HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Endometrial Stromal Tumors

Subscribe to New Research on Endometrial Stromal Tumors

Neoplasms of the endometrial stroma that sometimes involve the MYOMETRIUM. These tumors contain cells that may closely or remotely resemble the normal stromal cells. Endometrial stromal neoplasms are divided into three categories: (1) benign stromal nodules; (2) low-grade stromal sarcoma, or endolymphatic stromal myosis; and (3) malignant endometrial stromal sarcoma (SARCOMA, ENDOMETRIAL STROMAL).

Also Known As:

Endolymphatic Stromal Myosis; Sarcoma, Endometrial Stromal, Low-Grade; Endolymphatic Stromal Myoses; Endometrial Stromal Tumor; Myoses, Endolymphatic Stromal; Myosis, Endolymphatic Stromal; Stromal Myoses, Endolymphatic; Stromal Myosis, Endolymphatic; Stromal Tumor, Endometrial; Stromal Tumors, Endometrial; Tumor, Endometrial Stromal; Tumors, Endometrial Stromal

Networked: 30 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Smooth Muscle Tumor
2.	Neoplasms (Cancer)
3.	Endometrial Stromal Sarcoma
4.	Sarcoma (Soft Tissue Sarcoma)
5.	Leiomyosarcoma

Experts

1.	Oliva, Esther: 3 articles (03/2009 - 04/2002)
2.	Gutierrez-Pecharroman, Ana: 1 article (03/2014)
3.	Moratalla-Bartolomé, Enrique: 1 article (03/2014)
4.	Rubio-Marin, Dolores: 1 article (03/2014)
5.	Pascual, Alejandro: 1 article (03/2014)
6.	García-Cosío, Mónica: 1 article (03/2014)
7.	Palacios, José: 1 article (03/2014)
8.	Tirado-Zambrana, Pernilla: 1 article (03/2014)
9.	Ordi, Jaume: 1 article (01/2013)
10.	Vidal, August: 1 article (01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Endometrial Stromal Tumors:

1.	Calmodulin-Binding Proteins (Caldesmon)IBA 04/01/2005 - "Both the polypectomy and subsequent hysterectomy specimens revealed a predominant proliferation of CD10-negative, caldesmon-negative, and CD117-positive epithelioid cells set within a stroma containing vascular proliferation resembling endometrial stromal tumor. " 04/01/2002 - "h-caldesmon was positive in almost all nonepithelioid smooth muscle tumors and in areas of smooth muscle differentiation in endometrial stromal tumors; it was positive in only about half of the epithelioid smooth muscle tumors and negative in all UTROSCTs. " 04/01/2001 - "h-Caldesmon expression effectively distinguishes endometrial stromal tumors from uterine smooth muscle tumors." 04/01/2001 - "In five "highly cellular" leiomyomas, h-caldesmon expression was markedly decreased or absent in areas morphologically resembling endometrial stromal tumors, raising the possibility that these tumors may be mixed smooth muscle-endometrial stromal neoplasms. " 04/01/2002 - "As a result, a panel of CD10, h-caldesmon, and desmin should be used and will distinguish endometrial stromal tumors from highly cellular leiomyomas in most cases. "
2.	DesminIBA 04/01/2002 - "The major conclusions of this study are as follows: 1) Pure endometrial stromal tumors are usually desmin negative. " 04/01/2002 - "As a result, a panel of CD10, h-caldesmon, and desmin should be used and will distinguish endometrial stromal tumors from highly cellular leiomyomas in most cases. " 01/01/2006 - "The endometrial stromal tumor was severely infiltrated by histiocytes, and was positive for vimentin, CD10, PgR and negative for actin, desmin, ER and caldesmon. " 04/01/2002 - "The expression of desmin, h-caldesmon, calponin, CD10, CD34, CD99, inhibin, and keratin (AE1/3-Cam 5.2) was studied in 10 conventional leiomyomas, 9 highly cellular leiomyomas, 9 epithelioid smooth muscle tumors, 9 leiomyosarcomas, 10 endometrial stromal tumors (4 with smooth muscle metaplasia), and 7 uterine tumors resembling ovarian sex cord tumors (UTROSCTs). "
3.	Carrier Proteins (Binding Protein)IBA 04/01/2001 - "This study's goal was to determine whether h-caldesmon, a smooth muscle-specific isoform of a calcium, calmodulin, and actin binding protein, could effectively distinguish endometrial stromal tumors from uterine smooth muscle tumors. "
4.	Calmodulin (Calcium-Dependent Activator Protein)IBA 04/01/2001 - "This study's goal was to determine whether h-caldesmon, a smooth muscle-specific isoform of a calcium, calmodulin, and actin binding protein, could effectively distinguish endometrial stromal tumors from uterine smooth muscle tumors. "
5.	CalciumIBA 04/01/2001 - "This study's goal was to determine whether h-caldesmon, a smooth muscle-specific isoform of a calcium, calmodulin, and actin binding protein, could effectively distinguish endometrial stromal tumors from uterine smooth muscle tumors. "
6.	Keratins (Keratin)IBA 10/01/2008 - "These results show that CK19 is most commonly expressed cytokeratin in endometrial stromal tumors. " 07/01/2008 - "In summary, the immunophenotype of most MAs resembled that of endometrial stromal tumors (positive for ER, PR, WT1, and CD10, with variable expression of muscle markers, AR and cytokeratin). " 01/01/1991 - "Histologic and immunohistochemical analysis of nine endometrial stromal tumors: an unexpected high frequency of keratin protein positivity." 04/01/2002 - "The expression of desmin, h-caldesmon, calponin, CD10, CD34, CD99, inhibin, and keratin (AE1/3-Cam 5.2) was studied in 10 conventional leiomyomas, 9 highly cellular leiomyomas, 9 epithelioid smooth muscle tumors, 9 leiomyosarcomas, 10 endometrial stromal tumors (4 with smooth muscle metaplasia), and 7 uterine tumors resembling ovarian sex cord tumors (UTROSCTs). "
7.	Tamoxifen FDA LinkGeneric 02/01/1997 - "Endolymphatic stromal myosis associated with tamoxifen use." 03/01/2014 - "Here, we review the clinical, pathologic, and immunohistochemical features of uterine tumors resembling ovarian sex cord tumors and endometrial stromal tumors with a sex cord component associated with tamoxifen treatment. " 02/01/1997 - "A case of low-grade endometrial stromal sarcoma (endolymphatic stromal myosis) occurring in a patient who had received tamoxifen citrate for 3 years following surgical treatment for breast cancer is presented. " 12/01/1999 - "Mesenchymal tumors including malignant mixed mullerian tumors, endometrial stromal sarcomas, adenosarcomas, and leiomyosarcomas have been more recently described with tamoxifen use. "
8.	Inhibins (Inhibin)IBA 05/01/2004 - "Inhibin alpha immunostaining was identified in 46 (81%) of 57 gonadal stromal tumors, one (14%) of seven endometrial stromal tumors, and one (50%) of two primary ovarian carcinoid tumors. " 05/01/2004 - "Inhibin beta immunostaining was detected in 55 (96%) of 57 gonadal stromal tumors, two (29%) of seven endometrial stromal tumors, one (50%) of two dysgerminomas, and in all of two (100%) primary ovarian carcinoid tumors. " 06/01/1999 - "Thirty uterine mesenchymal neoplasms (five epithelioid or plexiform smooth muscle tumors, three endometrial stromal tumors, two mixed endometrial stromal and smooth muscle tumors, 10 ESTSCLE, five UTROSCT, and five miscellaneous stromal processes) and five epithelial neoplasms were evaluated for expression of CD99 (clone 12E7) and inhibin (clone R1) in formalin-fixed, paraffin-embedded tissue. " 04/01/2002 - "The expression of desmin, h-caldesmon, calponin, CD10, CD34, CD99, inhibin, and keratin (AE1/3-Cam 5.2) was studied in 10 conventional leiomyomas, 9 highly cellular leiomyomas, 9 epithelioid smooth muscle tumors, 9 leiomyosarcomas, 10 endometrial stromal tumors (4 with smooth muscle metaplasia), and 7 uterine tumors resembling ovarian sex cord tumors (UTROSCTs). "
9.	DNA (Deoxyribonucleic Acid)IBA 02/15/1970 - "Nuclear DNA content in endolymphatic stromal myosis." 03/01/1989 - "None of the patients with stromal nodules or endolymphatic stromal myosis had extrauterine disease at presentation or tumors displaying a mitotic rate greater than 10/10 hpf (high-power fields), nuclear pleomorphism, atypical mitotic figures, DNA aneuploidy, or a high proliferative index (greater than 10% S phase cells). " 06/01/2008 - "In addition, direct DNA sequencing of beta-catenin exon 3 was conducted in 15 endometrial stromal tumors. "
10.	calretininIBA 04/01/2008 - "Endometrial stromal tumors with sex cord-like elements, on the other hand, usually express only 1 sex cord marker, mostly calretinin. " 01/01/2006 - "Endometrial stromal tumors with sex cord-like elements were less frequently positive for markers of sex cord differentiation, with each case positive for one marker (calretinin, two cases; CD99, one case). " 03/01/2009 - "In the female genital tract, calretinin was initially reported in Wolffian remnants and related lesions and later used in the diagnosis of sex cord stromal tumors of the ovary, endometrial stromal tumors with sex cord-like differentiation, and uterine tumors resembling sex cord tumors of the ovary. "

Therapies and Procedures

1.	Hysterectomy 02/01/2005 - "We propose that the patient with endometrial stromal tumor with limited infiltration should be more carefully followed than the usual ESN for possible metastasis and that a hysterectomy with meticulous histological examination of the specimen be performed before a diagnosis of primary extrauterine ESS is made, even in a case showing a grossly or radiologically normal uterus." 02/01/1986 - "A 24-year-old woman underwent a supracervical hysterectomy with findings of an endolymphatic stromal myosis (ESM) with vascular invasion as a submucosal tumor of the uterine fundus. " 04/01/2005 - "Both the polypectomy and subsequent hysterectomy specimens revealed a predominant proliferation of CD10-negative, caldesmon-negative, and CD117-positive epithelioid cells set within a stroma containing vascular proliferation resembling endometrial stromal tumor. "
2.	Ovariectomy (Oophorectomy) 09/01/2012 - "However, in endometrial stromal tumors, given the hormonal reponsiveness of most tumors, salpingo-oophorectomy is generally recommended. "