C-Type Lectins (C-Type Lectin)

A class of animal lectins that bind to carbohydrate in a calcium-dependent manner. They share a common carbohydrate-binding domain that is structurally distinct from other classes of lectins.

Also Known As:

Networked: 418 relevant articles (6 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Geijtenbeek, Teunis B H: 18 articles (01/2014 - 06/2002)
2.	van Kooyk, Yvette: 11 articles (03/2009 - 01/2004)
3.	Brown, Gordon D: 10 articles (02/2014 - 01/2006)
4.	Wang, Lingling: 6 articles (06/2015 - 01/2009)
5.	Zhang, Huan: 6 articles (06/2015 - 01/2009)
6.	Song, Linsheng: 6 articles (06/2015 - 01/2009)
7.	Gringhuis, Sonja I: 6 articles (04/2012 - 08/2007)
8.	Lin, Xin: 5 articles (06/2015 - 12/2011)
9.	Wang, Jin-Xing: 5 articles (09/2014 - 10/2009)
10.	Wang, Xian-Wei: 5 articles (09/2014 - 10/2009)

Related Diseases

1.	Infection 01/01/2013 - "LCs express the C-type lectin receptor langerin, which provides protection against HIV-1 infection. " 11/01/2015 - "Dendritic cell expression of the C-type lectin receptor CD209a: A novel innate parasite-sensing mechanism inducing Th17 cells that drive severe immunopathology in murine schistosome infection." 06/01/2015 - "[The Immunomodulatory Role of C-type Lectin Receptors in Parasitic Infection]." 01/01/2015 - "Additionally, some arthropod C-type lectins were recently identified as key susceptibility factors that directly interact with multiple viruses and then facilitate infection. " 01/01/2015 - "The macrophage-inducible C-type lectin Mincle has recently been identified to be a pattern recognition receptor sensing mycobacterial infection via recognition of the mycobacterial cell wall component trehalose-6',6-dimycolate (TDM). "
2.	Neoplasms (Cancer) 07/01/2009 - "Currently, DC-specific C-type lectins are considered potential target in anti-tumor clinical trials. " 03/01/2015 - "Despite the ability of C-type lectin domains (CTLD) to modulate cell-cell adhesion, it is not known if they modulate epithelial adhesion in EMT and tumor progression. " 01/01/2015 - "Following activation, NK cells show an up-regulated expression of activatory C-type lectin receptors, such as CD94/NKG2C, NKG2D, and natural cytotoxicity receptors (NCRs; NKp44, NKp46, and NKp30) and thereby gain the capacity to kill mHsp70-positive tumor cells. " 01/01/2015 - "Targeting C-Type Lectin Receptors for Cancer Immunity." 12/01/2014 - "Aggrus is frequently overexpressed in several types of tumors and enhances platelet aggregation by interacting with the platelet receptor C-type lectin-like receptor 2 (CLEC-2). "
3.	Autoimmune Diseases (Autoimmune Disease) 01/01/2013 - "Single nucleotide polymorphisms (SNPs) in the C-type lectin-like domain family 16A (CLEC16A) gene were among the first non-HLA genetic variants that were confirmed to be associated with MS. Fine-mapping has indicated a primary association in MS and also other autoimmune diseases to intronic CLEC16A SNPs. " 01/01/2012 - "CLEC16A, C-type lectin domain family 16, member A was recently found to be associated with inflation process in the autoimmune diseases. " 06/01/2015 - "The C-type lectin CLEC16A gene is located at 16p13, a susceptibility locus for several autoimmune diseases, including multiple sclerosis. " 08/01/2011 - "The QTL on chromosome 6 displays the highest LOD score (5.4) and contains the C-type lectin domain family 4 member a2 in its peak region, which encodes a receptor protein of dendritic cells that has previously been implicated in autoimmune diseases such as Sjogren's syndrome. " 04/01/2015 - "A better understanding of tumor 'glycan codes' as deciphered by lectins, such as siglecs, selectins, C-type lectins and galectins, may lead to novel treatment strategies, not only in cancer, but also in autoimmune disease or transplantation. "
4.	Chronic Obstructive Pulmonary Disease (COPD) 01/01/2013 - "We have previously shown that the defective ability of alveolar macrophages (AM) to phagocytose apoptotic cells ('efferocytosis') in chronic obstructive pulmonary disease/emphysema (COPD) could be therapeutically improved using the C-type lectin, mannose binding lectin (MBL), although the exact mechanisms underlying this effect are unknown. "
5.	Pulmonary Eosinophilia (Eosinophilic Pneumonia) 06/01/2005 - "Intranasal treatment with SP-D or rhSP-D (a recombinant fragment of human SP-D containing trimeric C-type lectin domains) was effective in rescuing the Afu-sensitized DKO mice, while SP-A-treated Afu-sensitized AKO mice showed several-fold elevated levels of IL-13 and IL-5, resulting in increased pulmonary eosinophilia and damaged lung tissue. "

Related Drugs and Biologics

1.	DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN)
2.	Mannose-Binding Lectin (Mannan-Binding Lectin)
3.	Galectins (Galectin)
4.	Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)
5.	Lectins
6.	Selectins
7.	Interleukin-13
8.	Interleukin-5 (Interleukin 5)
9.	Vaccines
10.	Adenosine Triphosphate (ATP)

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Ligation
3.	Immunotherapy
4.	Stem Cell Transplantation
5.	Hematopoietic Stem Cell Transplantation