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Transcription Factor TFIIIA

Subscribe to New Research on Transcription Factor TFIIIA

One of several general transcription factors that are specific for RNA POLYMERASE III. It is a zinc finger (ZINC FINGERS) protein and is required for transcription of 5S ribosomal genes.

Also Known As:

5S Gene-Specific Transcription Factor; 5S RNA Gene Transcription Factor; GTF3A Protein; TFIIIA; Transcription Factor IIIA; 5S Gene Specific Transcription Factor

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Transcription Factors: 20597
    - General Transcription Factors: 13
      - TFIII Transcription Factors
        Transcription Factor TFIIIA: 8
        human OPTN protein
  - DNA-Binding Proteins: 1111
    - General Transcription Factors: 13
      - TFIII Transcription Factors
        Transcription Factor TFIIIA: 8
        human OPTN protein

Experts

1.	Madhusudhan, Kunapuli T: 1 article (01/2002)
2.	Hocker, James R: 1 article (01/2002)
3.	Lerner, Megan R: 1 article (01/2002)
4.	Hanas, Rushie J: 1 article (01/2002)
5.	Cheng, Yong-Gang: 1 article (01/2002)
6.	Lightfoot, Stan A: 1 article (01/2002)
7.	Hanas, Jay S: 1 article (01/2002)
8.	Brackett, Daniel J: 1 article (01/2002)
9.	Moreland, Rodney J: 1 article (01/2002)
10.	Dyson, H J: 1 article (01/2000)

Related Diseases

1.	Decompression Sickness (Bends) 08/10/1989 - "Using both circular permutation and circularization assays we provide convincing biochemical evidence that TFIIIA bends the DNA at the internal promoter of the 5S gene." 01/01/1989 - "Electron microscopy reveals that transcription factor TFIIIA bends 5S DNA." 12/20/1992 - "Although our data do not allow us directly to link the two bends, our results suggest that TFIIIA could form a folded structure by stabilizing the same bent conformation that is induced by binding of Zn2+. The chemistry of Zn2+ binding to DNA, and the sequence around the bend center, suggest that the bend is most probably caused by joint co-ordination of Zn2+ to the N-7 groups of stacked purine residues."
2.	Neoplasms (Cancer) 01/09/2002 - "A monoclonal antibody against human p53 tumor suppressor bound to rat and mouse TFIIIA but not to human TFIIIA in Western blots. " 04/05/1999 - "The homologous proteins are: KH domain-containing protein overexpressed in cancer (Koc); zipcode binding protein, a protein which binds to a conserved nucleotide element in chicken beta-actin mRNA (ZBP1); and a protein which binds to a promoter cis element in Xenopus laevis TFIIIA gene (B3). "
3.	Wilms Tumor (Wilm's Tumor) 01/28/2000 - "Capping at the C terminus of the alpha-helix in each zinc finger, incorporating a consensus TGEKP linker sequence that follows each finger, provides substantial binding energy to the DNA complexes of zinc fingers 1-3 of TFIIIA (zf1-3) and the four zinc fingers of the Wilms' tumor suppressor protein (wt1-4). "
4.	Infection 11/01/1987 - "Among four distinct components required for accurate transcription in vitro from cloned DNA templates, activities of RNA polymerase III and transcription factor TFIIIA were not significantly affected by virus infection. "
5.	Glioblastoma (Glioblastoma Multiforme) 06/01/1990 - "Sequence analysis indicates that the protein encoded by the ciD transcript contains a domain of five tandem amino acid repeats that have sequence similarity to the zinc-finger repeats of the Xenopus transcription factor TFIIIA and that share the highest degree of identity with the human zinc-finger protein GLI, which has been found to be amplified in several human glioblastomas."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Staphylococcal Protein A (A, Protein)
3.	Messenger RNA (mRNA)
4.	RNA Polymerase III
5.	Proteins (Proteins, Gene)
6.	Carrier Proteins (Binding Protein)
7.	Carbon Monoxide
8.	Actins (F Actin)
9.	purine