Hepatitis delta Antigens (HDAg)

03/01/1990 - "Antibody directed to HDAg is important in the diagnosis of HDV infection, and it is likely but not yet proven that the immune response to HDAg provides significant protection against subsequent exposures to HDV. "
01/01/2012 - "Genetic studies of HDV have shown that delta antigen protein is responsible for replication of genome and play a foremost role in viral infection. "
03/01/2014 - "The presence of HDAg-positive human hepatocytes determined after 2, 3, and 6 weeks of HDV inoculation demonstrated establishment and maintenance of intrahepatic HDV mono-infection. "
08/01/2012 - "To collect the clinical data and sera samples of HBV infected patients and to detect HDAg, Anti-HDV as well as HBV infection markers by means of enzyme-linked immunosorbnent assay. "
03/01/2012 - "In the setting of HBV/HDV simultaneous infection, a majority of human hepatocytes stained HDAg-positive long before HBV spreading was completed, confirming that HDV can replicate intrahepatically also in the absence of HBV infection. "

04/01/1985 - "[Immunohistological study of delta antigen in the liver with fulminant hepatitis]."
10/01/1994 - "Also, another isolate (SZ 92) obtained from a chronic severe hepatitis patient in Sichuan was cloned with HDAg-coding region. "
07/01/1989 - "Type D hepatitis was diagnosed by RIA for anti-delta in serum and by PAP stain for delta antigen in hepatocytes. "
01/23/1989 - "[Delta antigen in viral hepatitis--current state of research]."
01/01/1988 - "12 of the delta infected patients with fulminant hepatitis were positive for total antibody to the delta antigen, and 2 were delta antigen positive. "

01/01/1991 - "One patient, who cleared HDAg has complete biochemical remission of his liver disease with 2 years of follow-up. "
02/01/1994 - "No biological or histopathological evidence of liver disease was detectable during 18 months of observation, suggesting that neither the large nor small form of HDAg is directly cytopathic to the hepatocyte in vivo."
03/01/1992 - "It was found that the intrahepatic HDAg detection rate was related to the pathologic type of the liver disease. "
01/01/1990 - "A relationship of intrahepatic HDAg to the pathologic type of the liver disease was observed. "
02/01/1988 - "Intrahepatic expression of delta antigen, histologic activity and outcome of liver disease."

04/01/2001 - "The distribution and the expression of bax, HDAg and hepatocyte apoptosis are significantly correlated with the activity of inflammation and the severity of the liver damage. "
02/01/1988 - "The highest degree of inflammation and intrahepatic expression of HDAg was found before the elimination of the virus, while the outcome of HDV disease was unrelated to the severity of the initial morphologic lesion. "
02/01/1988 - "A significant positive relation was observed between the number of HDAg-positive cells and the extent of portal inflammation (Spearman's rank coefficient 0.75). "
02/01/1986 - "A second episode of hepatitis occurred on Day 145, and severe necrosis and inflammation recurred along with the reappearance of delta antigen in the hepatocytes. "
01/01/1991 - "Patients with no liver HDAg expression after treatment (n = 5) showed improved AST levels (normal in 4) and diminished liver cell inflammation. "

08/01/2004 - "Recently, innate immune lymphocytes, such as natural killer (NK) T cells and gamma/delta antigen receptor-bearing T (gamma delta T) cells, have garnered much attention, and their biological significance in the tumor immunity, allergic diseases and infectious diseases is extensively exploited. "
10/12/2001 - "We observed protection against syngeneic tumor formation and growth in mice immunized with DNA plasmids encoding secreted or intracellular forms of HDAg and LHDAg but not with recombinant HDAg establishing the generation of significant cellular immunity in vivo. "