Hypoalbuminemia

A condition in which albumin level in blood (SERUM ALBUMIN) is below the normal range. Hypoalbuminemia may be due to decreased hepatic albumin synthesis, increased albumin catabolism, altered albumin distribution, or albumin loss through the urine (ALBUMINURIA).

Networked: 3552 relevant articles (112 outcomes, 219 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Proteinuria
2.	Edema (Dropsy)
3.	Anemia
4.	Hyperlipidemias (Hyperlipidemia)
5.	Hypercholesterolemia

Experts

1.	Kalantar-Zadeh, Kamyar: 16 articles (01/2021 - 07/2003)
2.	Vaziri, Nosratola D: 11 articles (01/2021 - 05/2002)
3.	Kaysen, George A: 11 articles (01/2018 - 06/2002)
4.	Kovesdy, Csaba P: 8 articles (12/2017 - 01/2009)
5.	Stenvinkel, Peter: 7 articles (01/2019 - 09/2002)
6.	Kaysen, G A: 7 articles (06/2010 - 03/2000)
7.	Wiedermann, Christian J: 6 articles (05/2022 - 04/2010)
8.	Bohl, Daniel D: 6 articles (11/2021 - 01/2016)
9.	Choi, Seung-Ho: 6 articles (12/2018 - 06/2011)
10.	Kim, Sang Yoon: 6 articles (12/2018 - 06/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypoalbuminemia:

1.	AlbuminsIBA 05/15/2009 - "[Is albumin administration beneficial in early stage of postoperative hypoalbuminemia after gastrointestinal surgery: a prospective randomized control trial]." 05/15/2009 - "To investigate whether albumin administration is beneficial in early stage of postoperative hypoalbuminemia after gastrointestinal surgery. " 11/01/2008 - "Albumin administration in the early stage of postoperative hypoalbuminemia following gastrointestinal surgery is not beneficial in correcting hypoalbuminemia or in clinical outcomes." 11/01/2008 - "Surgeons commonly see postoperative hypoalbuminemia, but whether exogenous albumin administration is beneficial for these patients is unclear. " 11/01/2008 - "Is albumin administration beneficial in early stage of postoperative hypoalbuminemia following gastrointestinal surgery?: a prospective randomized controlled trial."
2.	Proteins (Proteins, Gene)FDA Link 06/01/2004 - "Urinary protein excretion was reduced markedly, and hypoalbuminemia was also improved. " 01/01/2020 - "The present study suggested that a diet with a higher plant-based protein-total protein ratio is associated with lower all-cause and CVD mortality in PD patients, and is more significant in female and elderly patients, and those without hypoalbuminemia." 01/01/2019 - "In the present study, we investigated whether intestinal protein loss, a known reason for hypoalbuminemia, occurs in this disease. " 07/01/1990 - "Previous studies have correlated intolerance of isotonic, intact protein enteral solutions with hypoalbuminemia. " 01/01/1943 - "STUDIES ON HYPOALBUMINEMIA PRODUCED BY PROTEIN-DEFICIENT DIETS : III. THE CORRECTION OF HYPOALBUMINEMIA IN DOGS BY MEANS OF LARGE PLASMA TRANSFUSIONS."
3.	CreatinineIBA 10/01/2023 - "After adjusting for age, serum creatinine, HDL-C, AST/ALT hypoalbuminemia, LVEF and diabetes, hypoalbuminemia remained an independent predictor for long-term death (hazard ratio 1.322, 95% CI 0.046-1.670, P  = 0.019). " 03/26/2023 - "The patients who died had clinically significant high cfPWV levels; were relatively old; and had hypoalbuminemia, low creatinine levels, and diabetes. " 01/01/2023 - "Laboratory tests revealed hypoalbuminemia, increased serum creatinine and low serum C3 level. " 01/01/2022 - "Out of the patients who finished treatment, only transient grade 2 toxicities were observed during PRRT: hypoalbuminemia in 5.5% (3/55), and renal toxicity (serum creatinine and estimated glomerular filtration rate) in 1.8% (1/55). " 07/01/2019 - "Elevated serum creatinine (P = 0.0357) was the only predictor of hypoalbuminemia following multiple linear regression. "
4.	Serum AlbuminIBA 11/19/2021 - "In addition, predicting trends in serum albumin level is effective for personalized treatment of hypoalbuminemia. " 12/01/1987 - "Although several reports have acknowledged the association between hypoalbuminemia and impaired gastrointestinal absorption, no previous enteral formula has been tolerated in these acutely ill patients until serum albumin levels had improved. " 12/01/2023 - "The purpose of this study is to describe the relationship between serum albumin levels within 24 h of ultrasound and gallbladder wall thickening, and to describe the ultrasonographic features of thickened gallbladder walls in dogs with hypoalbuminemia. " 12/01/2023 - "Recent study revealed that gallbladder wall thickening in dogs with hypoalbuminemia may not be associated with serum albumin/plasma levels within 48 h of ultrasound study. " 11/04/2022 - "While studies have demonstrated an association between preoperative hypoalbuminemia and adverse clinical outcomes, the optimal serum albumin threshold for risk-stratification in the broader surgical population remains poorly defined. "
5.	Prednisolone (Predate)FDA LinkGeneric 05/01/2012 - "Treatment with oral prednisolone significantly improved his clinical symptoms and hypoalbuminemia. " 01/01/2009 - "Proteinuria and hypoalbuminemia improved, and prednisolone was tapered to 5 mg/day 9 months after the 2nd renal biopsy. " 05/01/1983 - "These results indicate that the absorption of prednisolone in patients with malabsorption is normal and that the apparently reduced bioavailability in celiac disease patients is more likely to be due to an increased volume of distribution secondary to hypoalbuminemia and reduced protein-binding." 03/01/1983 - "Reduction of the prednisolone dose is therefore not indicated in patients with portosystemic shunt and chronic liver disease, even in the presence of hypoalbuminemia." 04/22/2023 - "Proteinuria, hypoalbuminemia and generalized edema were improved after prednisolone treatment. "
6.	Furosemide (Lasix)FDA LinkGeneric 08/29/2012 - "Thus, in the situation of low glomerular filtration rate (GFR) and hypoalbuminemia, the efficacy of furosemide alone might be limited. " 03/01/2000 - "Compared with control rabbits, hypoalbuminemia decreased the natriuresis of the bolus (22.7 +/- 1.5-16.6 +/- 1.3 mmol, P <.05) but not that elicited by furosemide infusion (26.2 +/- 1.8 mmol). " 03/01/2000 - "Input rate as a major determinant of furosemide pharmacodynamics: influence of fluid replacement and hypoalbuminemia." 01/01/1992 - "The binding defect of furosemide in newborn plasma reflects either the effects of the endogenous inhibitors or of hypoalbuminemia. " 01/01/1992 - "Quantitative contribution of endogenous compounds and hypoalbuminemia in reducing the binding of furosemide in the plasma of newborn infants."
7.	Hemoglobins (Hemoglobin)IBA 06/01/2018 - "Patients with hypoalbuminemia had higher rates of renal dysfunction (26.8% vs 9.8%, P =0.0069) and hepatic dysfunction (29.3% vs 6.6%, P <0.001), and lower hemoglobin levels (11.6 vs 13.4 g/dL, P < 0.001). " 05/01/2015 - "At baseline, low hemoglobin, hypoalbuminemia and low CD4 levels were associated with a BMI < 18.5 kg/m(2). " 05/01/2011 - "Frequent adverse events were hypoalbuminemia (24%) and decrease in hemoglobin (18%), which resolved within 1 week without additional treatment. " 01/03/2022 - "Independent risk factors for postoperative AKI included hemoglobin changes, early postoperative hypoalbuminemia and intraoperative hypotension. " 01/01/2016 - "Normal hemoglobin, significant thrombocytopenia, transaminitis, and hypoalbuminemia were identified in these patients. "
8.	SteroidsIBA 04/01/2022 - "After administration of steroids relieved the abdominal symptoms and hypoalbuminemia, treatment was discontinued. " 01/01/2017 - "Previous steroids and hypoalbuminemia were associated with higher complication rates. " 01/01/2017 - "In multivariate analysis, previous steroids were associated with higher rates of surgical and medical complications, while hypoalbuminemia was associated with higher medical complication rates. " 01/01/2017 - "In univariate analysis, previous steroids, perianal CD, and stomas were considered risk factors for surgical complications, and previous steroids and hypoalbuminemia for medical complications. " 08/01/2010 - "Other associated variables were male-gender, non-Saudi nationality, smoking, steroids use, hypoalbuminemia, and the presence of extra-articular manifestations. "
9.	Prednisone (Sone)FDA LinkGeneric 10/01/2018 - "Variables associated with infectious complications in SLE patients: prednisone use (OR 1.81, 95% CI 1.13-2.90), anemia (OR 2.43, 95% CI 1.45-4.08), hypoalbuminemia (OR 2.58, 95% CI 1.55-4.30) and lymphopenia (OR 2.43, 95% CI 1.52-3.89), p < 0.05. " 01/01/2020 - "The hypoalbuminemia and EP treated successfully with the use of prednisone acetate. " 02/20/2016 - "Twenty-two (44.9%) patients who suffered from at least one short-term postoperative event had more severe hypoalbuminemia (P = 0.007) and an increased prevalence of preoperative corticosteroid usage (prednisone more than 20 mg daily or equivalent) for more than 6 weeks (59.1% vs. 25.9%, P = 0.023) compared with patients without short-term postoperative complications. " 01/01/1978 - "Nomogram for prednisone-prednisolone adjustment dose in patients with hypoalbuminemia." 01/01/2020 - "Resolution of Eosinophilic Peritonitis with Hypoalbuminemia by Oral Prednisone Acetate in an Elderly Patient Receiving Continuous Ambulatory Peritoneal Dialysis."
10.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 12/01/1998 - "Hypoalbuminemia and low serum levels of complements improved remarkably and the pleural effusion and ascites disappeared after cyclophosphamide pulse therapy four times monthly. " 12/01/2023 - "Recent reports have suggested nonconventional risk factors, such as hyperglycemia, hypoalbuminemia, prior use of antibiotics with broad anaerobic activity, posttransplant cyclophosphamide, and pulmonary impairment after RVIs. " 10/01/2014 - "Significant factors reducing infection delay were initial hypergammaglobulinemia, hypoalbuminemia, lymphopenia, as well as cyclophosphamide and methotrexate treatment. " 01/01/2005 - "This prospective cohort study examined the long-term renal function and disease relapse in adults with biopsy-proven DPLN, significant proteinuria, and hypoalbuminemia, who had been treated with sequential immunosuppression comprising prednisolone and oral cyclophosphamide as induction followed by low-dose prednisolone and azathioprine as maintenance. " 09/01/2020 - "After administration of high dose intravenous γ-globulin therapy, albumin infusion, and intravenous cyclophosphamide pulse therapy, the SRDs and severe CDs improved along with improvement in hypoalbuminemia, pleural fluid, and generalized fatigue. "

Therapies and Procedures

1.	Therapeutics 07/13/2023 - "Multivariate analysis showed that the predictors of severe AKI (stage 2 or 3) included baseline hypoalbuminemia (aOR = 2.542; 95% CI: 1.000-6.564; p-value = 0.05); concomitant use of vasopressors (aOR = 6.396; 95% CI: 2.741-15.87; p-value < 0.0001); and CMS days of therapy (DOT) prior to development of AKI ≥ 7 days (aOR = 4.728; 95% CI: 2.069-11.60; p-value < 0.0001). " 01/01/2023 - "Baseline antibody level, dialysis therapy, and hypoalbuminemia were independent predictors of impaired antibody response. " 03/05/2022 - "Baseline hypoalbuminemia and PLR could be crucial clinical assessment factors when initiating TKI therapy. " 07/01/2021 - "Notwithstanding the limitations related to the relatively small sample size, axi-cel therapy appears to overcome the adverse effect of hypoalbuminemia on OS and PFS. " 01/01/2021 - "Median time to therapy discontinuation resulting from documented toxicity was significantly shorter in those with hypoalbuminemia (22 months vs not reached; P = 0.003). "
2.	Conservative Treatment 11/01/2018 - "The possibility of PLE also needs to be considered when hypoalbuminemia occurs after conservative treatment of NOMI." 07/29/2014 - "Patients with severe hypoalbuminemia had a higher risk of conservative treatment failure, and additional management may be required." 07/29/2014 - "Severe hypoalbuminemia was independently associated with conservative management failure (p = 0.02). " 07/29/2014 - "Severe hypoalbuminemia (p = 0.003), need for emergency hemodialysis (p = 0.03), and polymicrobial infections (p = 0.04) were significantly associated with failure of conservative treatment. " 09/01/2005 - "As ascites does not seem to be related to fetal anemia or hypoalbuminemia, does not substantially change after blood transfusion and tends to resolve in late gestation, a conservative management is reasonable if fetal anemia is not severe."
3.	Length of Stay 06/01/2023 - "This study investigated the association between pre-operative severe hypoalbuminemia, in-hospital death, and length of hospital stay in patients undergoing gastrointestinal surgery. " 11/01/2023 - "Advanced age, prolonged hospital stay, dry skin, repetitive adhesive removal, low Braden Scale score, and hypoalbuminemia were associated with MARSI (p < .05). " 08/01/2023 - "Increased partial thromboplastin time and hypoalbuminemia were predictors of extended length of stay (OR, 2.283, 95% CI, 1.360-3.834, P < 0.01 and OR, 1.553, 95% CI, 1.553-1.966, P < 0.001, respectively). " 04/01/2023 - "Among procedures performed as inpatients, mean postoperative length of stay (LOS) was longer in patients with hypoalbuminemia (2.2 vs. 1.8 days; p = 0.031). " 02/22/2023 - "The current systematic review and meta-analysis showed that preoperative hypoalbuminemia was significantly associated with morbidity, length of stay, and surgical complication but not mortality."
4.	Renal Dialysis (Hemodialysis) 03/01/2009 - "The MPO study, which - unlike the HEMO study - enrolled only incident cases and not did not allow reuse of dialyzers, evaluated the mortality rate with high-flux and low-flux hemodialysis in a sicker population, i.e., patients with hypoalbuminemia, and showed a significant reduction in the relative risk of death especially in patients with diabetes. " 07/18/2023 - "During the study period, 65% of the patients died, and hypoalbuminemia and the need for hemodialysis at diagnosis were significantly associated with mortality in multivariate analysis. " 07/18/2023 - "Moreover, hypoalbuminemia and the initiation of hemodialysis at diagnosis were significantly associated with increased mortality." 01/01/2022 - "The objective of this real-world analysis was to evaluate the use and performance of four single-use (i.e., nonreuse [NR]), high-flux Optiflux dialyzers with varying surface areas (F160NR [1.5 m2], F180NR [1.7 m2], F200NR [1.9 m2], and F250NR [2.5 m2]) in patients (N = 271) with baseline hypoalbuminemia (≤3.5 g/dl) receiving hemodialysis at a medium-sized dialysis organization. " 01/01/2021 - "Hypoalbuminemia is common in hospitalized patients and is found especially frequently in patients who require KRT either for AKI or as maintenance hemodialysis. "
5.	Drug Therapy (Chemotherapy) 03/01/2023 - "In addition to the stage, the Eastern Cooperative Oncology Group Performance Status (P<0.001), NLR (P<0.001), hypoalbuminemia (P=0.02) and chemotherapy in a metastatic setting (P=0.02) were prognostic factors for OS. " 04/01/2022 - "Hypoalbuminemia observed in 25% patients was associated with significant chemotherapy delays ( p , 0.01) and interval admissions ( p , 0.03). " 01/01/2022 - "Conclusion: We have concluded that very elderly DLBCL patients aged 80 or older with hypoalbuminemia may be unfit for standard chemotherapy, regardless of other factors. " 01/01/2020 - "Hypoalbuminemia prior to starting chemotherapy in pediatric oncology patients is common (nearly half in this cohort). " 01/01/2020 - "Hypoalbuminemia prior to starting chemotherapy was present at least once in 302 (45.8%). "