HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Galectins (Galectin)

A class of animal lectins that bind specifically to beta-galactoside in a calcium-independent manner. Members of this class are distiguished from other lectins by the presence of a conserved carbohydrate recognition domain. The majority of proteins in this class bind to sugar molecules in a sulfhydryl-dependent manner and are often referred to as S-type lectins, however this property is not required for membership in this class.

Also Known As:

Galectin; S-Type Lectin; D-Galactoside-Binding Lectin; Galactose-Binding Lectin; S-Type Lectins; beta-D-Gal(1-3)D-GalNAc Specific Lectins; beta-D-Galactosyl-Specific Lectin; beta-Galactoside Binding Lectin; Binding Lectin, beta-Galactoside; D Galactoside Binding Lectin; Galactose Binding Lectin; Lectin, D-Galactoside-Binding; Lectin, Galactose-Binding; Lectin, S-Type; Lectin, beta-D-Galactosyl-Specific; Lectin, beta-Galactoside Binding; Lectins, S Type; S Type Lectin; S Type Lectins; beta D Galactosyl Specific Lectin; beta Galactoside Binding Lectin; Galaptins; Lectins, S-Type

Networked: 543 relevant articles (13 outcomes, 56 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gabius, Hans-Joachim: 37 articles (03/2015 - 01/2002)
2.	André, Sabine: 36 articles (03/2015 - 01/2002)
3.	Rabinovich, Gabriel A: 25 articles (10/2015 - 01/2005)
4.	Kaltner, Herbert: 23 articles (01/2013 - 01/2002)
5.	Kaltner, H: 19 articles (04/2012 - 04/2000)
6.	Liu, Fu-Tong: 17 articles (02/2014 - 03/2002)
7.	Kiss, Robert: 15 articles (09/2012 - 09/2002)
8.	Gabius, H J: 14 articles (06/2012 - 04/2000)
9.	André, S: 13 articles (01/2014 - 09/2000)
10.	Raz, Avraham: 12 articles (01/2015 - 05/2003)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2014 - "In this review we have also emphasized the potential use of galectin inhibitors or modulators in the treatment of cancer and how this novel treatment modality may affect patient outcomes in the future. " 09/01/2015 - "The present study aims at evaluating and clarifying the diagnostic and prognostic value of the expression of cancer-related galectins in relation to the clinicopathological characters of AML patients. " 01/01/2015 - "Study of galectins in tumor immunity: strategies and methods." 05/01/2014 - "The aim of the present study was to investigate the expression pattern of both these galectins in canine non-neoplastic mammary tissues and mammary tumors (CMT). " 01/01/2014 - "This review contains an overview of experimental and clinical studies dealing with biological roles of galectins in tissue repair and in its parallel - the tumor growth."
2.	Infection 10/01/2015 - "Taken together, these results suggest that galectin is important in the innate immune response of shrimp to pathogens infection. " 08/04/2015 - "We previously reported that CvGal1, a galectin expressed in phagocytic cells (hemocytes) of the eastern oyster (Crassostrea virginica), is hijacked by the parasite Perkinsus marinus to enter the host, where it causes systemic infection and death. " 05/01/2015 - "pneumoniae infections significantly alter the glycosylation patterns of the airway epithelial surface and modulate galectin expression. " 05/01/2015 - "Desialylation of airway epithelial cells during influenza virus infection enhances pneumococcal adhesion via galectin binding." 02/01/2015 - "Also, it is evidenced that galectin binding to the parasites promotes binding to the host cells and higher infection rates. "
3.	Adenocarcinoma 01/01/2014 - "Using human colon adenocarcinoma (SW620) cells genetically engineered for its up- and down-regulation (Rac1+ and Rac1- cells) along with wild-type and mock-transfected control cells, the questions are addressed whether the presence of adhesion/growth-regulatory galectins and distinct aspects of cell surface glycosylation are affected. " 08/01/2002 - "The trivalent galactoside-containing HPMA copolymers did not yield a notable glycoside cluster effect for the beta-galactoside-binding lectin expressed on human colon-adenocarcinoma cells. " 03/01/2010 - "Lessons learned from this model system allowed us to study the galectin distribution pattern of tumors: cells obtained from mice carrying mammary adenocarcinoma or lymphoma were probed with Glyc-PAA-fluo using flow cytometry. " 06/01/2008 - "A 35 kDa glycoprotein whose abundance was previously demonstrated to be enhanced in sera of patients with endometrial adenocarcinoma (n = 12), was isolated from pooled sera of three of the cancer patients using champedak galactose-binding lectin affinity chromatography in the present study. " 11/01/2001 - "Inhibitory effects of cell adhesion and liver metastasis of adenocarcinoma via portal vein by lectin-binding sugar and anti-galectin-3 antibody was examined to determine the role of galectin-laminin binding in cancer liver metastasis. "
4.	Carcinoma (Carcinomatosis) 01/01/2015 - "The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux." 02/01/2014 - "Among 15 positive clones isolated, two novel genes, galectin 9 and PINCH, were expressed at much higher levels in cancerous lesions than in normal tissues in all the patients with clear-cell carcinoma who were examined. " 11/01/2012 - "An emerging aspect of its functionality is the orchestrated modulation of N/O-glycosylation and galectin expression to induce anoikis in human Capan-1 pancreatic carcinoma cells. " 09/01/2012 - "Galectin labeling of cells from paraffinized tissues may serve as a diagnostic tool in the detection and classification of thyroid carcinomas." 11/01/2007 - "The results demonstrate a complex expression pattern of the galectin network in urothelial carcinomas. "
5.	Nephritis 11/01/2000 - "Efficacy of galectins in the amelioration of nephrotoxic serum nephritis in Wistar Kyoto rats." 04/01/2012 - "This is the first study that relates a galectin, an endogenous lectin family, to IgA nephritis and thus should stimulate new avenues of research into the pathophysiology of the disease." 09/01/2012 - "Sera from 14 women with metastatic breast cancer, 12 healthy controls, 14 patients with IgA-nephritis (IgAN), and 12 patients with other glomerulonephritis were fractionated by affinity chromatography on immobilized human galectin-1 or galectin-8N, and the protein amounts of the bound and unbound fractions for each galectin were determined. "

Related Drugs and Biologics

1.	Galectins (Galectin)
2.	Galectin 3 (LGALS3)
3.	Lectins
4.	3-nitrotyrosine
5.	Messenger RNA (mRNA)
6.	Antigens
7.	C-Type Lectins (C-Type Lectin)
8.	Selectins
9.	Proteins (Proteins, Gene)
10.	Carrier Proteins (Binding Protein)

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Immunomodulation
3.	Therapeutics
4.	Drug Therapy (Chemotherapy)
5.	Immunotherapy