Quassins

A group of degraded TRITERPENES which have lost ten carbons (8 from the side chain, C17, and one from C4) so have C20 skeletons which could be misinterpreted as DITERPENES. They especially occur in plants of the SIMAROUBACEAE family.

Also Known As:

Networked: 86 relevant articles (9 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lin, Zhi-Xiu: 4 articles (03/2022 - 01/2017)
2.	Xian, Yan-Fang: 2 articles (03/2022 - 01/2017)
3.	Chen, Jiannan: 2 articles (02/2021 - 01/2021)
4.	Su, Ziren: 2 articles (02/2021 - 01/2021)
5.	Wang, Tongtong: 2 articles (02/2021 - 01/2021)
6.	Xie, Youliang: 2 articles (02/2021 - 01/2021)
7.	Zeng, Huifang: 2 articles (02/2021 - 01/2021)
8.	Du, Yanming: 2 articles (12/2020 - 01/2020)
9.	Hwang, Nicky: 2 articles (12/2020 - 01/2020)
10.	Pei, Yonggang: 2 articles (12/2020 - 01/2020)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2021 - "A number of previous studies have demonstrated the anticancer potential of brucein D (BD), a quassinoid extracted from Brucea javanica, against the cancers of the pancreas, bone, and liver. " 04/01/2023 - "The anti-proliferative and induced apoptotic activities of Eurycoma longifolia quassinoids on cancer cell lines could be promising therapeutic targets on BPH. " 03/10/2022 - "Brucein D (BD), a naturally occurring quassinoid, has been reported to exert anti-tumor effect in several cancers including PDAC. " 07/01/2017 - "Quassinoids from the Root of Eurycoma longifolia and Their Antiproliferative Activity on Human Cancer Cell Lines." 09/28/2006 - "An advanced intermediate toward anti-cancer quassinoids has been synthesized using a quadruple diene-transmissive [4+2]-cycloaddition strategy. "
2.	Hematologic Neoplasms (Hematological Malignancy) 11/01/2002 - "Since these responses are facilitated at clinically achievable concentrations, quassinoids may be of value for the management of hematological malignancies." 01/01/2020 - "Quassinoid analogs with enhanced efficacy for treatment of hematologic malignancies target the PI3Kγ isoform." 01/01/2020 - "The quassinoid family member Brusatol shows specific inhibitory activity against hematologic malignancies. " 12/01/2020 - "Brusatol, a quassinoid natural product, is effective against multiple diseases including hematologic malignancies, as we reported recently by targeting the PI3Kγ isoform, but toxicity limits its further development. "
3.	Osteoporosis 06/21/2018 - "Quassinoid-rich EL extract was effective in reducing skeletal deteriorations in the androgen-deficient osteoporosis rat model." 01/01/2018 - "Effects of standardized quassinoid-rich Eurycoma longifolia extract in a rat model of osteoporosis due to testosterone deficiency: A densitometric, morphometric and biomechanical study." 06/21/2018 - "The Effects of Quassinoid-Rich Eurycoma longifolia Extract on Bone Turnover and Histomorphometry Indices in the Androgen-Deficient Osteoporosis Rat Model."
4.	Obesity 09/01/2019 - "javanica demonstrated lipolytic activity at nanomolar concentrations, which were an order of magnitude lower than those of the previously reported quassinoids, suggesting that they may be useful for the treatment of obesity."
5.	Common Cold 12/23/2022 - "Evaluating the in Vitro Efficacy of Quassinoids from Eurycoma longifolia and Eurycoma harmandiana against Common Cold Human Coronavirus OC43 and SARS-CoV-2 Using In-Cell Enzyme-Linked Immunosorbent Assay."

Related Drugs and Biologics

1.	brusatol
2.	Protein Isoforms (Isoforms)
3.	bruceine A
4.	Paclitaxel (Taxol)
5.	Vincristine (Oncovin)
6.	Podophyllotoxin (Condylox)
7.	Immunosorbents
8.	Enzymes
9.	Androgens
10.	eurycomanone

Related Therapies and Procedures

1.	Therapeutics