Non-gestational Choriocarcinoma (Choriocarcinoma, Non gestational)

A highly malignant CHORIOCARCINOMA derived from the non-placental origin such as the totipotent cells in the TESTIS, the OVARY, and the PINEAL GLAND. It produces high levels of CHORIONIC GONADOTROPIN and can metastasize widely through the bloodstream to the lungs, brain, liver, bone, and other viscera by the time of diagnosis.

Also Known As:

Networked: 13 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Choriocarcinoma
2.	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)
3.	Carcinoma (Carcinomatosis)

Experts

1.	Asano, Ryoko: 1 article (07/2022)
2.	Furugori, Megumi: 1 article (07/2022)
3.	Sakurai, Shizuka: 1 article (07/2022)
4.	Shigeta, Hiroyuki: 1 article (07/2022)
5.	John Weroha, S: 1 article (02/2022)
6.	Kazemi, Nazanin Yeganeh: 1 article (02/2022)
7.	Langstraat, Carrie: 1 article (02/2022)
8.	Dakin, Jonathan: 1 article (09/2021)
9.	Di Palma, Silvana: 1 article (09/2021)
10.	Payne, Thomas: 1 article (09/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Non-gestational Choriocarcinoma:

1.	Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric 09/01/2021 - "A panel of immunohistochemistry studies were performed, including β-human chorionic gonadotropin, with positive findings leading to a diagnosis of extragonadal non-gestational choriocarcinoma." 01/01/2021 - "Beta-human chorionic gonadotropin levels were highest in non-gestational choriocarcinomas and alpha-fetoprotein levels were highest in malignant mixed germ cell tumors. "
2.	DNA (Deoxyribonucleic Acid)IBA 11/01/2006 - "A commercially available microsatellite DNA diagnostic assay is a quick and convenient way to discriminate between gestational and non-gestational choriocarcinoma." 10/01/2006 - "Herein is reported a case of primary pure non-gestational choriocarcinoma of the ovary in a 33-year-old nulligravid woman, as confirmed by DNA polymorphism analysis. " 10/01/2006 - "Pure non-gestational choriocarcinoma of the ovary diagnosed by DNA polymorphism analysis." 01/01/2000 - "DNA polymorphism analysis of a pure non-gestational choriocarcinoma of the ovary: case report."
3.	Sirolimus (Rapamycin)FDA Link 01/01/2023 - "Endometrial clear cell carcinoma with non-gestational choriocarcinoma differentiation: use of rapamycin maintenance."
4.	Vincristine (Oncovin)FDA LinkGeneric 09/01/2016 - "We report a case of PGC in a 56-year-old man treated with a standard non-gestational choriocarcinoma chemotherapy regimen, EMA/CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine), with a complete response and good tolerability. "
5.	Methotrexate (Mexate)FDA LinkGeneric 09/01/2016 - "We report a case of PGC in a 56-year-old man treated with a standard non-gestational choriocarcinoma chemotherapy regimen, EMA/CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine), with a complete response and good tolerability. "
6.	HLA-DR Antigens (HLA-DR)IBA 01/01/1986 - "Eight choriocarcinoma cell lines (Two SCH and IMa, were established from non-gestational choriocarcinoma and the other six BeWo, JaR, JEG-3, GCH-1, NUC-1, and HCCM-5, were from gestational one) were investigated for HLA-Class I and Class II antigen expression by the immunofluorescence method using rabbit anti HLA-ABC serum, and by a radioimmunoassay inhibition best using monoclonal antibodies (W6/32: anti HLA-ABC, 7B6: anti HLA-Class II, and D1-4-10: anti HLA-DR). "
7.	Etoposide (VP 16)FDA LinkGeneric 09/01/2016 - "We report a case of PGC in a 56-year-old man treated with a standard non-gestational choriocarcinoma chemotherapy regimen, EMA/CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine), with a complete response and good tolerability. "
8.	Dactinomycin (Actinomycin)FDA LinkGeneric 09/01/2016 - "We report a case of PGC in a 56-year-old man treated with a standard non-gestational choriocarcinoma chemotherapy regimen, EMA/CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine), with a complete response and good tolerability. "
9.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 09/01/2016 - "We report a case of PGC in a 56-year-old man treated with a standard non-gestational choriocarcinoma chemotherapy regimen, EMA/CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine), with a complete response and good tolerability. "
10.	Cisplatin (Platino)FDA LinkGeneric 01/01/2001 - "The use of cisplatin-based chemotherapy to treat non-gestational choriocarcinoma has also not been described. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 07/01/2022 - "Gestational and non-gestational choriocarcinomas differ in prognosis and sensitivity to chemotherapy due to their different etiologies. " 08/01/2000 - "A case of metastatic ovarian non-gestational choriocarcinoma: successful treatment with conservative type surgery and myeloablative chemotherapy." 10/01/2015 - "Non gestational choriocarcinoma has been found to be resistant to single-agent chemotherapy and has a worse prognosis than gestational choriocarcinoma. " 10/01/2006 - "Non-gestational choriocarcinoma has been found to be resistant to single-agent chemotherapy and has a worse prognosis than gestational choriocarcinoma, but it is difficult to distinguish the two types by routine histological examination. " 01/01/2001 - "The use of cisplatin-based chemotherapy to treat non-gestational choriocarcinoma has also not been described. "
2.	Therapeutics 11/01/2006 - "Gestational and non-gestational choriocarcinomas have distinctly different tissues of origin, parental genotypes, natural histories, and responses to therapy. "