Lectins

Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.

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Networked: 1537 relevant articles (25 outcomes, 167 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gabius, Hans-Joachim: 18 articles (07/2015 - 03/2002)
2.	André, Sabine: 17 articles (07/2015 - 03/2002)
3.	Schumacher, Udo: 12 articles (10/2015 - 02/2002)
4.	Kaltner, H: 9 articles (04/2012 - 04/2000)
5.	Gabius, H J: 8 articles (01/2005 - 01/2000)
6.	Cavada, Benildo Sousa: 7 articles (02/2015 - 11/2008)
7.	André, S: 7 articles (03/2008 - 09/2000)
8.	Samuelson, John: 6 articles (01/2015 - 05/2006)
9.	Gabius, H-J: 6 articles (04/2012 - 02/2002)
10.	Kaltner, Herbert: 6 articles (12/2010 - 12/2002)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2009 - "The use of lectins has been demonstrated to be effective in different activities including anti-inflammatory, antimicrobial, and in cancer therapy. " 01/01/2013 - "This article briefly summarizes the involvement of lectins in the metastatic process and also describes different approaches used to prevent these undesirable carbohydrate-lectin binding events, which should ultimately lead to improvement in current cancer therapies. " 08/01/2015 - "Studies have revealed that lectins have potential to act as an adjuvant chemotherapeutic agent in cancer of different origin. " 07/01/2014 - "To study proapoptotic properties of total phytohemagglutinine and its isolectins in human cell culture of not tumor origin 4BL we observed a change in the frequency of apoptotic cells in the tested cell culture under the influence of the total phytohemagglutinine and erythroagglutinin by the method of specific color luminescent dye. " 05/15/2012 - "The real-time lectin screening of a range of lectins, including Con A, DBA, PNA and UEA-I, enabled the accurate study of the glycosylation changes between cells, such as changes associated with cancer progression and development. "
2.	Infection 12/26/2013 - "Here, we examined efficacy of these lectins against infection with PR8 (H1N1) influenza A virus using mouse model studies and a human tracheal epithelial cell system. " 10/01/2006 - "Lectins play a critical role in host protection against infection. " 12/02/2013 - "Combinations of GNA with CV-N or MVL in HCV infection studies revealed synergistic inhibitory effects, which can be explained by different glycan recognition profiles of the mainly high-mannoside specific lectins, and supports the hypothesis that these lectins inhibit through different and complex modes of action. " 01/01/2013 - "The closely related viral K3 protein, is also able to target these lectins in exogenous expressions studies, but only weakly during viral infection. " 04/05/2006 - "In the present study we evaluated Canavalia brasiliensis (ConBr), Pisum arvense (PAA) and Artocarpus integrifolia (KM+) lectins as immunostimulatory molecules in vaccination against Leishmania amazonensis infection. "
3.	Carcinoma (Carcinomatosis) 06/01/2015 - "To study the effects of total phytohemagglutinin (PHA) and its isolectins on cell death and apoptosis in human HEp-2 carcinoma cells and to analyze the possible molecular mechanisms of lectin induced apoptosis. " 01/01/2005 - "Introduction of labeled endogenous lectins as a tool for the study of functional glycomics at the cellular level in head and neck squamous epithelia and carcinomas enables a complex interpretation of studied data because these lectins are normally occurring in these tissues. " 10/18/1999 - "The purpose of this study was to determine whether lectins can improve the lipofection efficiency in lung carcinoma cells. " 12/01/1990 - "[Studies on the location of eight lectins in breast carcinoma]." 07/01/1990 - "Eight lectins were used to study 100 cases of breast carcinoma and 56 cases of non-cancerous breast tissues by lectin histochemical method. "
4.	Neoplasm Metastasis (Metastasis) 10/01/2002 - "In vivo non-metastasizing cells are characterized by a lower content of surface lectins to tetrasaccharides SiaLex [Neu5Aca2-3Galb1-4(Fuca1-3) GlcNAcb] and SiaLea [Neu5Aca2-3Galb1-3(Fuca1-4)GlcNAcb] and trisaccharide HSO3Lex [HSO32-3Galb1-4(Fuca1-3)GlcNAcb] compared to cells forming metastases in the syngeneic system. " 11/01/1994 - "Histochemical aspects of the process of experimentally induced metastasis were examined by light and electron microscopy with labelled lectins employed as a probe. " 12/01/1990 - "No relationship between changes of the eight lectins and metastases in axillary lymph nodes was observed, but the authors considered that PNA-affinitive histochemistry was beneficial to the detection of micrometastases in lymph nodes." 06/20/1986 - "[Lectins and the organotropy of metastasis]." 11/15/1983 - "Liver lectins: mediators for metastases?"
5.	Adenoma (Adenomas) 01/01/1983 - "Lectins have been and will be very useful in the detection of different subtypes of adenomas in each specific group." 01/01/2000 - "The purpose of this study was to detect the above lectins binding sites and so examine alterations in glycoconjugate expression in neoplastic cells of 52 colorectal adenomas with various clinicopathologic characteristics and proliferation rates. " 01/01/1989 - "All the tested lectins were reactive in up to 90% of adenomas as well as in adjacent mucosa. " 06/01/1991 - "[A study of binding sites of lectins in colorectal adenomas and carcinomas: the optical and electron microscopical findings]." 10/01/2015 - "Binding patterns of all lectins except SNA-I, Con A and DBA changed during the adenoma-carcinoma sequence. "

Related Drugs and Biologics

1.	Antigens
2.	Galectins (Galectin)
3.	Glycoproteins (Glycoprotein)
4.	Horseradish Peroxidase
5.	Fluorescein (Funduscein)
6.	Concanavalin A
7.	Polysaccharides
8.	Galactose (Galactopyranose)
9.	Fucose
10.	Mannose-Binding Lectin (Mannan-Binding Lectin)

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Photochemotherapy (Photodynamic Therapy)
3.	Quantum Dots (Quantum Dot)
4.	Electroacupuncture
5.	Gastrectomy