Activin Receptors (Activin Receptor)

Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity.

Also Known As:

Networked: 423 relevant articles (13 outcomes, 49 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Oh, S Paul: 12 articles (01/2022 - 10/2003)
2.	Peng, Chun: 10 articles (01/2016 - 11/2004)
3.	Su, Hua: 8 articles (01/2022 - 12/2008)
4.	Kaplan, Frederick S: 8 articles (11/2020 - 01/2008)
5.	Ritvos, Olli: 8 articles (01/2020 - 10/2016)
6.	ten Dijke, Peter: 8 articles (01/2016 - 10/2004)
7.	Hulmi, Juha J: 7 articles (01/2021 - 10/2016)
8.	Shore, Eileen M: 7 articles (11/2020 - 01/2008)
9.	Young, William L: 7 articles (03/2014 - 02/2004)
10.	Kim, Dae-Kee: 7 articles (11/2013 - 12/2008)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Targeting the Activin Receptor Signaling to Counteract the Multi-Systemic Complications of Cancer and Its Treatments." 12/01/2020 - "Activin receptor type 2B (ACVR2B) signalling is known to cause SKM wasting, and its inhibition restores SKM mass and prolongs survival in cancer. " 01/01/2019 - "Activin receptor-like kinase 1 is associated with immune cell infiltration and regulates CLEC14A transcription in cancer." 10/15/2016 - "This increase was attributed to GSK-3β dephosphorylating, and activin receptor-like kinase 4/7 (ALK4/7) played a major role in human cancer cells. " 01/01/2016 - "Activin receptor-like kinases: a diverse family playing an important role in cancer."
2.	Anemia 01/01/2019 - "The activin receptor ligand traps are promising as treatments for anemia. " 01/01/2019 - "Activin receptor II ligand traps may represent a new paradigm for anemia treatment in MDS." 01/01/2013 - "Activin receptor antagonists for cancer-related anemia and bone disease." 12/01/2016 - "In the present review, we will discuss activin receptor ligand traps as novel therapeutic strategies particularly for sideroblastic subgroups of myelodysplastic syndromes that were recently shown to alleviate anemia by specifically inhibiting aberrant TGF-β signaling and thereby promoting erythroid differentiation." 01/01/2013 - "Antagonists of activin receptor signaling may be beneficial for cancer-related anemia and bone disease caused by malignancies such as multiple myeloma and solid tumors. "
3.	Cachexia 04/01/2014 - "In models of cancer cachexia, inhibiting type IIB activin receptors (ActRIIBs) reverse muscle wasting and prolongs survival, even with continued tumor growth. " 11/01/2020 - "In preclinical animal models, blocking activin receptor (ACVR) ligands has improved survival and prevented muscle wasting in cancer cachexia without an effect on tumour growth. " 01/01/2018 - "Cancer cachexia increases morbidity and mortality, and blocking of activin receptor ligands has improved survival in experimental cancer. " 01/01/2020 - "Coherent to the in vitro data, the use of an anti-activin receptor 2 antibody in cachectic tumour-bearing mice reduces serum levels of cancer cell-derived IL-6 by 62% (from 417 to 159 pg/mL, P = 0.03), and, importantly, it reverses cachexia and counteracts loss of all measured muscle groups (P < 0.0005). " 01/01/2019 - "Cancer-associated cachexia reduces survival, which has been attenuated by blocking the activin receptor type 2B (ACVR2B) ligands in mice. "
4.	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/01/2020 - "Biological basis for efficacy of activin receptor ligand traps in myelodysplastic syndromes." 12/01/2016 - "Activin Receptor II Ligand Traps and Their Therapeutic Potential in Myelodysplastic Syndromes with Ring Sideroblasts." 12/01/2016 - "In the present review, we will discuss activin receptor ligand traps as novel therapeutic strategies particularly for sideroblastic subgroups of myelodysplastic syndromes that were recently shown to alleviate anemia by specifically inhibiting aberrant TGF-β signaling and thereby promoting erythroid differentiation." 02/01/2018 - "Sotatercept, a novel activin-receptor fusion protein, was well tolerated and effective for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes in whom previous ESA treatment had failed. " 11/01/2016 - "Expert commentary: Sotatercept and lustatercept, two activin receptor II ligand traps that block GDF-11, are candidate drugs providing therapeutic hope in different types of ineffective erythropoiesis, including myelodysplastic syndromes (MDS) and β-thalassemia. "
5.	Hyperplasia 01/01/2023 - "Activin receptor ALK4 promotes adipose tissue hyperplasia by suppressing differentiation of adipocyte precursors." 01/01/2023 - "These results clarify the function of ALK4 in adipose tissue and highlight the contrasting roles of the two activin receptors in the regulation of adipocyte hyperplasia and hypertrophy during obesity." 09/01/2011 - "To evaluate the efficacy of an activin receptor-like kinase (ALK) 5 inhibitor, IN-1233, for the prevention of neointimal hyperplasia after bare stent placement in a rat common iliac artery (CIA) model. " 04/01/2010 - "To evaluate the efficacy of an activin receptor-like kinase-5 inhibitor, IN-1233, for the prevention of tissue hyperplasia after bare stent placement in a rat urethral model. "

Related Drugs and Biologics

1.	Ligands
2.	3- ((4- (6- methylpyridin- 2- yl)- 5- (quinolin- 6- yl)- 1H- imidazol- 2- yl)methyl)benzamide
3.	Proteins (Proteins, Gene)
4.	Phosphotransferases (Kinase)
5.	Transforming Growth Factors (Transforming Growth Factor)
6.	ACE-011
7.	ruxolitinib
8.	ActRIIA-mIgG2aFc fusion protein
9.	Activins (Activin)
10.	Inhibins (Inhibin)

Related Therapies and Procedures

1.	Stents
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)
4.	Homologous Transplantation
5.	Ovariectomy (Oophorectomy)