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Systemic Mastocytosis

A group of disorders caused by the abnormal proliferation of MAST CELLS in a variety of extracutaneous tissues including bone marrow, liver, spleen, lymph nodes, and gastrointestinal tract. Systemic mastocytosis is commonly seen in adults. These diseases are categorized on the basis of clinical features, pathologic findings, and prognosis.
Also Known As:
Mastocytosis, Systemic; Aggressive Systemic Mastocytosis; Indolent Systemic Mastocytosis; Aggressive Systemic Mastocytoses; Indolent Systemic Mastocytoses; Mast-Cell Disease, Systemic; Mast-Cell Diseases, Systemic; Mastocytoses, Aggressive Systemic; Mastocytoses, Indolent Systemic; Mastocytoses, Systemic; Mastocytosis, Aggressive Systemic; Mastocytosis, Indolent Systemic; Systemic Mast Cell Disease; Systemic Mast-Cell Diseases; Systemic Mastocytoses; Systemic Mastocytoses, Aggressive; Systemic Mastocytoses, Indolent; Systemic Mastocytosis, Aggressive; Systemic Mastocytosis, Indolent; Systemic Mast-Cell Disease
Networked: 774 relevant articles (57 outcomes, 57 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Anaphylaxis (Anaphylactic Shock)
2. Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
3. Neoplasms (Cancer)
4. Systemic Mastocytosis
5. Mastocytosis

Experts

1. Valent, Peter: 59 articles (01/2022 - 01/2002)
2. Akin, Cem: 35 articles (01/2022 - 07/2002)
3. Reiter, Andreas: 29 articles (11/2022 - 08/2011)
4. Horny, Hans-Peter: 29 articles (01/2022 - 01/2002)
5. Gotlib, Jason: 27 articles (11/2022 - 10/2005)
6. Sperr, Wolfgang R: 26 articles (01/2022 - 01/2002)
7. Metcalfe, Dean D: 24 articles (01/2022 - 07/2002)
8. Tefferi, Ayalew: 22 articles (01/2022 - 11/2002)
9. Sotlar, Karl: 21 articles (01/2022 - 01/2005)
10. Verstovsek, Srdan: 20 articles (12/2021 - 10/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Systemic Mastocytosis:
1. Imatinib Mesylate (Gleevec)FDA Link
2. avapritinibIBA
3. CladribineFDA LinkGeneric
4. midostaurinIBA
5. Tyrosine Kinase InhibitorsIBA
6. Omalizumab (Xolair)FDA Link
7. Interferon-alpha (Interferon Alfa)IBA
8. Cromolyn Sodium (Cromoglicic Acid)FDA LinkGeneric
9. Dasatinib (BMS 354825)FDA Link
10. Monoclonal AntibodiesIBA

Therapies and Procedures

1. Therapeutics
2. Immunotherapy
3. Drug Therapy (Chemotherapy)
4. Phototherapy (Light Therapy)
5. Splenectomy