Chronic Wasting Disease

A transmissible spongiform encephalopathy (prion disease) of DEER and elk characterized by chronic weight loss leading to death. It is thought to spread by direct contact between animals or through environmental contamination with the prion protein (PRIONS).

Also Known As:

Networked: 97 relevant articles (3 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Scrapie
2.	Prion Diseases (Transmissible Spongiform Encephalopathies)
3.	Bovine Spongiform Encephalopathy (Mad Cow Disease)
4.	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease)
5.	Neurodegenerative Diseases (Neurodegenerative Disease)

Experts

1.	Telling, Glenn C: 16 articles (09/2015 - 12/2004)
2.	Hoover, Edward A: 11 articles (11/2015 - 02/2006)
3.	Mathiason, Candace K: 7 articles (11/2015 - 10/2006)
4.	Balachandran, Aru: 7 articles (01/2014 - 07/2005)
5.	Prusiner, Stanley B: 6 articles (07/2015 - 11/2002)
6.	Miller, Michael W: 6 articles (09/2011 - 07/2003)
7.	Williams, Elizabeth S: 6 articles (02/2008 - 07/2003)
8.	Meyerett-Reid, Crystal: 5 articles (01/2015 - 11/2012)
9.	Sigurdson, Christina J: 5 articles (01/2014 - 02/2006)
10.	Zabel, Mark D: 5 articles (12/2013 - 01/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chronic Wasting Disease:

1.	PrionsIBA 07/01/2013 - "Could avian scavengers translocate infectious prions to disease-free areas initiating new foci of chronic wasting disease?" 01/01/2014 - "In this review we compare and contrast in vivo and in vitro evidence of the zoonotic risk to humans from sheep, cattle and deer prions, focusing primarily on chronic wasting disease and our own recent studies using protein misfolding cyclic amplification." 05/01/2010 - "We used bioassay studies of native white-tailed deer and transgenic cervidized mice to determine (i) if chronic wasting disease (CWD) blood infectivity is associated with the cellular versus the cell-free/plasma fraction of blood and (ii) in particular if B-cell (MAb 2-104(+)), platelet (CD41/61(+)), or CD14(+) monocyte blood cell phenotypes harbor infectious prions. " 12/15/2015 - "Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains." 11/01/2015 - "The presence of disease-associated prions in tissues and bodily fluids of chronic wasting disease (CWD)-infected cervids has received much investigation, yet little is known about mother-to-offspring transmission of CWD. "
2.	Codon (Codons)IBA 11/01/2006 - "To determine the transmissibility of chronic wasting disease (CWD) to sheep, 8 Suffolk lambs of various prion protein genotypes (4 ARQ/ARR, 3 ARQ/ARQ, 1 ARQ/VRQ at codons 136, 154, and 171, respectively) were inoculated intracerebrally with brain suspension from mule deer with CWD (CWDmd). " 09/01/2012 - "Diagnostic accuracy of rectal mucosa biopsy testing for chronic wasting disease within white-tailed deer (Odocoileus virginianus) herds in North America: effects of age, sex, polymorphism at PRNP codon 96, and disease progression." 08/01/2005 - "The remaining samples were surveyed for codon 225 genotype and all were characterized for chronic wasting disease (CWD) infection status. " 02/01/2008 - "The elk prion protein gene (PRNP) encodes either methionine (M) or leucine (L) at codon 132, the L132 allele apparently affording protection against chronic wasting disease (CWD). " 03/01/2013 - "In order to assess the susceptibility of bank voles to chronic wasting disease (CWD), we inoculated voles carrying isoleucine or methionine at codon 109 (Bv109I and Bv109M, respectively) with CWD isolates from elk, mule deer and white-tailed deer. "
3.	Methionine (L-Methionine)FDA Link 12/03/2007 - "A methionine/leucine polymorphism at the corresponding site in the Rocky Mountain elk PRNP gene is associated with variation in relative susceptibility and incubation time in the cervid TSE chronic wasting disease. " 02/01/2008 - "The elk prion protein gene (PRNP) encodes either methionine (M) or leucine (L) at codon 132, the L132 allele apparently affording protection against chronic wasting disease (CWD). " 03/01/2013 - "In order to assess the susceptibility of bank voles to chronic wasting disease (CWD), we inoculated voles carrying isoleucine or methionine at codon 109 (Bv109I and Bv109M, respectively) with CWD isolates from elk, mule deer and white-tailed deer. "
4.	Leucine (L-Leucine)FDA Link 12/03/2007 - "A methionine/leucine polymorphism at the corresponding site in the Rocky Mountain elk PRNP gene is associated with variation in relative susceptibility and incubation time in the cervid TSE chronic wasting disease. " 02/01/2008 - "The elk prion protein gene (PRNP) encodes either methionine (M) or leucine (L) at codon 132, the L132 allele apparently affording protection against chronic wasting disease (CWD). "
5.	SaponinsIBA 01/01/2012 - "Here, we demonstrate that PMCAb with saponin dramatically increases the sensitivity of detection for chronic wasting disease (CWD) agent without compromising the specificity of the assay (i.e., no false positive results). "
6.	Endopeptidase K (Proteinase K)IBA 01/01/2015 - "Unlike scrapie and chronic wasting disease there is no cell culture model allowing the replication of proteinase K resistant BSE (PrPBSE) and the further in vitro study of this disease. "
7.	SodiumIBA 07/01/2005 - "The purpose of this study was to enhance the sensitivity of the Western blot (WB) test for use as an alternative and confirmatory method for the diagnosis of scrapie and chronic wasting disease (CWD) in Canada by comparing 2 sample preparation procedures: an abnormal prion protein (PrPSc) concentration procedure using sodium phosphotungstic acid (PTA) precipitation and a procedure using crude sample without precipitation. " 07/01/2005 - "Evaluation of Western blotting methods using samples with or without sodium phosphotungstic acid precipitation for diagnosis of scrapie and chronic wasting disease."
8.	Serine (L-Serine)FDA Link 08/15/2007 - "To study the pathogenesis of chronic wasting disease (CWD) in deer and elk, transgenic (tg) mice were generated that expressed the prion protein (PrP) of deer containing a glycine at amino acid (aa) 96 and a serine at aa 225 under transcriptional control of the murine PrP promoter. "
9.	Phosphotungstic Acid (Acid, Phosphotungstic)IBA 07/01/2005 - "The purpose of this study was to enhance the sensitivity of the Western blot (WB) test for use as an alternative and confirmatory method for the diagnosis of scrapie and chronic wasting disease (CWD) in Canada by comparing 2 sample preparation procedures: an abnormal prion protein (PrPSc) concentration procedure using sodium phosphotungstic acid (PTA) precipitation and a procedure using crude sample without precipitation. " 07/01/2005 - "Evaluation of Western blotting methods using samples with or without sodium phosphotungstic acid precipitation for diagnosis of scrapie and chronic wasting disease."
10.	ParaffinIBA 01/01/2011 - "Formalin-fixed paraffin-embedded tissues from TSE transmission studies of scrapie in sheep, chronic wasting disease in white-tailed deer or transmissible mink encephalopathy in cattle were cut at 5 μm thickness. "

Therapies and Procedures

1.

Surgical Instruments (Clip) 05/01/2004 - "For the assessment of risk scenarios originating from these findings (e.g., alimentary transmission of pathogens associated with bovine spongiform encephalopathy [BSE] and chronic wasting disease [CWD] via tainted beef and game or iatrogenic dissemination of CJD agent through contaminated surgical instruments) more detailed information about the time course of PrP(Sc) accumulation in muscles at preclinical and clinical stages of incubation is needed. "