Cellular Apoptosis Susceptibility Protein

A nucleocytoplasmic transport protein that binds to ALPHA KARYOPHERINS and RAN GTP BINDING PROTEIN inside the CELL NUCLEUS and participates in their export into CYTOPLASM. It is also associated with the regulation of APOPTOSIS and microtubule assembly.

Also Known As:

Networked: 25 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Jiang, Ming-Chung: 9 articles (10/2016 - 03/2008)
2.	Liao, Ching-Fong: 6 articles (12/2012 - 03/2008)
3.	Yeh, Kun-Tu: 5 articles (01/2015 - 05/2009)
4.	Shen, Shing-Chuan: 4 articles (01/2015 - 01/2010)
5.	Chen, Ying-Chun: 4 articles (12/2012 - 07/2008)
6.	Chang, Chun-Chao: 3 articles (06/2022 - 10/2012)
7.	Chen, Hao: 3 articles (05/2022 - 01/2018)
8.	Ye, Mei: 3 articles (05/2022 - 01/2018)
9.	Lee, Woan-Ruoh: 3 articles (01/2015 - 10/2012)
10.	Yeh, Chung-Min: 3 articles (01/2015 - 10/2012)

Related Diseases

1.	Carcinoma (Carcinomatosis) 01/01/2004 - "Expression of cellular apoptosis susceptibility protein in serous ovarian carcinoma: a clinicopathologic and immunohistochemical study." 05/01/2021 - "The CSE1L protein is expressed in human placental carcinoma cells, and its knockdown altered biological behaviours, implying that the CSE1L gene may affect human placental formation and even foetal development." 10/08/2012 - "Presence of CSE1L protein in urine of patients with urinary bladder urothelial carcinomas." 08/01/2012 - "CSE1L protein expression was not associated with 20q gain, although its expression was increased in carcinomas compared to adenomas. " 01/01/2004 - "This study investigated the expression of cellular apoptosis susceptibility protein (CAS) in serous ovarian carcinoma by immunohistochemistry and compared it with topoisomerase IIalpha (topo IIalpha), bcl-2, bcl-x, the frequency of apoptotic bodies (ABI), mitotic activity, and c-erbB-2 with regard to clinicopathologic variables. "
2.	Breast Neoplasms (Breast Cancer) 04/08/2020 - "Although several studies demonstrated cellular apoptosis susceptibility protein (CAS) involved in the development of breast cancer, the underlying mechanisms of CAS regulating cell processes in the breast cancer remain elusive. " 05/01/2022 - "Chromosome segregation 1-like (CSE1L), also called cellular apoptosis susceptibility protein (CAS), is highly expressed in breast cancer and plays a crucial role in the progression of various tumours. " 04/08/2020 - "Cellular apoptosis susceptibility protein (CAS) suppresses the proliferation of breast cancer cells by upregulated cyp24a1."
3.	Neoplasms (Cancer) 10/08/2012 - "The chromosome segregation 1-like (CSE1L) protein is highly expressed in most cancers and has been shown to be secreted by tumor cells. " 05/01/2009 - "Herein, we report that secretory CSE1L/CAS, a cellular apoptosis susceptibility protein, is a new marker for metastatic cancer. " 03/31/2008 - "CSE1L/CAS, a microtubule-associated, cellular apoptosis susceptibility protein, is highly expressed in various cancers. " 07/03/2008 - "CSE1L/CAS, the cellular apoptosis susceptibility protein, enhances invasion and metastasis but not proliferation of cancer cells." 12/06/2012 - "Here we report that chromosome segregation 1-like (CSE1L) protein is a microvesicle membrane protein and is a potential target for cancer therapy. "
4.	Colorectal Neoplasms (Colorectal Cancer) 06/01/2022 - "The chromosome segregation 1‑like (CSE1L) protein, which regulates cellular mitosis and apoptosis, was previously found to be overexpressed in colorectal cancer (CRC) cells harboring mutations. " 04/01/2010 - "Serum cellular apoptosis susceptibility protein is a potential prognostic marker for metastatic colorectal cancer."
5.	Neoplasm Metastasis (Metastasis) 07/03/2008 - "CSE1L/CAS, the cellular apoptosis susceptibility protein, enhances invasion and metastasis but not proliferation of cancer cells." 10/01/2014 - "Increased collagen XVII in adenocarcinoma (ADC) and increased caspase-9, CD44v6, and decreased cellular apoptosis susceptibility protein (CAS) and Ki-67 in squamous cell carcinoma (SCC) correlated significantly with brain metastasis. "

Related Drugs and Biologics

1.	trioctyl phosphine oxide (TOPO)
2.	Cellular Apoptosis Susceptibility Protein
3.	Vitamin D3 24-Hydroxylase
4.	Osteopontin
5.	Caspase 9
6.	Catenins
7.	Mitogen-Activated Protein Kinase 3
8.	Interleukin-6 (Interleukin 6)
9.	Cadherins (E-Cadherin)
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Therapeutics