Dynamins (Dynamin)

A family of high molecular weight GTP phosphohydrolases that play a direct role in vesicle transport. They associate with microtubule bundles (MICROTUBULES) and are believed to produce mechanical force via a process linked to GTP hydrolysis. This enzyme was formerly listed as EC 3.6.1.50.

Also Known As:

Networked: 260 relevant articles (5 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Robinson, Phillip J: 8 articles (03/2015 - 06/2006)
2.	McCluskey, Adam: 6 articles (03/2015 - 01/2009)
3.	Lipton, Stuart A: 6 articles (10/2013 - 12/2003)
4.	Scorrano, Luca: 4 articles (10/2015 - 11/2004)
5.	Sever, Sanja: 4 articles (06/2015 - 08/2007)
6.	Nakamura, Tomohiro: 4 articles (10/2013 - 04/2009)
7.	Bossy-Wetzel, Ella: 4 articles (03/2011 - 12/2003)
8.	Schwarzenbacher, Robert: 4 articles (03/2011 - 12/2003)
9.	Reynier, Pascal: 4 articles (10/2009 - 06/2003)
10.	Lenaers, Guy: 4 articles (10/2009 - 11/2005)

Related Diseases

1.	Brain Ischemia (Cerebral Ischemia) 09/04/2015 - "Mitochondrial division inhibitor (mdivi-1), a selective inhibitor of a mitochondrial fission protein dynamin-related protein 1 (Drp1), has been shown to exert protective effects in heart and cerebral ischemia-reperfusion models. " 06/01/2014 - "In the present study, we attempted to investigate the role of dynamin-related protein 1 (Drp1), a key mitochondrial fission protein, in the pathogenesis of cerebral ischemia. " 05/01/2015 - "Recent studies showed that increased mitochondrial fission is an early event of cell death during cerebral ischemia and dynamin-related protein 1 (Drp1) plays an important role in mitochondrial fission, which may be regulated by PTEN-induced putative kinase 1 (PINK1), a mitochondrial serine/threonine-protein kinase thought to protect cells from stress-induced mitochondrial dysfunction and regulate mitochondrial fission. "
2.	Parkinson Disease (Parkinson's Disease) 02/01/2015 - "Astrocytic dynamin-like protein 1 regulates neuronal protection against excitotoxicity in Parkinson disease." 12/01/2014 - "Here, we demonstrate that the mitochondrial division dynamin Drp1 and the Parkinson's disease-associated E3 ubiquitin ligase parkin synergistically maintain the integrity of mitochondrial structure and function in mouse heart and brain. " 04/15/2014 - "Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily." 01/01/2010 - "A recent article claimed that S-nitrosylation of dynamin related protein 1 (DRP1) at cysteine 644 causes protein dimerization and increased GTPase activity and is the mechanism responsible for NO-induced mitochondrial fission and neuronal injury in AD, but not in Parkinson's disease (PD). "
3.	Kidney Diseases (Kidney Disease) 06/01/2015 - "Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models." 06/01/2015 - "We found that use of the small molecule Bis-T-23, which promotes actin-dependent dynamin oligomerization and thus increased actin polymerization in injured podocytes, was sufficient to improve renal health in diverse models of both transient kidney disease and CKD. " 08/01/2007 - "Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease." 08/01/2007 - "During proteinuric kidney disease, induction of cytoplasmic cathepsin L leads to cleavage of dynamin at an evolutionary conserved site, resulting in reorganization of the podocyte actin cytoskeleton and proteinuria. "
4.	Heart Failure 07/01/2014 - "An abnormal fission process has been implicated in heart failure, and treatment with mitochondrial division inhibitor 1 (Mdivi-1), a specific inhibitor of dynamin related protein-1 (Drp-1), has been shown to improve cardiac function. " 10/23/2015 - "Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure."
5.	Heart Arrest (Cardiac Arrest) 02/01/2015 - "Post-cardiac arrest inhibition of dynamin-related protein 1 improves time to return of spontaneous circulation and myocardial hemodynamics, resulting in improved survival and neurological outcomes in a murine model of cardiac arrest. " 03/01/2015 - "Dynamin-related protein 1 as a therapeutic target in cardiac arrest." 02/01/2015 - "We hypothesized that dynamin-related protein 1 inhibition would improve survival, cardiac hemodynamics, and mitochondrial function in an in vivo model of cardiac arrest. " 02/01/2015 - "Inhibition of the mitochondrial fission protein dynamin-related protein 1 improves survival in a murine cardiac arrest model." 02/01/2015 - "Following resuscitation from cardiac arrest, mitochondrial fission was evidenced by dynamin-related protein 1 translocation to the mitochondrial membrane and a decrease in mitochondrial size. "

Related Drugs and Biologics

1.	GTP Phosphohydrolases (GTPases)
2.	Proteins (Proteins, Gene)
3.	Protein Kinases (Protein Kinase)
4.	Glycoproteins (Glycoprotein)
5.	Cathepsin L
6.	Cytochromes c (Cytochrome c)
7.	Genistein
8.	Serine (L-Serine)
9.	Guanosine
10.	Threonine (L-Threonine)

Related Therapies and Procedures

1.	Therapeutics
2.	Resuscitation
3.	Ligation
4.	Drug Therapy (Chemotherapy)