Carbonic Anhydrase IV

A membrane-bound carbonic anhydrase found in lung capillaries and kidney.

Also Known As:

Carbonic Anhydrase 4; Carbonic Anhydrase Isozyme IV; Anhydrase 4, Carbonic

Networked: 30 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Lyases: 637
    - Carbon-Oxygen Lyases
      - Hydro-Lyases: 266
        Carbonic Anhydrases: 1704
        Carbonic Anhydrase IV: 30
        human CA4 protein
        mouse Car4 protein
        rat Ca4 protein
Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - GPI-Linked Proteins: 140
        Carbonic Anhydrase IV: 30
        human CA4 protein
        mouse Car4 protein
        rat Ca4 protein
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - GPI-Linked Proteins: 140
        Carbonic Anhydrase IV: 30
        human CA4 protein
        mouse Car4 protein
        rat Ca4 protein
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - GPI-Linked Proteins: 140
        Carbonic Anhydrase IV: 30
        human CA4 protein
        mouse Car4 protein
        rat Ca4 protein
    - Lipid-Linked Proteins: 1
      - GPI-Linked Proteins: 140
        Carbonic Anhydrase IV: 30
        human CA4 protein
        mouse Car4 protein
        rat Ca4 protein

Experts

1.	Shah, Gul N: 4 articles (04/2010 - 04/2004)
2.	Sly, William S: 4 articles (04/2010 - 04/2004)
3.	Waheed, Abdul: 4 articles (04/2010 - 04/2004)
4.	Bonapace, Giuseppe: 3 articles (03/2009 - 04/2004)
5.	Alvarez, Bernardo V: 3 articles (08/2007 - 10/2003)
6.	Casey, Joseph R: 3 articles (08/2007 - 10/2003)
7.	Supuran, Claudiu T: 2 articles (01/2021 - 10/2003)
8.	Datta, Rupak: 2 articles (04/2010 - 03/2009)
9.	Yang, Zhenglin: 2 articles (08/2007 - 01/2005)
10.	Zhang, Kang: 2 articles (08/2007 - 01/2005)

Related Diseases

1.	Adenoma (Adenomas) 01/01/2018 - "Differentiation resulted in a significant reduction in the messenger RNA level and protein expression of cystic fibrosis transmembrane conductance regulator, (CFTR) Na+/K+/2Cl- co-transporter 1 (NKCC1), and potassium channel, voltage gated, subfamily E, regulatory subunit 3 (KCNE3); and, conversely, increase of down-regulated-in-adenoma (DRA), electrogenic Na+/HCO3- co-transporter 1 (NBCe1), carbonic anhydrase 2 (CA2), and carbonic anhydrase 4 (CA4). "
2.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/01/2017 - "The present study aimed to unveil the biological role of carbonic anhydrase IV (CA IV) and its association with clinical pathological characteristics and prognostic significance in non-small cell lung cancer (NSCLC). " 10/01/2017 - "Downregulation of carbonic anhydrase IV contributes to promotion of cell proliferation and is associated with poor prognosis in non-small cell lung cancer." 01/01/2023 - "Carbonic Anhydrase 4 Serves as A Novel Prognostic Biomarker and Therapeutic Target for Non-Small Cell Lung Cancer: A Study Based on TCGA Samples." 01/01/2023 - "Carbonic anhydrase 4 (CA4) is a member of a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide and was found to have low expression in non-small cell lung cancer (NSCLC). "
3.	Neoplasms (Cancer) 06/01/2021 - "Gene set enrichment analyses and compound-disease networks revealed the targets of these metabolites to regulate important proteins associated with cancer as well as cardiovascular, urogenital, and digestive system diseases.5. Molecular docking confirmed the interactions of these six candidate bioactive metabolites with carbonic anhydrase IV, VII, and XII.6. Overall, these data offer new insights into the metabolism and pharmacological activity of I. tectorum Maxim in vivo." 01/01/2019 - "Using a murine orthotopic anaplastic astrocytoma model, ALTS1C1, this study showed that brain tumor edge had a very unique microenvironment, having higher microvascular density (MVD) and better vessel function than the tumor core, but on the other hand was also positive for hypoxia markers, such as pimonidazole (PIMO), hypoxia inducible factor-1α (HIF-1α), and carbonic anhydrase IV (CAIX). "
4.	Brain Neoplasms (Brain Tumor) 01/01/2019 - "Using a murine orthotopic anaplastic astrocytoma model, ALTS1C1, this study showed that brain tumor edge had a very unique microenvironment, having higher microvascular density (MVD) and better vessel function than the tumor core, but on the other hand was also positive for hypoxia markers, such as pimonidazole (PIMO), hypoxia inducible factor-1α (HIF-1α), and carbonic anhydrase IV (CAIX). "
5.	Astrocytoma (Pilocytic Astrocytoma) 01/01/2019 - "Using a murine orthotopic anaplastic astrocytoma model, ALTS1C1, this study showed that brain tumor edge had a very unique microenvironment, having higher microvascular density (MVD) and better vessel function than the tumor core, but on the other hand was also positive for hypoxia markers, such as pimonidazole (PIMO), hypoxia inducible factor-1α (HIF-1α), and carbonic anhydrase IV (CAIX). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Symporters
3.	Messenger RNA (mRNA)
4.	Carbonic Anhydrases (Carbonic Anhydrase)
5.	Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)
6.	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)
7.	Biomarkers (Surrogate Marker)
8.	pimonidazole
9.	Antibodies
10.	Mediator Complex Subunit 1

Related Therapies and Procedures

1.	Nephrectomy