolavirus; SARS-CoV: severe acute respiratory syndrome coronavirus; SBOV: Sudan ebolavirus; sGP: soluble GP; SQSTM1/p62: sequestosome 1; ssGP: small soluble GP; TAFV: Taï Forest ebolavirus; TIZ: tizoxanide; TGN: thapsigargin; TLD: TXN (thioredoxin)-like domain; Ub: ubiquitin; UPR: unfolded protein response; VLP: virus-like particle; VSV: vesicular stomatitis virus; WB: Western blotting; WT: wild-type; XBP1: X-box binding protein 1."

Related Drugs and Biologics

1.	Calreticulin
2.	Proteins (Proteins, Gene)
3.	Glycoproteins (Glycoprotein)
4.	Adenosine Triphosphate (ATP)
5.	GTP-Binding Proteins (G-Protein)
6.	Antigens
7.	transporter associated with antigen processing (TAP)
8.	Lectins
9.	Lamins
10.	Ursodeoxycholic Acid (Urso)

Related Therapies and Procedures

1.	Ligation
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)