Heterogeneous-Nuclear Ribonucleoprotein Group C (HNRNP C Protein)

A group of closely related heterogeneous-nuclear ribonucleoproteins of approximately 41-43 kDa in size found in the cell nucleus. Members of this class have been implicated in a variety of processes including splicing, polyadenylation, and nuclear retention of RNA.

Also Known As:

HNRNP C Protein; C-Type Protein HnRNP; Heterogeneous-Nuclear Ribonucleoprotein C; Heterogeneous-Nuclear Ribonucleoprotein Type C1-C2; hnRNP C Proteins; hnRNP C1-C2 Proteins; Heterogeneous Nuclear Ribonucleoprotein C; Heterogeneous Nuclear Ribonucleoprotein Group C; Heterogeneous Nuclear Ribonucleoprotein Type C1 C2; Ribonucleoprotein C, Heterogeneous-Nuclear; hnRNP C1 C2 Proteins

Networked: 15 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - RNA-Binding Proteins: 3262
      - Ribonucleoproteins: 1286
        Heterogeneous-Nuclear Ribonucleoproteins: 446
        Heterogeneous-Nuclear Ribonucleoprotein Group C: 15
        C1 HNRNP: 1
        human HNRNPC protein
        human RALY protein
        mouse Hnrnpc protein
        mouse Raly protein
      - RNA Recognition Motif Proteins
        Heterogeneous-Nuclear Ribonucleoproteins: 446
        Heterogeneous-Nuclear Ribonucleoprotein Group C: 15
        C1 HNRNP: 1
        human HNRNPC protein
        human RALY protein
        mouse Hnrnpc protein
        mouse Raly protein
  - Nucleoproteins: 1870
    - RNA-Binding Proteins: 3262
      - Ribonucleoproteins: 1286
        Heterogeneous-Nuclear Ribonucleoproteins: 446
        Heterogeneous-Nuclear Ribonucleoprotein Group C: 15
        C1 HNRNP: 1
        human HNRNPC protein
        human RALY protein
        mouse Hnrnpc protein
        mouse Raly protein
      - RNA Recognition Motif Proteins
        Heterogeneous-Nuclear Ribonucleoproteins: 446
        Heterogeneous-Nuclear Ribonucleoprotein Group C: 15
        C1 HNRNP: 1
        human HNRNPC protein
        human RALY protein
        mouse Hnrnpc protein
        mouse Raly protein

Experts

1.	Chen, Yingjie: 1 article (01/2022)
2.	Feng, Nianjie: 1 article (01/2022)
3.	Guan, Quan-Lin: 1 article (01/2022)
4.	Hu, Chen-Xiao: 1 article (01/2022)
5.	Hu, WeiBin: 1 article (01/2022)
6.	Li, Jing: 1 article (01/2022)
7.	Liu, Lin: 1 article (01/2022)
8.	Liu, Xiaoyu: 1 article (01/2022)
9.	Lu, Jian: 1 article (01/2022)
10.	Pan, Chenxi: 1 article (01/2022)

Related Diseases

1.	Adenocarcinoma of Lung 01/01/2020 - "Elevated Heterogeneous Nuclear Ribonucleoprotein C Expression Correlates With Poor Prognosis in Patients With Surgically Resected Lung Adenocarcinoma." 01/01/2022 - "Oncogenic Role of Heterogeneous Nuclear Ribonucleoprotein C in Multiple Cancer Types, with a Particular Focus on Lung Adenocarcinoma, Using a Pan-Cancer Analysis and Cell Line Experiments." 02/27/2016 - "Indeed, an m(6)A site in the lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) was recently shown to induce a local change in structure that increases the accessibility of a U5-tract for recognition and binding by heterogeneous nuclear ribonucleoprotein C (HNRNPC). " 01/01/2021 - "In the present study, five m6A regulatory factors have been revealed, namely heterogeneous nuclear ribonucleoprotein A2/B1(HNRNPA2B1), heterogeneous nuclear ribonucleoprotein C (HNRNPC), Vir like m6A methyltransferase associated protein (KIAA1429/VIRMA), RNA binding motif protein 15 (RBM15) and methyltransferase like 3 (METTL3), which are closely related to the overall survival (OS) of patients with lung adenocarcinoma (LUAD). " 01/01/2022 - "Four genes (writer: methyltransferase like 3 [METTL3] and three readers: insulin like growth factor 2 mRNA binding protein 2 [IGF2BP2], heterogeneous nuclear ribonucleoprotein C [HNRNPC], and heterogeneous nuclear ribonucleoprotein A2/B1 [HNRNPA2B1]) were selected to construct a survival risk prediction model and the results of immunohistochemical staining showed that the expression of these four m6A genes was significantly different between lung adenocarcinoma tissues and normal lung tissues (p < .01). "
2.	Neoplasms (Cancer) 01/01/2022 - "A systematic pan-cancer study demonstrates the oncogenic function of heterogeneous nuclear ribonucleoprotein C." 01/01/2022 - "Although some evidence has validated the connection between heterogeneous nuclear ribonucleoprotein C (HNRNPC) and the progression of tumors, a pan-cancer investigation is still required. " 01/01/2022 - "Although complex links between heterogeneous nuclear ribonucleoprotein C (HNRNPC) and numerous types of cancer have been shown in both cell and animal models, a comprehensive pan-cancer investigation on the features and activities of HNRNPC is still lacking. " 01/01/2022 - "Oncogenic Role of Heterogeneous Nuclear Ribonucleoprotein C in Multiple Cancer Types, with a Particular Focus on Lung Adenocarcinoma, Using a Pan-Cancer Analysis and Cell Line Experiments." 01/01/2021 - "Accumulating evidence shows that heterogeneous nuclear ribonucleoprotein C (HNRNPC), which is mainly involved in RNA splicing, export, and translation, promotes progression and metastasis of multiple tumor types; however, the effects of HNRNPC in HCC are unknown. "
3.	Adenocarcinoma 01/01/2022 - "In this study, we found that heterogeneous nuclear ribonucleoprotein C (hnRNPC), a RBP, is highly expressed in pancreatic ductal adenocarcinoma (PDAC) tissues and cells. "
4.	Squamous Cell Carcinoma of Head and Neck 08/01/2022 - "This study aimed to examine a novel method for prognostic evaluation of patients with oral squamous cell carcinoma (OSCC) based on the expression of heterogeneous nuclear ribonucleoprotein C (HNRNPC), YTH domain-binding protein 2 (YTHDF2), and methyltransferase 14 (METTL14). "
5.	Neoplasm Metastasis (Metastasis) 01/01/2021 - "Accumulating evidence shows that heterogeneous nuclear ribonucleoprotein C (HNRNPC), which is mainly involved in RNA splicing, export, and translation, promotes progression and metastasis of multiple tumor types; however, the effects of HNRNPC in HCC are unknown. " 10/10/2021 - "Here, we demonstrated that an m6A regulator, heterogeneous nuclear ribonucleoprotein C (HNRNPC), modulated alternative splicing events to promote PDAC metastasis. " 02/27/2016 - "Indeed, an m(6)A site in the lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) was recently shown to induce a local change in structure that increases the accessibility of a U5-tract for recognition and binding by heterogeneous nuclear ribonucleoprotein C (HNRNPC). "

Related Drugs and Biologics

1.	Methyltransferases
2.	6-methyladenine
3.	Heterogeneous-Nuclear Ribonucleoprotein Group A-B
4.	Proteins (Proteins, Gene)
5.	Carrier Proteins (Binding Protein)
6.	Messenger RNA (mRNA)
7.	Long Noncoding RNA
8.	Heterogeneous-Nuclear Ribonucleoprotein L
9.	RNA-Binding Proteins (RNA-Binding Protein)
10.	Urokinase-Type Plasminogen Activator (Urokinase)