EphA7 Receptor

An eph family receptor found widely expressed in embryo tissues, including the NERVOUS SYSTEM. In the BRAIN high levels of EphA7 expression occurs in the anterior tectum, medulla, RHOMBENCEPHALON, and SUBCOMMISSURAL ORGAN. Several isoforms of the protein occur due to multiple alternative spicing of the EphA7 mRNA.

Also Known As:

Receptor, EphA7; Cek11 Kinase; EphA7 Protein; Receptor Tyrosine Kinase Cek11

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Wang, Jiandong: 3 articles (01/2022 - 11/2007)
2.	Guan, Ming: 2 articles (10/2017 - 01/2009)
3.	Jung, Minsun: 1 article (02/2022)
4.	Lee, Seokhyeon: 1 article (02/2022)
5.	Moon, Kyung Chul: 1 article (02/2022)
6.	Feng, Xiao: 1 article (01/2022)
7.	He, Yan: 1 article (01/2022)
8.	Liu, Jie: 1 article (01/2022)
9.	Lv, Kang: 1 article (01/2022)
10.	Yu, Na: 1 article (01/2022)

Related Diseases

1.	Carcinoma (Carcinomatosis) 01/01/2009 - "Immunostaining analysis showed EphA7 protein was absent in 10 of 30 (33.3%) carcinoma samples available and 8 of them (80.0%) exhibited hypermethylation. " 11/01/2007 - "Differential expression of EphA7 receptor tyrosine kinase in gastric carcinoma."
2.	Skin Diseases (Skin Disease) 01/01/2022 - "EphA7 protein was positively expressed in normal basal cells, benign skin diseases, and compound nevus cells, but lost in areas of BCC tissues. "
3.	Prostatic Neoplasms (Prostate Cancer) 10/12/2017 - "To test the role of EphA7 receptor in prostate cancer (PCa) progression directly, we generated EphA7 receptor variants that were either lacking the cytoplasmic domain or carrying a point mutation that inhibits its phosphorylation by site-directed mutagenesis. "
4.	Pain (Aches) 02/01/2013 - "On the basis of EphA7 receptor expression in inflammatory cells, the developing mouse dental pulp, and trigeminal nerve system, EphA7 may possibly be involved in local inflammatory response and sensory innervation of adult dental pulp as well as odontogenic pain conducted through the trigeminal system. "
5.	Nevus (Nevi) 01/01/2022 - "EphA7 protein was positively expressed in normal basal cells, benign skin diseases, and compound nevus cells, but lost in areas of BCC tissues. "

Related Drugs and Biologics

1.	GPI-Linked Proteins
2.	Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)
3.	Tyrosine (L-Tyrosine)
4.	Protein-Tyrosine Kinases (Tyrosine Kinase)
5.	Phosphotransferases (Kinase)