Lamins

01/01/2014 - "Here I have reviewed those studies relating to altered expression of lamins in cancers and argue that consideration of changes in the expression of individual lamins cannot be considered in isolation but only in the context of an understanding of their functions in transformed cells. "
01/01/2014 - " lamins are targets for degradation in the apoptotic process, and accordingly are often used as markers for apoptosis, intriguing studies on an active role of lamins in the initiation or the prevention of apoptosis have been published recently and give rise to a renewed interest in the role of lamins in cancer. "
10/15/2006 - "Recently, several studies allowed to establish a functional link between DNA repair and A-type lamins-associated syndromes, evidencing a relation between these syndromes, physiological aging and cancer. "
01/01/2014 - "Because of their involvement in supporting nuclear architecture, it has been postulated that the basis for nuclear shape changes during cancer progression is altered expression of nuclear lamins and in particular lamins A and C. "
01/01/2014 - "We also speculate on the involvement of lamins in tumor cell proliferation through the control of ROS metabolism. "

10/01/1988 - "Antibodies to nuclear lamins occurred in 12 of 16 cases of active lupoid hepatitis, but not in 35 patients with the disease in remission. "
01/01/1989 - "Antibodies to nuclear lamins were found in 75 per cent of the active lupoid hepatitis cases, but not in patients with inactive disease. "

02/01/2011 - "Autosomal dominant Emery-Dreifuss muscular dystrophy is caused by mutations in LMNA gene encoding lamins A and C. "
09/01/2010 - "In humans, mutations in A-type lamins give rise to diseases that exhibit tissue-specific defects, such as Emery-Dreifuss muscular dystrophy. "
05/01/2008 - "Autosomal dominant Emery-Dreifuss muscular dystrophy (EDMD) is characterized by muscle wasting and is caused by mutations in the LMNA gene encoding A-type lamins. "
09/01/2005 - "Mutations in the LMNA gene, which encodes nuclear lamins A and C by alternative splicing, can give rise to Emery-Dreifuss muscular dystrophy. "
09/01/2005 - "Lamins A and C are differentially dysfunctional in autosomal dominant Emery-Dreifuss muscular dystrophy."

11/01/2011 - "Moreover, our studies revealed novel pathways that contribute to genomic instability and that can be activated in disease states independent of the status of A-type lamins."
09/01/2015 - "However, ATM signalling and DNA repair remained intact after lamins A/C depletion, whereas nesprin-2 disruption ablated downstream Chk2 activation and induced genomic instability. "
08/01/2011 - "Although a correlation exists between alterations in lamins and genomic instability, the molecular mechanisms remain largely unknown. "
07/01/2010 - "In addition, we discuss the evidence for a mechanism in which defects in lamins result in genomic instability and senescence."
03/01/2010 - "These findings have shed some light onto the putative molecular mechanisms by which alterations in A-type lamins induce genomic instability and contribute to disease."

02/01/2012 - "Mutations in A-type nuclear lamins gene, LMNA, lead to a dilated cardiomyopathy. "
07/01/2010 - "Mutations in LMNA, which encodes A-type nuclear lamins, cause disorders of striated muscle that have as a common feature dilated cardiomyopathy. "
02/01/2010 - "Mutations in the LMNA gene, encoding lamins A/C, represent a significant cause of dilated cardiomyopathy. "
10/03/2014 - "Mutations in the LMNA gene encoding A-type nuclear lamins can cause dilated cardiomyopathy with or without skeletal muscular dystrophy. "
04/01/2014 - "Mutations in lamins, which are ubiquitous nuclear intermediate filaments, lead to a variety of disorders including muscular dystrophy and dilated cardiomyopathy. "