RNA-Binding Protein EWS

A ubiquitous hnRNP protein that contains an RNA RECOGNITION MOTIF and C-terminal ranBP2-type zinc finger. It localizes to the CELL NUCLEUS and CYTOPLASM and is expressed as different isoforms in various tissues, interacting with CALMODULIN and TUMOR SUPPRESSOR PROTEIN P53 to negatively regulate cell growth. Translocations that result in the formation of fusion proteins containing parts of RNA-binding protein EWS are associated with EWING SARCOMA.

Also Known As:

Networked: 61 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Gehring, Heinz: 7 articles (01/2011 - 08/2003)
2.	Pahlich, Steffen: 5 articles (01/2011 - 10/2005)
3.	Azuma, Mizuki: 4 articles (01/2021 - 10/2007)
4.	Lee, Junghee: 3 articles (01/2019 - 01/2015)
5.	Ryu, Hoon: 3 articles (01/2019 - 01/2015)
6.	Leemann-Zakaryan, Ruzanna P: 3 articles (01/2011 - 02/2009)
7.	Park, Hyewon: 2 articles (01/2021 - 01/2014)
8.	Kowall, Neil W: 2 articles (01/2019 - 01/2015)
9.	Lee, Sean Bong: 2 articles (01/2019 - 01/2015)
10.	Stegmaier, Kimberly: 2 articles (01/2018 - 12/2014)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2014 - "We further found a striking relocalization of the EWSR1 protein from nucleus to cytoplasm in MMR-deficient cancers and that the nonprotein-coding MSI target locus itself has a modulatory effect on EWSR1 gene expression through alternative 3' end processing of the EWSR1 gene. " 12/15/1993 - "In these tumors the carboxyl terminal region of Fli-1 was found to be fused with the amino terminal region of a putative RNA binding protein, EWS. " 07/01/2011 - "Ewing family tumors are characterized by a translocation between the RNA binding protein EWS and one of five ETS transcription factors, most commonly FLI1. " 10/01/2016 - "EWS RNA-binding protein 1 gene (EWSR1) rearrangement is found in 45% of cutaneous, soft tissue and bone myoepithelial neoplasms, and pleomorphic adenoma gene 1 (PLAG1) aberrations are found in 37% of EWSR1-negative soft tissue myoepitheliomas. " 01/01/2015 - "Ewing's Sarcoma Oncogene (ews) on chromosome 22q12 is encoding a ubiquitously expressed RNA-binding protein (EWS) with unknown function that is target of tumor-specific chromosomal translocations in Ewing's sarcoma family of tumors. "
2.	Leukemia 07/01/2023 - "The purpose of this study was therefore to report a case of primary intracranial ES, whose molecular features included both EWSR1-FLI1 (EWS RNA binding protein 1- Friend leukemia integration 1) gene fusion and EWSR1 gene mutation. " 12/01/2021 - ": AFP, Alpha-fetoprotein; CCL14, C-C motif chemokine ligand 14; CK19, Cytokeratin 19; CI, coefficient interval; COL1A1, Collagen 1A1; DFS, Disease-free Survival; EWSR1, Ewing Sarcoma breakpoint region 1/EWS RNA binding protein 1; FLI1, Friend leukemia virus integration 1; GEO, Gene Expression Omnibus; GO, Gene Ontology; HCC, Hepatocellular carcinoma; HR, Hazard ratio; KEGG, Kyoto Encyclopedia of Genes and Genomes; mRNA, messenger Ribonucleic Acid; N, nodule; OS, Overall survival; PPI, Protein-Protein Interaction analysis; RNA, Ribonucleic Acid; SD, Standard Deviation; TCGA, The Cancer Genome Atlas; T, tumor; TNM, tumor-nodule-metastasis."
3.	Prostatic Neoplasms (Prostate Cancer) 01/01/2020 - "This is the first study aimed at targeting the ERG-EWS protein-protein interaction for the development of a small molecule-based prostate cancer therapy."
4.	Ewing Sarcoma (Sarcoma, Ewing) 01/01/2019 - "EWSR1 (Ewing Sarcoma breakpoint region 1/EWS RNA binding protein 1) gene is ubiquitously expressed in most cell types, indicating it has diverse roles in various cellular processes and organ development. " 07/01/2015 - "A 6-year-old boy initially presented to an outside hospital with a right orbital mass with biopsy positive for translocation involving EWS RNA-binding protein 1 gene and imaging consistent with primary extraskeletal Ewing sarcoma (ES). " 07/01/2012 - "Given these commonalities, we hypothesized that a related protein, EWSR1 (Ewing sarcoma breakpoint region 1), might also exhibit similar properties and therefore could contribute to disease. " 12/25/2009 - "The Ewing Sarcoma (EWS) protein is a ubiquitously expressed RNA processing factor that localises predominantly to the nucleus. " 05/15/2009 - "Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines."
5.	Genetic Translocation (Chromosomal Translocation) 10/03/2017 - "A chimeric fusion between the RNA binding protein EWS and the ETS family transcription factor FLI1 (EWS-FLI1), which is generated from a chromosomal translocation, is implicated in driving most ES cases by modulation of transcription and alternative splicing. " 01/01/2015 - "Ewing's Sarcoma Oncogene (ews) on chromosome 22q12 is encoding a ubiquitously expressed RNA-binding protein (EWS) with unknown function that is target of tumor-specific chromosomal translocations in Ewing's sarcoma family of tumors. " 12/01/2014 - "Chromosomal translocation that results in fusion of the genes encoding RNA-binding protein EWS and transcription factor FLI1 (EWS-FLI1) is pathognomonic for Ewing sarcoma. " 05/01/2014 - "Extraskeletal myxoid chondrosarcoma is characterized by the reciprocal chromosomal translocation t(9;22) and the resultant fused gene EWS RNA-binding protein 1 and nuclear receptor subfamily 4, group A, member 3 (EWSR1-NR4A3). " 11/15/2006 - "Although much is known about the oncogenic functions of chimeric Ewing sarcoma (EWS) fusion proteins that result from chromosomal translocations, the cellular role of the normal EWS protein is not well characterized. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	DNA (Deoxyribonucleic Acid)
3.	Oncogene Proteins (Oncogene Protein)
4.	EWS-FLI fusion protein
5.	Transcription Factors (Transcription Factor)
6.	RNA (Ribonucleic Acid)
7.	RNA-Binding Proteins (RNA-Binding Protein)
8.	Proto-Oncogene Proteins c-ets
9.	DNA-Binding Proteins (DNA Binding Protein)
10.	Arginine (L-Arginine)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy