Iron Regulatory Protein 2

A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its rate of degradation is increased in the presence of IRON.

Also Known As:

Networked: 46 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Rouault, Tracey A: 6 articles (04/2022 - 05/2003)
2.	Ghosh, Manik C: 4 articles (02/2016 - 08/2005)
3.	Chen, Xinbin: 3 articles (01/2020 - 01/2017)
4.	Zhang, Jin: 3 articles (01/2020 - 01/2017)
5.	Zhang, Yanhong: 3 articles (01/2020 - 01/2017)
6.	Deng, Zhiyong: 3 articles (10/2017 - 01/2014)
7.	Torti, Frank M: 3 articles (10/2017 - 01/2014)
8.	Torti, Suzy V: 3 articles (10/2017 - 01/2014)
9.	Meyron-Holtz, Esther G: 3 articles (10/2012 - 08/2005)
10.	Jiang, Hong: 2 articles (04/2022 - 01/2019)

Related Diseases

1.	Neoplasms (Cancer) 03/25/2016 - "In this study, we identified a 24-h rhythm in iron regulatory protein 2 (IRP2) levels in colon-26 tumors implanted in mice. " 01/01/2020 - "Iron regulatory protein 2 (IRP2) is a key regulator of iron homeostasis and is found to be altered in several types of human cancer. " 01/05/2023 - "KLF14 exerts its anti-tumor function by inhibiting Iron-responsive element-binding protein 2 (IRP2), which then causes transferrin receptor-1(TfR1) downregulation and ferritin upregulation on the basis of IRP-IREs system. " 01/01/2021 - "Incubation of ferroptosis inhibitors ferrostatin-1 (Fer-1) or knockdown of iron-responsive element-binding protein 2 (IREB2) notably weakened curcumin-induced anti-tumor effect and ferroptosis in A549 and H1299 cells. " 01/01/2017 - "Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2."
2.	Iron Deficiencies 02/01/2005 - "Iron-regulatory protein 2 (IRP2), a posttranscriptional regulator of iron metabolism, undergoes proteasomal degradation in iron-replete cells, while it is stabilized in iron deficiency or hypoxia. " 01/01/2019 - "Cisplatin causes intracellular iron deficiency through direct inhibition of the master regulator of iron metabolism, iron regulatory protein 2 (IRP2) with marginal effects on IRP1. " 01/01/2017 - "In this study, to develop a novel molecular-targeted therapy against TFR1 to modulate iron metabolism, we initially determined the expression pattern of several iron-related genes along with TFR1 and found that ATLL cells presented characteristic of an iron-deficiency state such as high expression of iron-regulatory protein 2 (IRP2) and low expression of its E3 ubiquitin-ligase, FBXL5. "
3.	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 01/01/2017 - "In this study, to develop a novel molecular-targeted therapy against TFR1 to modulate iron metabolism, we initially determined the expression pattern of several iron-related genes along with TFR1 and found that ATLL cells presented characteristic of an iron-deficiency state such as high expression of iron-regulatory protein 2 (IRP2) and low expression of its E3 ubiquitin-ligase, FBXL5. "
4.	Leukemia 08/01/2022 - "In this study, we found that multidrug-resistant (MDR) K562/adriamycin (ADM) leukemia cells possessed higher glutathione (GSH) levels and iron-regulatory protein 2 (IRP2), transferrin receptor, ferritin heavy chain 1 (FTH1), and peroxidase-4 (GPX4) expression than parental drug-sensitive K562 leukemia cells. "
5.	Chronic Obstructive Pulmonary Disease (COPD) 01/01/2020 - "Background: Iron responsive element binding protein 2 (IREB2) variants may be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). " 01/18/2016 - "It is reported that the iron-responsive element-binding protein 2 (IREB2) gene rs2568494 polymorphism might be associated with COPD risk. " 11/26/2012 - "Genome-wide association studies and integrative genomics approaches have demonstrated significant associations between chronic obstructive pulmonary disease (COPD) and single-nucleotide polymorphisms (SNPs) in the chromosome 15q25 region that includes iron-responsive element binding protein 2 gene (IREB2) and CHRNA3/5 in non-Asian populations. " 10/01/2009 - "IREB2 protein and mRNA were increased in lung-tissue samples from COPD subjects in comparison to controls. " 01/01/2015 - "Recently, variants in the hypoxia-inducible factor 1α (HIF1A), cholinergic receptor, neuronal nicotinic, alpha polypeptide-5, and iron-responsive element-binding protein 2 gene (IREB2) genes were found to be associated with COPD. "

Related Drugs and Biologics

1.	Iron
2.	Transferrin Receptors (Transferrin Receptor)
3.	Apoferritins
4.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
5.	Glutathione (Reduced Glutathione)
6.	Doxorubicin (Adriamycin)
7.	Proteins (Proteins, Gene)
8.	Messenger RNA (mRNA)
9.	Heme Oxygenase-1
10.	Iron Regulatory Protein 2

Related Therapies and Procedures

1.	Molecular Targeted Therapy