Acro-Osteolysis (Acroosteolysis)

A condition with congenital and acquired forms causing recurrent ulcers in the fingers and toes. The congenital form exhibits autosomal dominant inheritance; the acquired form is found in workers who handle VINYL CHLORIDE. When acro-osteolysis is accompanied by generalized OSTEOPOROSIS and skull deformations, it is called HAJDU-CHENEY SYNDROME.

Also Known As:

Networked: 56 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Aggressive Periodontitis (Periodontosis)
2.	Osteosclerosis
3.	Arachnodactyly
4.	Flatfoot (Flat Feet)
5.	Pycnodysostosis

Experts

1.	Motegi, Sei-Ichiro: 2 articles (02/2015 - 11/2014)
2.	Toki, Sayaka: 2 articles (02/2015 - 11/2014)
3.	Uchiyama, Akihiko: 2 articles (02/2015 - 11/2014)
4.	Yamada, Kazuya: 2 articles (02/2015 - 11/2014)
5.	Ishikawa, Osamu: 2 articles (02/2015 - 11/2014)
6.	Hashemi-Gorji, Feyzollah: 1 article (02/2016)
7.	Yassaee, Vahid Reza: 1 article (02/2016)
8.	Khojaste, Arash: 1 article (02/2016)
9.	Toosi, Parviz: 1 article (02/2016)
10.	Ravesh, Zeinab: 1 article (02/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acro-Osteolysis:

1.	Biological Markers (Surrogate Marker)IBA 12/01/1999 - "We report a case of non-familial acro-osteolysis complicated by multiple fractures in which treatment with antiresorptive therapy improved both biochemical markers of bone turnover and bone mineral density but had no effect on the acro-osteolysis."
2.	CollagenIBA 04/01/1976 - "Collagen studies in acro-osteolysis." 11/01/2015 - "A vast number of conditions ranging from simple trauma to hereditary and collagen vascular disease had been described in association with acroosteolysis. "
3.	Vinyl Chloride (Chloroethylene)IBA 09/01/2010 - "[Acro-osteolysis caused by vinyl chloride]." 03/01/2010 - "The history of acroosteolysis was studied within the general framework of the history of the discovery of adverse health effects of exposure to vinyl chloride, and this history was studied up to the end of the 1960's. " 01/01/1988 - "Acroosteolysis and Raynaud's phenomenon after vinyl chloride exposure." 01/01/1980 - "Although three distinct types of acro-osteolysis, namely familial, idiopathic, and due to vinyl-chloride, are clearly defined, these patients did not fit into any category. " 03/01/1979 - "Occupational acroosteolysis in vinyl chloride workers in Israel."
4.	Keratosis palmoplantaris with periodontopathia and onychogryposisIBA 07/01/2010 - "Haim-Munk syndrome is an extremely rare autosomal recessive disorder of keratinization characterized clinically by palmoplantar hyperkeratosis, severe early onset periodontitis, onychogryphosis, pes planus, arachnodactyly, and acro-osteolysis. " 07/01/2010 - "Haim-Munk syndrome is an extremely rare autosomal recessive disorder characterized clinically by palmoplantar hyperkeratosis, aggressive periodontitis with severe alveolar bone destruction, onychogryphosis, pes planus, arachnodactyly, and acro-osteolysis. " 02/01/2008 - "Haim-Munk syndrome is an extremely rare autosomal recessive disorder of keratinization characterized clinically by palmoplantar hyperkeratosis, severe early onset periodontitis, onychogryphosis, pes planus, arachnodactyly, and acro-osteolysis. " 09/01/2002 - "The syndrome resembles Papillon-Lefèvre syndrome (PLS), characterized by palmoplantar keratoderma, periodontitis and psoriasis-like skin lesions, and particularly Haim-Munk syndrome, an allelic variant of PLS with acro-osteolysis. "
5.	Polyvinyl Chloride (PVC)IBA 03/01/2012 - "Acquired acro-osteolysis can manifest as a primary osteolysis syndrome and also appears in a number of disease states including rheumatologic disorders, neuropathic diseases, the result of prolonged exposure to polyvinyl chloride, and in rare cases, as a response to repeated mechanical stress. " 03/01/2010 - "[Acroosteolysis in PVC autoclave cleaners: history of an occupational disease]." 03/01/2010 - "This paper examines the history of an occupational disease which has now disappeared: acroosteolysis of manual tank cleaners in the production of polyvinyl chloride (PVC), which is a rare disease characterized by destructive alterations of the distal phalanges of the hands. " 10/01/1999 - "Several other syndromes, including acro-osteolysis, also have been associated with PVC, but less clearly with vinyl chloride. " 03/01/2010 - "In our view acroosteolysis of manual tank cleaners in PVC production is an occupational disease which is distinct from "vinyl chloride disease" as identified by Viola (1974)."
6.	Cathepsin KIBA 08/01/2014 - "Pycnodysostosis is a rare autosomal recessive disorder caused by an inactivating mutation in cathepsin K (CTSK) and characterized by dysmorphic facial features, a short stature, acroosteolysis, osteosclerosis with increased bone fragility, and delayed closure of cranial sutures. " 11/10/1998 - "Pycnodysostosis is a rare inherited osteochondrodysplasia that is caused by mutations of the cathepsin-K gene, characterized by osteosclerosis, short stature, and acroosteolysis of the distal phalanges. "
7.	Vitamin DFDA LinkGeneric 07/01/1983 - "Levels of vitamin D-metabolites in a case of acro-osteolysis syndrome." 11/01/2008 - "Significant correlations were observed between acroosteolysis and PTH (p = 0.015), calcinosis (p = 0.009), and disease duration (p = 0.008), and between PTH and vitamin D levels (p = 0.01). " 11/01/2008 - "Vitamin D, parathyroid hormone, and acroosteolysis in systemic sclerosis."
8.	trioctyl phosphine oxide (TOPO)IBA 02/01/2015 - "Male sex, dcSSc subtype, digital vasculopathy, including digital ulcers and acro-osteolysis, interstitial lung disease and rheumatoid arthritis complications were prevalent in SSc patients with RNAP and patients with Topo-I. Primary biliary cirrhosis and Sjögren's syndrome were more in SSc patients with RNAP and patients with ACA compared with patients with Topo 1. No significant difference in the frequency of complications, including Raynaud's phenomenon, pulmonary artery hypertension and malignancy was observed between the three groups. " 12/15/1994 - "Japanese SSc patients who were positive for both anti-RNAP IIO and anti-topo I Abs had a significantly higher frequency of diffuse disease, pigmentation changes, flexion contractures, and acro-osteolysis than patients having autoantibodies to topo I alone, and were diagnosed at a younger age (p < 0.05). "
9.	hydroxide ionIBA 03/01/1986 - "Cells from a patient with acroosteolysis with osteoporosis responded normally to PTH and 1,25(OH)2D3. " 07/01/1983 - "On the initial examinations of a 17-year-old boy with acro-osteolysis syndrome, the levels of serum 25-hydroxycholecalciferol (25OHD) were low, whereas serum levels of 1,25-dihydroxycholecalciferol (1,25(OH)2D) were normal. "
10.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/01/2016 - "Association of Acroosteolysis With Enhanced Osteoclastogenesis and Higher Blood Levels of Vascular Endothelial Growth Factor in Systemic Sclerosis."

Therapies and Procedures

1.	Sutures (Suture) 07/01/2014 - "It has a well characterized skeletal phenotype which include short stature, generalized increased bone density with propensity of fractures, open calvarial sutures and fontanelle, dental abnormalities, obtuse mandibular angle, resorption of lateral end of clavicle, acro-osteolysis, and in some cases visceromegaly. " 12/01/2011 - "Radiographs showed multiple impacted permanent and supernumerary teeth, hypoplastic paranasal sinuses with acro-osteolysis of terminal phalanges, and open fontanelles, and sutures along with wormian bones in the lambdoidal region." 12/01/1962 - "A syndrome of osteopetrosis, acro-osteolysis and open sutures of the skull." 12/01/1962 - "A syndrome of osteopetrosis, acro-osteolysis and open sutures of the skull." 06/01/1995 - "The clinical features, fully delineated in 1962 by Maroteaux & Lamy and by Andrén et al., include osteosclerosis, acro-osteolysis of the distal phalanges, bone fragility, clavicular dysplasia, reduced stature and skull deformities with delayed suture closure. "
2.	Amputation 01/01/2005 - "One of the patients presented with acro-osteolysis leading to auto amputation of the toes of the left foot, which required operative intervention. " 08/01/2005 - "The lesions consisted of dystrophic modifications of the fingernails, progressive sclerosis, skin thickening and ulcerations on the fingers, acro-osteolysis, and purulent inflammation with subsequent auto-amputation of the distal phalanx of the right index finger. "
3.	Kidney Transplantation 08/01/1980 - "In 19 children, renal osteodystrophy existed before kidney transplantation, which was diagnosed based on the following radiographic findings of varying frequency: rarefaction and fuzziness of the spongiosa, fraying of metaphysical ends, widening of the growth plates, subperiosteal resorption and acroosteolysis. "
4.	Renal Dialysis (Hemodialysis) 11/07/1987 - "[Treatment of chronic renal failure associated with hereditary acroosteolysis by repeated hemodialysis]."