Aristolochic Acids

Nitro-phenanthrenes occurring in ARISTOLOCHIACEAE and other plants. They derive from stephanine (APORPHINES) by oxidative ring cleavage. The nitro group is a reactive alkylator (ALKYLATING AGENTS) that binds to biological macromolecules. Ingestion by humans is associated with nephropathy (NEPHRITIS). There is no relationship to the similar named aristolochene (SESQUITERPENES).

Networked: 79 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chan, Wan: 13 articles (01/2022 - 01/2016)
2.	Chan, Chi-Kong: 11 articles (01/2021 - 07/2016)
3.	Pavlović, Nikola M: 10 articles (04/2020 - 04/2013)
4.	Antoine, Marie-Hélène: 6 articles (10/2022 - 05/2015)
5.	Nortier, Joëlle: 6 articles (10/2022 - 03/2002)
6.	Grollman, Arthur P: 6 articles (01/2021 - 07/2007)
7.	Husson, Cécile: 5 articles (10/2022 - 05/2015)
8.	Nortier, Joëlle L: 5 articles (01/2022 - 02/2002)
9.	Liu, Yushuo: 4 articles (03/2019 - 10/2018)
10.	Li, Weiwei: 4 articles (10/2018 - 01/2016)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2015 - "Ingestion of aristolochic acids (AAs) contained in herbal remedies results in a renal disease and, frequently, urothelial malignancy. " 12/01/2011 - "Ingestion of aristolochic acids (AA) contained in herbal remedies results in a renal disease and, frequently, urothelial malignancy. " 11/01/2021 - "Aristolochic acids are known for nephrotoxicity, and implicated in multiple cancer types such as hepatocellular carcinomas demonstrated by recent studies. " 11/01/2017 - "After a discussion of the studies on the toxicity of aristolochic acids, experts attending the meeting discovered several problems, including the unclearness of exposure history, tumor-producing dose and latent period, the absence of some key factors such as hepatitis B, the small sample size, miscellaneous factors, incomplete evidence chains, the missing of analyses between data with huge differences, the insufficiency of fundamental research arguments, etc. In order to understand the toxicity of aristolochic acids and the carcinogenic risks, as well as guide clinical safe medication, the experts suggested that：①Complete the systematical evaluation of aristolochic acids carcinogenicity as soon as possible. " 02/10/2023 - "Long-term dietary exposure of aristolochic acids (AAs)-contaminated food proved to be one of the main culprits of Endemic Nephropathy, renal failure; and urothelial cancer. "
2.	Chronic Renal Insufficiency 01/01/2021 - "Emerging evidence suggests that chronic exposure to aristolochic acids (AAs) is one of the etiological pathways leading to chronic kidney disease (CKD). " 03/19/2019 - "Aristolochic Acids: Newly Identified Exposure Pathways of this Class of Environmental and Food-Borne Contaminants and its Potential Link to Chronic Kidney Diseases." 12/01/2015 - "Aristolochic acids (AA) are nephrotoxic and profibrotic agents, leading to chronic kidney disease. " 01/13/2016 - "Emerging evidence has suggested aristolochic acids (AAs) are linked to the development of Balkan endemic nephropathy (BEN), a chronic renal disease affecting numerous farmers living in the Balkan peninsula. " 01/01/2016 - "Aristolochic acids (AA) are implicated in the development of chronic renal disease and upper urinary tract carcinoma in humans. "
3.	Poisoning 06/01/2013 - "Studies conducted over the past decade have provided particularly strong arguments that BEN and UUC are caused by chronic poisoning with aristolochic acids (AAs). " 01/01/2014 - "To date several hypotheses have presented some findings that could be relevant to the etiology of BEN, but only one of them, chronic poisoning with Aristolochic acids, has provided convincing evidence related to BEN etiology and its clinical characteristics." 12/05/2012 - "Strong indications have been presented that dietary poisoning with aristolochic acids (AA) is responsible for Endemic Nephropathy (EN) and AA associated cancer of the upper urinary tract (UUTC). " 12/01/2015 - "Historical examples of poisoning and health issues relating to plant material containing dehydopyrrolizidine alkaloids and aristolochic acids were used as examples to demonstrate the risk and potential toxicity of herbal products, food supplements, or traditional medicines. "
4.	Drug-Related Side Effects and Adverse Reactions 06/01/2020 - "This study provides new insights into the mechanisms underlying aristolochic acids nephrotoxicity and demonstrates that AFADESI-MSI-based in situ metabolomics is a promising technique for investigation of the molecular mechanism of drug toxicity."
5.	Hepatocellular Carcinoma (Hepatoma) 11/01/2021 - "Aristolochic acids are known for nephrotoxicity, and implicated in multiple cancer types such as hepatocellular carcinomas demonstrated by recent studies. "

Related Drugs and Biologics

1.	aristolochic acid I (aristolochic acid)
2.	Lycopene
3.	Carcinogens
4.	Salts
5.	Plant Extracts
6.	DNA Adducts
7.	Tin
8.	Sulfates (Sulfates, Inorganic)
9.	Indican
10.	Humic Substances

Related Therapies and Procedures

1.	Injections
2.	Nephroureterectomy