Hepatitis delta Antigens (HDAg)

Antigens produced by various strains of HEPATITIS D VIRUS.

Also Known As:

HDAg; Hepatitis D Antigen; Antigen, Hepatitis D; Antigen, Hepatitis delta; Antigen, delta; Antigens, Hepatitis D; Antigens, Hepatitis delta; delta Antigen, Hepatitis; delta Antigens, Hepatitis; Hepatitis D Antigens; Hepatitis delta Antigen; delta Antigen

Networked: 250 relevant articles (10 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wu, Jaw-Ching: 3 articles (05/2020 - 03/2005)
2.	Allweiss, Lena: 3 articles (01/2019 - 03/2012)
3.	Dandri, Maura: 3 articles (01/2019 - 03/2012)
4.	Lohse, Ansgar W: 3 articles (01/2019 - 03/2012)
5.	Lütgehetmann, Marc: 3 articles (01/2019 - 03/2012)
6.	Volz, Tassilo: 3 articles (01/2019 - 03/2012)
7.	Wedemeyer, Heiner: 3 articles (09/2014 - 01/2011)
8.	Roggendorf, M: 3 articles (10/2001 - 01/2001)
9.	Li, Q: 3 articles (07/2001 - 02/2001)
10.	Wang, Y: 3 articles (07/2001 - 02/2001)

Related Diseases

1.	Infections 03/01/1990 - "Antibody directed to HDAg is important in the diagnosis of HDV infection, and it is likely but not yet proven that the immune response to HDAg provides significant protection against subsequent exposures to HDV. " 01/01/2022 - "Interestingly, these viral particles were less infectious, probably due to an enrichment in edited genomes that are packaged, leading to unproductive infection given the absence of S-HDAg synthesis after viral entry. " 01/01/2019 - "Notably, HDAg-positive cells appeared in clusters, indicating that HDV was transmitted to daughter cells during liver regeneration even in the absence of de novo infection. " 01/01/2018 - "The identification of conserved regions in HDAg poses the basis for designing innovative targets against HDV-infection." 12/01/2017 - "Furthermore, we devloped a chemiluminescent immunoassay (HDV-CLEIA) to quantitatively determine intracellular HDAg with a dynamic range of 5-11,000 pg/mL. HDV-CLEIA can be used as an alternative approach to assess HDV infection. "
2.	Hepatitis 10/01/1995 - "[Pathological characteristics and localization of delta antigen in type D hepatitis]." 10/01/1994 - "Also, another isolate (SZ 92) obtained from a chronic severe hepatitis patient in Sichuan was cloned with HDAg-coding region. " 01/23/1989 - "[Delta antigen in viral hepatitis--current state of research]." 02/01/1986 - "Delta antigen persisted in the liver following the second episode of hepatitis and has remained positive throughout the observation period of 1 year. " 10/01/1985 - "The histological pattern of delta antigen-positive acute hepatitis was characterized by the presence of a large number of intralobular apoptotic bodies. "
3.	Superinfection 01/01/1993 - "The effects of using recombinant vaccinia viruses expressing either large or small HDAg to protect woodchuck hepadnavirus carriers from HDV superinfection." 09/01/1992 - "To investigate the prevalence and clinical features of hepatitis delta virus (HDV) superinfection in hepatitis B virus (HBV) carriers, antibody to hepatitis delta antigen (anti-HD) was determined in the sera of 328 HBV carriers in Japan. " 02/01/1986 - "The results indicate that a superinfection with the DV produced a biphasic ALT response concomitant with the appearance of the delta antigen in biopsy materials. " 07/01/1985 - "Delta antigen is currently thought to reflect superinfection of the liver with a defective RNA virus (delta agent), requiring helper function from hepatitis B virus for its replication. " 11/01/1993 - "Partial control of hepatitis delta virus superinfection by immunisation of woodchucks (Marmota monax) with hepatitis delta antigen expressed by a recombinant vaccinia or baculovirus."
4.	Liver Diseases (Liver Disease) 01/01/1991 - "One patient, who cleared HDAg has complete biochemical remission of his liver disease with 2 years of follow-up. " 02/01/1994 - "No biological or histopathological evidence of liver disease was detectable during 18 months of observation, suggesting that neither the large nor small form of HDAg is directly cytopathic to the hepatocyte in vivo." 03/01/1992 - "It was found that the intrahepatic HDAg detection rate was related to the pathologic type of the liver disease. " 01/01/1990 - "A relationship of intrahepatic HDAg to the pathologic type of the liver disease was observed. " 02/01/1988 - "Intrahepatic expression of delta antigen, histologic activity and outcome of liver disease."
5.	Inflammation (Inflammations) 10/01/2023 - "A significant negative correlation was found between HDAg intensity and focal lymphocytic inflammation and in patients with both anti-SSA/Ro-52 and anti-SSA/Ro-60. " 01/01/2021 - "We have also found that lack of L-HDAg resulted in the increase of S-HDAg expression levels and the exacerbation of liver damage, which was associated with an increment in liver inflammation but did not require T cells. " 04/01/2001 - "The distribution and the expression of bax, HDAg and hepatocyte apoptosis are significantly correlated with the activity of inflammation and the severity of the liver damage. " 02/01/1988 - "The highest degree of inflammation and intrahepatic expression of HDAg was found before the elimination of the virus, while the outcome of HDV disease was unrelated to the severity of the initial morphologic lesion. " 02/01/1988 - "A significant positive relation was observed between the number of HDAg-positive cells and the extent of portal inflammation (Spearman's rank coefficient 0.75). "

Related Drugs and Biologics

1.	Hepatitis B Surface Antigens (HBsAg)
2.	Antigens
3.	Immunoglobulin M (IgM)
4.	DNA (Deoxyribonucleic Acid)
5.	Peptides (Polypeptides)
6.	hepatitis delta virus large antigen
7.	2,4-dinitrofluorobenzene sulfonic acid
8.	Vaccines
9.	Indicators and Reagents (Reagents)
10.	Dinitrobenzenes

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Liver Transplantation
3.	Therapeutics
4.	Intraperitoneal Injections