Heterogeneous-Nuclear Ribonucleoprotein K

A heterogeneous-nuclear ribonucleoprotein found in the CELL NUCLEUS and the CYTOPLASM. Heterogeneous-nuclear ribonucleoprotein K has been implicated in the regulation of gene expression at nearly all levels: GENETIC TRANSCRIPTION; mRNA processing (RNA PROCESSING, POST-TRANSCRIPTIONAL), mRNA transport, mRNA stability, and translation (TRANSLATION, GENETIC). The hnRNP protein has a strong affinity for polypyrimidine-rich RNA and for single-stranded polypyrimidine-rich DNA. Multiple hnRNP K protein isoforms exist due to alternative splicing and display different nucleic-acid-binding properties.

Also Known As:

Networked: 149 relevant articles (1 outcomes, 30 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wadhwa, Renu: 8 articles (01/2020 - 05/2007)
2.	Kaul, Sunil C: 7 articles (01/2020 - 05/2013)
3.	Barboro, Paola: 6 articles (06/2018 - 06/2009)
4.	Ferrari, Nicoletta: 6 articles (06/2018 - 06/2009)
5.	Gao, Ran: 5 articles (01/2022 - 05/2013)
6.	Balbi, Cecilia: 5 articles (10/2014 - 06/2009)
7.	Zong, Sa: 4 articles (06/2022 - 01/2016)
8.	Gallardo, Miguel: 4 articles (01/2021 - 10/2015)
9.	Post, Sean M: 4 articles (01/2021 - 10/2015)
10.	Zhang, Xiaorui: 4 articles (01/2021 - 10/2015)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 05/19/2009 - "Heterogeneous nuclear ribonucleoprotein K: altered pattern of expression associated with diagnosis and prognosis of prostate cancer." 05/01/2014 - "Prostate cancer: prognostic significance of the association of heterogeneous nuclear ribonucleoprotein K and androgen receptor expression." 03/15/2009 - "We show here that hnRNP-K is a novel inhibitor of AR mRNA translation that regulates androgen-responsive gene expression and prostate cancer cell proliferation. " 03/04/2004 - "The combination of upregulated activity in the growth-promoting PI3K/Akt pathway, suppression of Nmi and overexpression of hnRNP-K and c-myc proteins may explain why the prostate cancer cells were found to be more resistant to the growth inhibitory effects of INFgamma." 06/15/2009 - "Novel antivascular efficacy of metronomic docetaxel therapy in prostate cancer: hnRNP K as a player."
2.	Neoplasms (Cancer) 11/25/2023 - "Based on an Hnrnpk haploinsufficient mouse model, a recent study demonstrated a function of hnRNP K in pathogenesis of myeloid malignancies via the regulation of cellular proliferation and myeloid differentiation programs. " 01/01/2019 - "However, related studies demonstrated that hnRNP K acts as a tumor suppressor to suppress tumor formation. " 01/01/2019 - "Numerous studies indicated hnRNP K is aberrantly elevated in multiple tumors. " 06/01/2016 - "Numerous studies also show that abnormal expression of hnRNP K is closely associated with the tumor formation. " 10/01/2014 - "Herein, we provide a brief overview of the multifunctional roles of hnRNP K and discuss clinical studies that have demonstrated its involvement in cancer development and progression."
3.	Infections 12/10/2018 - "To study the differences in demographic characteristics, related factors, hnRNP K protein and HPV16 infection among NC, CINⅠand CINⅡ/Ⅲgroups, χ(2) test, trend χ(2) test, and Kruskal-Wallis H test were conducted. " 09/01/2013 - "Further studies showed that hnRNP K suppresses apoptosis of virus-infected cells, resulting in increased cell survival during VSV infection. " 12/03/2020 - "Finally, we find an increase in hnRNP K in nuclear speckles upon IAV infection, which may alter accessibility of hnRNP K for host transcripts thereby leading to a program of host splicing changes that promote IAV replication." 12/10/2018 - "There might be interaction between hnRNP K protein overexpression and HPV16 infection existed on the progress of CINⅡ/Ⅲ. " 12/10/2018 - "Two-way interactions between hnRNP K protein and HPV16 infection on CIN were analyzed by using additive model and related indicators. "
4.	Colorectal Neoplasms (Colorectal Cancer) 03/06/2020 - "LINC01413/hnRNP-K/ZEB1 Axis Accelerates Cell Proliferation and EMT in Colorectal Cancer via Inducing YAP1/TAZ1 Translocation." 01/01/2017 - "Here, we investigate its role in radioresistance of colorectal carcinoma (CRC) and evaluate a pharmacological approach to enhance CRC radiosensitivity via downregulation of hnRNP K. " 09/01/2012 - "Expression of HSP27 and hnRNP K were investigated by immunohistochemistry (IHC) in a series of tissue microarrays containing 175 primary colorectal cancers and their corresponding normal mucosa samples and matched with clinicopathological features and patient survival. " 10/09/2006 - "Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer." 05/01/2010 - "HnRNP K and PDI marked response to chemotherapy to human colorectal cancer cells."
5.	Lung Neoplasms (Lung Cancer) 04/20/2008 - "The aim of this study is to determine hnRNP K expression in lung cancer tissues and normal lung tissues and to provide data for the diagnosis and treatment of lung cancer. " 01/01/2022 - "Heterogeneous nuclear ribonucleoprotein K promotes the progression of lung cancer by inhibiting the p53-dependent signaling pathway." 09/06/2019 - "The interaction of MAP 1B/LC1 with hnRNP K may improve our understanding on the mechanism of TGF-β1-induced EMT in lung cancer." 09/06/2019 - "hnRNP K can promote the EMT process of lung cancer cells induced by TGF-β1 through interacting with MAP 1B-LC1. " 09/06/2019 - "Interaction of hnRNP K with MAP 1B-LC1 promotes TGF-β1-mediated epithelial to mesenchymal transition in lung cancer cells."

Related Drugs and Biologics

1.	Docetaxel (Taxotere)
2.	Heterogeneous-Nuclear Ribonucleoprotein K
3.	Proteins (Proteins, Gene)
4.	Matrix Metalloproteinases (MMPs)
5.	Antiviral Agents (Antivirals)
6.	RNA (Ribonucleic Acid)
7.	Small Interfering RNA (siRNA)
8.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
9.	Biomarkers (Surrogate Marker)
10.	Androgen Receptors (Androgen Receptor)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Surgical Instruments (Clip)
4.	Radiotherapy