Hypoalbuminemia

A condition in which albumin level in blood (SERUM ALBUMIN) is below the normal range. Hypoalbuminemia may be due to decreased hepatic albumin synthesis, increased albumin catabolism, altered albumin distribution, or albumin loss through the urine (ALBUMINURIA).

Networked: 1576 relevant articles (47 outcomes, 79 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Proteinuria
2.	Hyperlipidemias (Hyperlipidemia)
3.	Edema
4.	Anemia
5.	Hypercholesterolemia

Experts

1.	Kalantar-Zadeh, Kamyar: 10 articles (12/2015 - 07/2003)
2.	Vaziri, Nosratola D: 10 articles (10/2011 - 05/2002)
3.	Kaysen, G A: 7 articles (06/2010 - 03/2000)
4.	Kaysen, George A: 7 articles (12/2009 - 06/2002)
5.	McMillan, Donald C: 6 articles (01/2010 - 01/2004)
6.	Kovesdy, Csaba P: 5 articles (12/2015 - 01/2009)
7.	Lockhart, David: 5 articles (09/2015 - 05/2014)
8.	Mahdi, Haider: 5 articles (09/2015 - 05/2014)
9.	Liang, Kaihui: 5 articles (11/2004 - 05/2002)
10.	Moslemi-Kebria, Mehdi: 4 articles (01/2015 - 05/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypoalbuminemia:

1.	Serum AlbuminIBA 12/01/1987 - "Although several reports have acknowledged the association between hypoalbuminemia and impaired gastrointestinal absorption, no previous enteral formula has been tolerated in these acutely ill patients until serum albumin levels had improved. " 01/01/2013 - "This study was performed to identify risk factors for hypoalbuminemia (<3.8 g/dL) and the particular temporal relationship and strength of association between protein intake (nPCR) and serum albumin when confounding variables are taken into account. " 07/01/2001 - "The study design consisted of 3 groups: an experimental group, a control group of patients with mild hypoalbuminemia (HA) (serum albumin [SA] = 3.5 to 3.7 g/dL), and a comparison group of patients with moderate to severe HA (SA = 2.5 to 3.4 g/dL). " 03/01/1985 - "Serum albumin level was normalized in 11 of 12 patients who had hypoalbuminemia before the study. " 01/01/2016 - "Outcomes were compared between patients with and without hypoalbuminemia (serum albumin concentration <3.5 g/dL) with adjustment for patient and procedural factors. "
2.	CreatinineIBA 09/01/2006 - "Patients with fluid overloading and hypoalbuminemia who needed diuretic treatment were enrolled and were divided into 2 groups: the first group having clearance of creatinine (CCr) >20 ml/min, and the second group having CCr < or = 20 ml/min. FU (60 mg) mixed with HA (HA group), 60 mg FU mixed with FFP (FFP group) and water (placebo group) were given intravenously to these patients for 60 minutes in random order on the first, third and fifth day. " 01/22/2013 - "In the DC, mortality (n = 80) was higher in older patients (odds ratio [OR]: 1.3, 95% confidence interval [CI]: 1.1 to 1.7 per 10 years), those with greater hypoalbuminemia (OR: 0.49, 95% CI: 0.31 to 0.76 per mg/dl of albumin), renal dysfunction (OR: 2.1, 95% CI: 1.4 to 3.2 per mg/dl creatinine), coagulopathy (OR: 3.1, 95% CI: 1.7 to 5.8 per international normalized ratio unit), and in those receiving LVAD support at less experienced centers (OR: 2.2, 95% CI: 1.2 to 4.4 for <15 trial patients). " 06/01/2015 - "Among patients with glomerular disease, urinary protein-creatinine ratio >2mg/mg, hypoalbuminemia, and elevated blood pressure were associated with significantly reduced times to the composite event by 94%, 71%, and 67%, respectively. " 07/01/2012 - "All patients had urine protein to creatinine ratio (UPCR) of more than 1.0 g/g while ten patients had hypoalbuminemia. " 01/01/1994 - "We found hypoalbuminemia to be associated with low values for the kinetic parameters KT/V, creatinine clearance, and normalized protein catabolic rate (nPCR) by univariant analysis. "
3.	Prednisolone (Predate)FDA LinkGeneric 05/01/2012 - "Treatment with oral prednisolone significantly improved his clinical symptoms and hypoalbuminemia. " 02/01/2013 - "After prednisolone treatment, urine protein and hypoalbuminemia were markedly improved, and his leg edema disappeared. " 01/01/2009 - "Proteinuria and hypoalbuminemia improved, and prednisolone was tapered to 5 mg/day 9 months after the 2nd renal biopsy. " 03/01/1983 - "Reduction of the prednisolone dose is therefore not indicated in patients with portosystemic shunt and chronic liver disease, even in the presence of hypoalbuminemia." 09/01/2006 - "As nephrotic-range proteinuria, hypoalbuminemia, and general edema were worsening even 2 weeks after cessation of the drug, oral corticosteroid therapy (prednisolone 40 mg/day) was started. "
4.	CholesterolIBA 01/01/2015 - "inflammation was associated with changes in the total cholesterol and LDL levels and with an increased incidence of hypoalbuminemia. " 06/01/2006 - "We found a high prevalence of low BMI (<20 kg/m2), hypoalbuminemia and low total cholesterol levels, suggesting that the MS may be modified by undernutrition. " 07/01/1995 - "Serum biochemical abnormalities of low thyroid binding globulin, hypoalbuminemia, and low cholesterol, suggestive of the carbohydrate-deficient glycoprotein syndrome, were also present in both patients." 03/01/2013 - "The following factors were significantly associated with mortality at one month: cardioembolic mechanism, hypoalbuminemia, glycemia, age, low diastolic arterial pressure and Canadian Scale, at three months: previous stroke and Barthel index at discharge, at one year: previous dementia and Barthel index at three months and at five years: age, Canadian Scale score at discharge and low cholesterol at admission. " 10/01/2007 - "The nephrotic group showed heavy proteinuria, hypoalbuminemia, severe hypercholesterolemia, and normal liver tissue total and free cholesterol concentrations. "
5.	CalciumIBA 01/01/2015 - "Severe deficit was associated with hypoalbuminemia, compared with mild to moderate deficit and with sufficient values (2.98 g/dl vs. 3.52 g/dl and vs. 4.39 g/dl, respectively, p: 0.012) and low levels of serum calcium (8.35 mg/dl vs. 8.61 mg/dl and 9.8 mg/dl, respectively, p: 0.003). " 05/01/2013 - "These limitations are principally the result of the effects of hypoalbuminemia and disorders of acid-base balance on the total calcium concentration. " 04/01/2012 - "Ionized calcium should be measured in place of total serum calcium to avoid errors related to hypoalbuminemia, which is seen commonly in acutely ill patients. " 07/01/2009 - "In healthy pregnant women even during limited sun exposure time in winter, there was no need for calcium supplementation in spite of the continuous and progressive reduction of serum measured total calcium during the second and third trimesters due to dilutional hypoalbuminemia. " 01/01/2008 - "A locally derived and internally validated albumin-adjusted calcium equation differed from previously published equations and resulted in important differences in classification of calcium status in hypoalbuminemia patients. "
6.	Antinuclear AntibodiesIBA 02/01/1997 - "Impaired renal function, hypoalbuminemia, and multiple medication were observed, and antinuclear antibodies were positive in most patients. " 05/01/2012 - "Blood examination revealed extreme hypoproteinemia and hypoalbuminemia, as well as the presence of antinuclear antibodies. " 09/01/2006 - "A 24-year-old girl was referred to our hospital with generalized edema, thrombocytopenia, hypoalbuminemia, hypercholesterolemia, hypocomplementemia, antinuclear antibody (ANA) (speckled pattern) and anti- SSA/Ro positivities, and elevated CA125 antigen appeared in the blood examination. " 11/01/1997 - "We report a 82-year-old woman with adult onset Still's disease (AOSD), who presented with high fever, skin rash, swollen axillary lymph nodes, accelerated erythrocyte sedimentation rate, leukocytosis, abnormal liver function tests, hypoalbuminemia, negative antinuclear antibody and rheumatoid factor, and lack of renal involvement. " 01/01/1998 - "In group 1 the disease started with parotitis in 42.8% of cases, dysfunction of secreting epithelial glands was rare, functional activity of exocrine glands was normal, dysproteinemia (high total protein levels, hypergammaglobulinemia, hypoalbuminemia) and immunological defects (high levels of circulating immune complexes, rheumatoid factor, antinuclear factor) were more pronounced. "
7.	Rheumatoid FactorIBA 04/01/1997 - "Laboratory tests revealed hypoalbuminemia, elevated erythrocyte sedimentation rate, positive rheumatoid factor, and elevated p-ANCA. " 05/01/1990 - "An elevated erythrocyte sedimentation rate, increased C-reactive protein level, anemia, thrombocytosis, hypoalbuminemia, and a positive rheumatoid factor are common laboratory findings. " 01/01/2008 - "The laboratory studies revealed anemia, neutrophilic leukocytosis, elevated erythrocyte sedimentation rate (ESR), hypoalbuminemia, negative rheumatoid factor, pyuria, proteinuria, and the presence of HLA-B27. " 11/01/1997 - "We report a 82-year-old woman with adult onset Still's disease (AOSD), who presented with high fever, skin rash, swollen axillary lymph nodes, accelerated erythrocyte sedimentation rate, leukocytosis, abnormal liver function tests, hypoalbuminemia, negative antinuclear antibody and rheumatoid factor, and lack of renal involvement. " 01/01/1998 - "In group 1 the disease started with parotitis in 42.8% of cases, dysfunction of secreting epithelial glands was rare, functional activity of exocrine glands was normal, dysproteinemia (high total protein levels, hypergammaglobulinemia, hypoalbuminemia) and immunological defects (high levels of circulating immune complexes, rheumatoid factor, antinuclear factor) were more pronounced. "
8.	SodiumIBA 11/01/2004 - "According to this theory the primary event is the decrease in plasma volume due to the diminution of plasma oncotic pressure resulting from hypoalbuminemia, causing transfer of fluid from the plasma to the interstitial space "underfilling" the blood compartment and resulting to secondary renal sodium retention. " 07/14/2003 - "These observations challenge the conventional view attributing sodium retention in NS to a hypoalbuminemia-induced intravascular volume contraction. " 03/01/1999 - "Our purpose was to compare serum sodium levels of hospitalized adults with or without hypoalbuminemia. " 01/01/1995 - "Our data suggest that in nephrotic patients with severe hypoalbuminemia, contraction of BV plays a major role in promoting the sodium retention through the activation of compensatory hormonal mechanisms. " 11/01/1990 - "In severely jaundiced patients with hypoalbuminemia this salt losing effect is converted to salt retention by increased proximal tubular reabsorption of sodium."
9.	Lipoproteins (Lipoprotein)IBA 12/01/1996 - "Urinary protein loss related phenomena, such as hypoalbuminemia and aberrant lipoprotein profile, tend to improve also during ACE inhibitor treatment. " 07/01/1994 - "Therefore, in hypoalbuminemia and analbuminemia LPC is mainly bound to lipoproteins, which is in contrast to the paucity of LPC in these particles in normoalbuminemic rats. " 05/01/2005 - "These triglyceride-rich lipoproteins are structurally altered by interaction with HDL derived from animals with proteinuria and not as a consequence of hypoalbuminemia. " 03/01/1999 - "Increased LPC in lipoproteins may be an important factor in the disproportionate increase in cardiovascular disease in nephrotic patients with hypoalbuminemia." 09/03/1991 - "Proteinuria may lead to the lipoprotein abnormalities through stimulation of VLDL synthesis by the liver induced by hypoalbuminemia, although it has been more recently suggested that urinary protein loss is associated with the urinary loss of some important cofactor for the regulation of lipid synthesis or catabolism. "
10.	Interleukin-6 (Interleukin 6)IBA 02/01/2005 - "This study evaluated circulating plasma IL-6 as a predictor of all-cause mortality and cardiovascular mortality and studied its relationship to prevalent comorbidity and hypoalbuminemia, in a cohort of stable HD patients enrolled in the HEMO study. " 01/01/2002 - "The serum concentrations of sTNFR p80 and IL-6 were significantly higher in patients with hypoalbuminemia as compared with those with normoalbuminemia (sTNFR p80: 47.4 +/- 4.7 vs. 35.3 +/- 2.1 ng/ml, p < 0.05; IL-6: 10.8 +/- 2.0 vs. 6.3 +/- 0.5 pg/ml, p < 0.05). " 06/01/1996 - "IL-6 may be responsible for the constitution symptoms and hypoalbuminemia in these patients." 06/01/1996 - "Increasing serum levels of IL-6 correlated with constitutional symptoms (significance 0.001) and hypoalbuminemia (significance 0.007) but not with the extent of skin breakdown at vaccination sites. " 07/01/1998 - "Interleukin-6 predicts hypoalbuminemia, hypocholesterolemia, and mortality in hemodialysis patients."

Therapies and Procedures

1.	Renal Dialysis (Hemodialysis) 03/01/2009 - "The MPO study, which - unlike the HEMO study - enrolled only incident cases and not did not allow reuse of dialyzers, evaluated the mortality rate with high-flux and low-flux hemodialysis in a sicker population, i.e., patients with hypoalbuminemia, and showed a significant reduction in the relative risk of death especially in patients with diabetes. " 10/01/2015 - "Hemodialysis patients with lower S[K] and [UA] levels were characterized by hypoalbuminemia and lower nPCR, and they were associated with a long-term mortality risk." 04/01/2015 - "older age, temporary vascular access, anaemia and hypoalbuminemia are strong predictors of mortality in hemodialysis patients. " 01/01/2014 - "hypoalbuminemia is a strong and independent predictor of mortality in patients on hemodialysis. " 01/01/2014 - "Hypoalbuminemia and oxidative stress in patients on renal hemodialysis program."
2.	Catheters 01/01/2012 - "The presence of a central venous catheter and hypoalbuminemia <3.5 g/dl each explain one third of all deaths in the first 90 days." 01/01/2012 - "Use of catheter as vascular access and hypoalbuminemia <3.5 g/dl explained 34% (17-54%) and 33% (19-45%) of all deaths in the first 90 days, respectively. " 01/01/2010 - "Factors associated with death by univariate analysis included age (p < 0.0001), comorbidity (p < 0.0001), HD-Catheter (p < 0.0001), LR (p = 0.0001), hypoalbuminemia (p = 0.0011), and diabetes (p = 0.02). " 04/01/2013 - "There is a known association between low scores for quality of life (QOL) and higher rates of hospitalization, mortality in hemodialysis vascular access catheter, older age, lack of regular occupation, presence of comorbidities and hypoalbuminemia. " 04/01/2012 - "The multivariate analysis, controlled by duration of PD, identified the following independent risk factors for peritonitis: catheter replacement [p = 0.037, odds ratio (OR) 1.33, 95% confidence interval (CI) 1.02-1.73], stay in intensive care unit (p = 0.0001, OR 2.62, 95% CI 1.65-4.19), and hypoalbuminemia (p = 0.0076, OR 1.45, 95% CI 1.10-1.91). "
3.	Transplantation (Transplant Recipients) 05/01/2014 - "Hypoalbuminemia and poor growth predict worse outcomes in pediatric heart transplant recipients." 03/01/2014 - "Considerable regional variation exists in the US with respect to transplantation in children with hypoalbuminemia. " 09/01/2011 - "Our results suggest that inhibition of hepatic albumin synthesis by high dose CsA contributes to the hypoalbuminemia in renal transplant recipients." 05/27/2010 - "Hypoalbuminemia is an established predictor of poor outcome in renal transplant recipients (RTR). " 07/15/1999 - "The impact of hypoalbuminemia in kidney-pancreas transplant recipients."
4.	Drug Therapy (Chemotherapy) 10/01/2014 - "Patients with hypoalbuminemia developed more severe chemotherapy-induced toxicity symptoms. " 10/01/2014 - "Significant correlations were noted between hypoalbuminemia and CRP increase (r=0.533 P<0.05), between hypoalbuminemia and NLR≥5 (r=0.574 P<0.01) after chemotherapy. " 01/01/2014 - "Immunosuppressive drug therapy, underlying diseases, bedridden status, and hypoalbuminemia were significantly associated with indeterminate QFT-G IT test results. " 10/01/2011 - "Analyzing the risk factors for febrile neutropenia among patients who received myeloid growth factor therapy compared to those who did not, we found the incidence of comorbidities, hypoalbuminemia, advanced stage disease, and aggressive chemotherapies significantly different in the two groups. " 01/01/2010 - "Patients malnourished and with hypoalbuminemia developed more chemotherapy-induced toxicity overall when compared with those without malnutrition (31 vs 22; p = 0.02) and normal albumin (mean ranks, 62 vs 43; p = 0.002), respectively. "
5.	Plasma Exchange 01/01/1984 - "The effects due to the amount eliminated by plasma exchange were distinguished from the effects due to hypoalbuminemia. " 01/01/1988 - "Despite marked hypoalbuminemia immediately after plasma exchange, the plasma colloid osmotic pressure level fell only slightly because of the high concentration of plasma low-molecular dextran. "