Heterogeneous-Nuclear Ribonucleoproteins (Informatin)

A family of ribonucleoproteins that were originally found as proteins bound to nascent RNA transcripts in the form of ribonucleoprotein particles. Although considered ribonucleoproteins they are primarily classified by their protein component. They are involved in a variety of processes such as packaging of RNA and RNA TRANSPORT within the nucleus. A subset of heterogeneous-nuclear ribonucleoproteins are involved in additional functions such as nucleocytoplasmic transport (ACTIVE TRANSPORT, CELL NUCLEUS) of RNA and mRNA stability in the CYTOPLASM.

Also Known As:

Networked: 446 relevant articles (4 outcomes, 51 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Howe, Philip H: 8 articles (01/2022 - 07/2011)
2.	Sueoka, Eisaburo: 8 articles (11/2008 - 06/2002)
3.	Steiner, Günter: 7 articles (01/2021 - 07/2002)
4.	Skriner, Karl: 6 articles (01/2021 - 07/2002)
5.	Sueoka, Naoko: 6 articles (11/2006 - 06/2002)
6.	Howley, Breege V: 5 articles (01/2022 - 01/2016)
7.	Lashley, Tammaryn: 5 articles (02/2021 - 10/2016)
8.	Carrier, France: 5 articles (01/2021 - 01/2006)
9.	Taylor, J Paul: 5 articles (01/2021 - 03/2013)
10.	Chan, John S D: 5 articles (10/2019 - 10/2012)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2016 - "In this study we found that UPF1 regulates the expression of genes with functions in inflammation and myeloid cell differentiation via hnRNP E2. " 01/01/2022 - "By a functional screening for hnRNPs members in LPS-stimulated macrophage inflammatory response, we identified hnRNP UL1 as a negative regulator of NF-κB-mediated inflammation. " 01/01/2019 - "We identified a broad spectrum of novel potential miR-328/hnRNP E2 and miR-328 targets involved in regulation of compartment specific cellular processes, such as inflammation or RNA splicing. " 11/30/2022 - "In light of the rising interest in the intersection between cancer and inflammation, this review will focus on recent knowledge of the biological roles of hnRNP A2B1 in cancer, immune response, and inflammation." 11/30/2022 - "Given its regulatory role in inflammation and cancer progression, hnRNP A2B1 has become a novel player in immune response, inflammation, and cancer development. "
2.	Infections 12/01/2022 - "Both MERS-CoV and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection increased the total and phosphorylated forms of hnRNP C to activate the downstream CRK-mTOR pathway. " 01/01/2019 - "Strand-specific affinity of host factor hnRNP C1/C2 guides positive to negative-strand ratio in Coxsackievirus B3 infection." 05/10/2010 - "Infection of HeLa cells with poliovirus causes hnRNP C to re-localize from the nucleus, where it is normally retained during interphase, to the cytoplasm. " 01/01/2018 - "Correlating with disrupted hnRNP-vRNA binding, SINV growth kinetics were reduced relative to wild-type parental viral infections in vertebrate and invertebrate tissue culture models of infection. " 02/06/2015 - "In the present study, we investigated the role of hnRNP C1/C2 in DENV replication by using an in vitro model of DENV infection in a hepatocyte cell line (Huh7) and siRNA-mediated knockdown of hnRNP C1/C2. "
3.	Autoimmune Diseases (Autoimmune Disease) 06/01/2018 - "However, the functional role of hnRNP C1/C2 in autoimmune diseases is still not clearly understood. " 11/01/2023 - "Undervalued and novel roles of heterogeneous nuclear ribonucleoproteins in autoimmune diseases: Resurgence as potential biomarkers and targets." 08/01/1999 - "[Autoantibodies to the heterogeneous nuclear ribonucleoproteins and the autoimmune diseases]." 12/01/1996 - "Therefore, anti-hnRNP-A/B autoantibodies are not only valuable diagnostic markers but may also allow additional insights into the pathogenetic mechanisms of rheumatic autoimmune diseases." 01/01/1996 - "Therefore, anti-RA33/hnRNP-A/B autoantibodies are not only valuable diagnostic markers but may also allow additional insights into the pathogenesis of rheumatic autoimmune diseases."
4.	Starvation 01/01/2012 - "While the size of salivary glands, hnRNP levels in larval tissues, and thermotolerance of larvae/adult flies improved significantly following feeding either of the two formulations, the median life span and starvation resistance improved only with AR. " 09/01/2013 - "Starvation caused an increase in the expression of heterogeneous nuclear ribonucleoprotein (hnRNP) K protein and this increase coincided with the increase in the binding of hnRNP K to the regulatory element and a decrease in the expression of G6PD mRNA. "
5.	Neoplasms (Cancer) 01/01/2021 - "Based on The Cancer Genome Atlas database and the previous studies, we selected heterogeneous nuclear ribonucleoprotein (HNRNPD) as the research candidate and sought its downstream targeted genes. " 02/04/2011 - "Thus, this is the first study identifying altered function of hnRNP H1/H2 in tumor cells as a novel determinant of aberrant TP splicing thereby resulting in acquired chemoresistance to TP-activated fluoropyrimidine anticancer drugs." 08/08/2008 - "These studies indicate that hnRNP G promotes the expression of Txnip and mediates its tumor-suppressive effect." 03/01/2007 - "The present study thus implicates downregulation of hnRNP E2 as a novel mechanism to enhance the resistance of cancer cells to apoptosis." 05/15/2006 - "The current study was designed to test the hypothesis that hnRNP G is a tumor suppressor. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Autoantibodies
3.	Peptides (Polypeptides)
4.	Small Interfering RNA (siRNA)
5.	Cytokines
6.	Messenger RNA (mRNA)
7.	Heterogeneous-Nuclear Ribonucleoproteins (Informatin)
8.	hnRNP A2
9.	RNA (Ribonucleic Acid)
10.	Ribonucleoproteins

Related Therapies and Procedures

1.	Therapeutics
2.	Castration
3.	Surgical Instruments (Clip)
4.	Radiotherapy
5.	Lasers (Laser)