Adaptor Protein Complex 2

An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE.

Also Known As:

AP-2 Adaptor (Clathrin-Coated Vesicles); AP-2 Protein Complex; Adaptor-Related Protein Complex 2; HA-2 Adaptors; Hydroxyapatite 2 Adaptors; AP 2 Protein Complex; Adaptor Related Protein Complex 2; HA 2 Adaptors; Clathrin Adaptor Protein Complex 2; Clathrin Assembly Protein Complex 2

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Vesicular Transport Proteins: 1
      - Vesicular Transport Adaptor Proteins: 72
        Adaptor Protein Complex 2: 12
        alpha 2 subunit adaptor protein complex 2: 2
        Bos taurus AP2A1 protein
        C elegans Dpy-23 protein
        human AP2A1 protein
        human AP2S1 protein
        mouse Ap2s1 protein
        mu 1 subunit adaptor protein complex 2
        mu 2 subunit adaptor protein complex 2
        rat Ap2s1 protein
        S cerevisiae APS2 protein
        zebrafish ap2m1a protein

Experts

1.	Fardo, David W: 2 articles (01/2020 - 01/2020)
2.	Katsumata, Yuriko: 2 articles (01/2020 - 01/2020)
3.	Nelson, Peter T: 2 articles (01/2020 - 01/2020)
4.	Chen, Jianping: 1 article (01/2022)
5.	Ganapathy, Ashwinkumar Subramenium: 1 article (01/2022)
6.	Jia, Zhaoxing: 1 article (01/2022)
7.	Koltun, Walter: 1 article (01/2022)
8.	Lin, Lin: 1 article (01/2022)
9.	Lu, Yuwen: 1 article (01/2022)
10.	Ma, Thomas: 1 article (01/2022)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 01/01/2020 - "We recently reported evidence of Alzheimer's disease (AD)-linked genetic variation within the mucin 6 (MUC6) gene on chromosome 11p, nearby the adaptor-related protein complex 2 subunit alpha 2 (AP2A2) gene. " 01/01/2020 - "We found evidence of late-onset Alzheimer disease (LOAD)-associated genetic polymorphism within an exon of Mucin 6 (MUC6) and immediately downstream from another gene: Adaptor Related Protein Complex 2 Subunit Alpha 2 (AP2A2). "
2.	Alcoholism (Alcohol Abuse) 09/07/2023 - "Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder." 08/17/2023 - "Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder."
3.	type 1 familial Hypocalciuric hypercalcemia 10/01/2018 - "Familial hypocalciuric hypercalcemia (FHH) causes hypercalcemia by three genetic mechanisms: inactivating mutations in the calcium-sensing receptor, the G-protein subunit α11, or adaptor-related protein complex 2, sigma 1 subunit. " 03/01/2017 - "Patients with familial hyperparathyroidism and low urinary calcium excretion may have familial hypocalciuric hypercalcemia (FHH) with mutations in one of three genes: the calcium-sensing receptor (CaSR) defining FHH-type 1, the adaptor-related protein complex 2 (AP2S1) related to FHH-type 3 or the G-protein subunit alpha11 (GNA11) associated with FHH-type 2. We aimed to evaluate the presence of mutations in these genes and to identify phenotypic specificities and differences in these patients. "
4.	Chronic Obstructive Pulmonary Disease (COPD) 01/01/2020 - ": ACTB: actin beta; AKT: AKT serine/threonine kinase; ALI: air liquid interface; AP2: adaptor related protein complex 2; ATG: autophagy related; BALF: bronchoalveolar lavage fluid; COPD: chronic obstructive pulmonary disease; CXCL: C-X-C motif chemokine ligand; DOX: doxycycline; EGF: epidermal growth factor; EGFR: epidermal growth factor receptor; EPS15: epidermal growth factor receptor pathway substrate 15; HBE: human bronchial epithelial; H&E: hematoxylin & eosin; IKK: IKB kinase; IL: interleukin; LAMP2: lysosomal-associated membrane protein 2; LPS: lipopolysaccharide; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MTEC: mouse tracheal epithelial cells; MTOR: mechanistic target of rapamycin kinase; MYD88: MYD88 innate immune signal transduction adaptor; NFKB: nuclear factor of kappa B; NFKBIA: NFKB inhibitor alpha; PM: particulate matter; PtdIns3K: phosphatidylinositol 3-kinase; Rapa: rapamycin; RELA: RELA proto-oncogene, NFKB subunit; SCGB1A1: secretoglobin family 1A member 1; siRNA: small interfering RNAs; SQSTM1: sequestosome 1; TEM: transmission electronic microscopy; TLR4: toll like receptor 4; TSC2: TSC complex subunit 2."
5.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/01/2022 - ": Amil: amiloride; AP2: adaptor protein complex 2; AP2A1: adaptor related protein complex 2 subunit alpha 1; AP2M1: adaptor related protein complex 2 subunit mu 1; ATG7: autophagy related 7; CAL: calcitriol; Cas9: CRISPR-associated protein 9; Con: control; CPZ: chlorpromazine; DSS: dextran sodium sulfate; EBSS: Earle's balanced salt solution; IBD: inflammatory bowel disease; TER: trans-epithelial resistance; KD: knockdown; KO: knockout; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MβCD: Methyl-β-cyclodextrin; MET: metformin; MG132: carbobenzoxy-Leu-Leu-leucinal; MTOR: mechanistic target of rapamycin kinase; NT: non target; RAPA: rapamycin; RES: resveratrol; SMER: small-molecule enhancer 28; SQSTM1: sequestosome 1; ST: starvation; ULK1: unc-51 like autophagy activating kinase 1; WT: wild type."

Related Drugs and Biologics

1.	Mucin-6
2.	Calcium-Sensing Receptors
3.	Adaptor Protein Complex 2
4.	Sirolimus (Rapamycin)
5.	GTP-Binding Proteins (G-Protein)
6.	Proteins (Proteins, Gene)
7.	Phosphotransferases (Kinase)
8.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
9.	ErbB Receptors (EGF Receptor)
10.	Ubiquitin-Specific Proteases