Ephrins

Signaling proteins that are ligands for the EPH FAMILY RECEPTORS. They are membrane-bound proteins that are attached to the CELL MEMBRANE either through a GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR or through a transmembrane domain. Many of the ephrins are considered important intercellular signaling molecules that control morphogenic changes during embryogenesis.

Also Known As:

Networked: 706 relevant articles (5 outcomes, 64 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pasquale, Elena B: 22 articles (01/2021 - 12/2002)
2.	Tognolini, Massimiliano: 19 articles (07/2022 - 03/2011)
3.	Lodola, Alessio: 16 articles (07/2022 - 03/2011)
4.	Giorgio, Carmine: 15 articles (05/2021 - 03/2011)
5.	Boyd, Andrew W: 13 articles (01/2017 - 03/2002)
6.	Chen, Jin: 13 articles (11/2016 - 02/2002)
7.	Theocharis, Stamatios: 11 articles (05/2022 - 08/2013)
8.	Barocelli, Elisabetta: 11 articles (05/2021 - 03/2011)
9.	Wang, Jiandong: 11 articles (06/2019 - 04/2009)
10.	Lackmann, Martin: 10 articles (12/2012 - 03/2002)

Related Diseases

1.	Neoplasms (Cancer) 08/05/2021 - "A multitude of studies have proven the association between the expression of members of the EPH/ephrin system and various clinicopathological parameters, including disease stage, tumor histologic grade, and patients' overall survival. " 01/01/2021 - "Functional studies revealed that miR-196b acted as an oncomiR by directly targeting a tumor suppressor, ephrin type-A receptor 7 (EPHA7). " 08/01/2020 - "Recent studies have revealed that ephrin receptor (EPH) is implicated in important signal transduction of cancer development and progression. " 04/16/2020 - "In conclusion this work paves the way for further studies with Eph-ephrin inhibitors in order to confirm the Eph antagonism as innovative pharmacological approach with preventive benefit in the intestinal tumor development." 03/01/2019 - "Especially in cancer, recent studies have demonstrated that most of Eph and ephrin are up- or down-regulated in various types of cancer, and have been implicated in tumor progression, tumor malignancy, and prognosis. "
2.	Inflammation (Inflammations) 05/24/2021 - "UniPR1331: Small Eph/Ephrin Antagonist Beneficial in Intestinal Inflammation by Interfering with Type-B Signaling." 11/01/2023 - "The Eph/ephrin system symphony of gut inflammation." 02/01/2016 - "Therefore, therapeutic targeting of Eph/ephrin interaction using inhibitors, such as EphA4-Fc, may be a novel method to prevent tissue injury in acute inflammation by influencing endothelial integrity and by controlling vascular leak." 11/01/2012 - "Eph/Ephrin signaling in injury and inflammation." 08/01/2012 - "  Previous research has suggested that Ephrin receptor A3 (EphA3) plays signaling roles in the processes of inflammation by regulating lymphocyte migration and proliferation. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 11/01/2011 - "Targeting FGFR, ephrins, Mer, MET, and PDGFR-α in non-small cell lung cancer." 05/06/2011 - "The ephrin and Eph signaling circuit has been reported as deregulated in a number of tumor types including nonsmall cell lung cancer (NSCLC). " 09/01/2023 - "In-silico and structure-based assessment to evaluate pathogenicity of missense mutations associated with non-small cell lung cancer identified in the Eph-ephrin class of proteins." 01/10/2013 - "Inhibition of Ephrin B3-mediated survival signaling contributes to increased cell death response of non-small cell lung carcinoma cells after combined treatment with ionizing radiation and PKC 412." 02/04/2014 - "Ephrin (Eph) receptor A1, A4, A5 and A7 expression in human non-small cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients' survival."
4.	Glioblastoma (Glioblastoma Multiforme) 02/20/2020 - "In this paper, a microbiome drug metabolism case is presented, involving a lipophilic small molecule, N-(3β-hydroxy-Δ5-cholen-24-oyl)-l-tryptophan, UniPR1331, active as antagonist of the Eph-ephrin system and effective in vivo in a murine orthotopic model of glioblastoma multiforme (GBM). " 03/13/2019 - "The Small Molecule Ephrin Receptor Inhibitor, GLPG1790, Reduces Renewal Capabilities of Cancer Stem Cells, Showing Anti-Tumour Efficacy on Preclinical Glioblastoma Models." 05/11/2018 - "UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice." 06/05/2020 - "Targeting Ephrin Receptor Tyrosine Kinase A2 with a Selective Aptamer for Glioblastoma Stem Cells." 09/01/2006 - "Immunohistochemistry revealed robust staining for phosphorylated ephrin-B and ephrin-B3 in invading glioblastoma cells. "
5.	Prostatic Neoplasms (Prostate Cancer) 10/13/2023 - "A Pharmacological Investigation of Eph-Ephrin Antagonism in Prostate Cancer: UniPR1331 Efficacy Evidence." 05/09/2022 - "The consequences of continuous reverse Ephrin signaling activation in fibroblasts on prostate cancer (PCa) is unknown. " 12/01/2021 - "Ephrin type-A receptor 10 (EPHA10) has been implicated as a potential target for breast and prostate cancer therapy. " 06/01/2020 - "Eph-ephrin is a novel pathway that is upregulated in prostate cancer and promotes the initiation and progression of cancer. " 10/13/2023 - "In order to improve the comprehension of the pharmacological targeting of Eph receptors in prostate cancer, in the present work, we investigated the efficacy of Eph antagonism both in vitro and in vivo, using UniPR1331, a small orally bioavailable Eph-ephrin interaction inhibitor. "

Related Drugs and Biologics

1.	Eph Family Receptors (Eph Receptors)
2.	Phosphotransferases (Kinase)
3.	tyrosine receptor (receptor, tyrosine)
4.	Ephrin-A1 (Ephrin A1)
5.	Immune Checkpoint Inhibitors
6.	Ligands
7.	EphA1 Receptor (Eph Receptor)
8.	Proteins (Proteins, Gene)
9.	Messenger RNA (mRNA)
10.	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)

Related Therapies and Procedures

1.	Therapeutics
2.	Electroacupuncture
3.	Punctures
4.	Intranasal Administration
5.	Lasers (Laser)