EphA1 Receptor (Eph Receptor)

The founding member of the EPH FAMILY RECEPTORS. It was first cloned from an erythropoietin-producing human hepatocellular carcinoma cell line and is highly conserved among many mammalian species. Overproduction of the EphA1 receptor is associated with tumors and tumor cells of epithelial origin. It is also expressed at high levels in LIVER; LUNG; and KIDNEY; which is in contrast to many other members of the Eph receptor that are found primarily in tissues of the nervous system.

Also Known As:

Networked: 220 relevant articles (2 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pasquale, Elena B: 15 articles (01/2021 - 12/2002)
2.	Wang, Jiandong: 9 articles (01/2018 - 11/2007)
3.	Chen, Jin: 9 articles (11/2016 - 02/2002)
4.	Nagano, Kazuya: 7 articles (01/2018 - 01/2011)
5.	Tsutsumi, Yasuo: 5 articles (01/2018 - 01/2011)
6.	Pietzsch, Jens: 4 articles (01/2020 - 03/2012)
7.	Higashisaka, Kazuma: 4 articles (01/2018 - 12/2013)
8.	Kamada, Haruhiko: 4 articles (01/2015 - 01/2011)
9.	Mukai, Yohei: 4 articles (01/2015 - 01/2011)
10.	Yoshioka, Yasuo: 4 articles (01/2015 - 01/2011)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 07/01/2011 - "A paradigm shift in EPH receptor interaction: biological relevance of EPHB6 interaction with EPHA2 and EPHB2 in breast carcinoma cell lines." 11/22/2010 - "The identification of three novel candidates as EPH receptor genes might indicate a link between perturbed compartmentalization of early neoplastic lesions and breast cancer risk and progression. " 05/01/2007 - "This review focuses on EphB4, an Eph receptor that has both tumor-suppressing and tumor-promoting activities in breast cancer. " 01/01/2021 - "Therefore, the consensus genes of the major signaling pathways were further analyzed, revealing that among patients with TP53 wild-type breast cancer, the prognosis of patients with low expression levels of fibroblast growth factor receptor 1, LIM homeobox 2 and EPH receptor B2 was improved compared with that of patients with high expression levels, while among patients with TP53-mutant breast cancer, there was no significant difference in survival status. " 08/01/2013 - "In this study, we demonstrate Eph receptor B4 (EphB4), a member of Eph kinase family, a positive regulator of ER-α in human breast cancer cell lines (MCF-7, T-47D and BT-474). "
2.	Pain (Aches) 08/01/2023 - "We critically analyse the present status of Eph receptor system and conclude that extrapolating the pharmacological and genetic approaches using a strong therapeutic development framework could serve as next-generation analgesics for the management of chronic pain." 01/01/2019 - "The study aims to investigate the analgesic effects of microRNA-129-5p (miR-129-5p) on bone cancer pain (BCP) by targeting Eph receptor B1 (EphB1) through the EphB1/EphrinB2 signaling pathway. " 09/30/2008 - "Bidirectional signaling between ephrins and Eph receptor tyrosine kinases was first found to play important roles during development, but recently has been implicated in synaptic plasticity and pain processing in the matured nervous system. "
3.	Neoplasms (Cancer) 10/31/2023 - "In cancer cells, there was evidence of bilateral Eph receptor signaling with both tumor-suppressing and tumor-promoting actions. " 01/01/2023 - "The Functions of EphA1 Receptor Tyrosine Kinase in Several Tumors." 01/01/2023 - "There is increasing evidence that points to the dysregulation of EPH receptor B6 (EPHB6) in various cancers. " 10/01/2022 - "It has been reported that Eph receptor A7 (EphA7) was a potential target of miR-944 which is transcriptionally activated in cancer. " 01/01/2022 - "Experimental evidence revealed Eph receptor bidirectional signaling with both tumor-promoting and tumor-suppressing activities in different cancer types and surrounding environment. "
4.	Hepatocellular Carcinoma (Hepatoma) 01/01/2022 - "Eph receptor B2 (EPHB2) regulates cancer stem cell-like properties in hepatocellular carcinoma." 03/01/2013 - "In this study, the expression of metadherin (MTDH) and erythropoietin-producing hepatoma-amplified sequence (Eph) receptor A7 (EphA7) in 96 benign and 108 malignant lesions of gallbladder was determined by immunohistochemistry, and their correlations with pathological features and prognosis were analyzed. " 01/01/2020 - "Inactivation or deletion of erythropoietin-producing hepatoma (EPH) receptor A2 (EphA2) attenuated BBB damage and promoted tight junction formation. " 02/01/2010 - "EphA1 receptor silencing by small interfering RNA has antiangiogenic and antitumor efficacy in hepatocellular carcinoma." 12/20/2022 - "PTPRJ regulates mouse optic nerve projection by inhibiting the phosphorylation of the erythropoietin-producing hepatocellular carcinoma (Eph) receptor and abelson murine leukemia viral oncogene homolog 1 (c-Abl). "
5.	Inflammation (Inflammations) 10/01/2016 - "Eph receptor B4 (EPHB4) also involved in endothelial activation in inflammation. " 01/01/2008 - "Since it has been reported that the ephrin/Eph receptor system plays important signaling roles in inflammation processes, we attempted to examine ephrinB molecules in T cells and synovial cells derived from RA in this study. " 07/01/2006 - "Putative dual role of ephrin-Eph receptor interactions in inflammation." 01/01/2014 - "Abnormal Eph receptor and ephrin signaling is implicated in a variety of epithelial diseases raising the intriguing possibility that this cell-cell communication pathway can be therapeutically harnessed to normalize epithelial function in pathological settings like cancer or chronic inflammation. " 07/01/2019 - "Eph receptor tyrosine kinases have a wide range of biological functions and have gradually been recognized increasingly as key regulators of inflammation and injury diseases. "

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	Type 1 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 1)
3.	Ligands
4.	Ephrins
5.	Phosphotransferases (Kinase)
6.	Erythropoietin
7.	MicroRNAs (MicroRNA)
8.	Tyrosine (L-Tyrosine)
9.	tyrosine receptor (receptor, tyrosine)
10.	Ephrin-A5 (AL-1)

Related Therapies and Procedures

1.	Chemoradiotherapy
2.	Lenses
3.	Therapeutics
4.	Immunotherapy
5.	Precision Medicine