F2-Isoprostanes (F2 Isoprostanes)

Isoprostanes derived from the free radical oxidation of ARACHIDONIC ACID. Although similar in structure to enzymatically synthesized prostaglandin F2alpha (DINOPROST), they occur through non-enzymatic oxidation of cell membrane lipids.

Also Known As:

Networked: 380 relevant articles (10 outcomes, 48 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Roberts, L Jackson: 22 articles (02/2017 - 08/2002)
2.	Morrow, Jason D: 17 articles (09/2009 - 06/2002)
3.	Signorini, Cinzia: 15 articles (05/2022 - 11/2005)
4.	Milne, Ginger L: 12 articles (01/2022 - 01/2008)
5.	Mori, Trevor A: 10 articles (01/2019 - 10/2003)
6.	Basu, Samar: 10 articles (10/2016 - 10/2002)
7.	Montine, Thomas J: 9 articles (11/2014 - 08/2002)
8.	Il'yasova, Dora: 8 articles (06/2021 - 09/2005)
9.	Coombes, Jeff S: 8 articles (12/2020 - 03/2009)
10.	Himmelfarb, Jonathan: 7 articles (07/2018 - 03/2004)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2023 - "This was associated with a significant reduction in serum F2-isoprostane (marker of inflammation) and LC3B (marker of tissue autophagy) between the OT group compared to the AC group. " 01/01/2005 - "The availability of analytical tools for measuring F2-isoprostane biosynthesis in man has improved our understanding of the interplay between lipid peroxidation and low-grade inflammation. " 11/01/2015 - "The inflammation markers were measured in plasma using electrochemiluminescence detection-based immunoassays, and F2-isoprostanes were measured in plasma using gas chromatography-mass spectrometry. " 03/01/2008 - "F2-isoprostane, inflammation, cardiac function and oxygenation in the endotoxaemic pig." 01/01/2007 - "In conclusion, F2 isoprostane excretion is associated with patient-reported symptoms in SLE but not with measures of inflammation, SLEDAI or SLICC. "
2.	Sepsis (Septicemia) 07/01/2011 - "Plasma levels of F2-isoprostanes and isofurans are associated with renal, hepatic, and coagulation failure, but not with circulatory or pulmonary failure in severe sepsis, suggesting that lipid peroxidation is a prominent feature of septic multisystem organ failure. " 07/01/2011 - "Plasma levels of F2-isoprostanes and isofurans were measured by mass spectroscopy on intensive care unit day 2 in 50 critically ill patients with severe sepsis. " 01/01/2019 - "Urinary F2-isoprostanes, an index of oxidative stress, were not significantly changed at 24 h of sepsis but tended to transiently decrease after furosemide treatment. " 10/01/2008 - "To investigate the features of sepsis and determine the proper use of PMX-DHP, we measured the changes in levels of endocannabinoids and F2-isoprostane in patients with septic shock. " 03/01/2015 - "This trial evaluated the efficacy of acetaminophen in reducing oxidative injury, as measured by plasma F2-isoprostanes, in adult patients with severe sepsis and detectable plasma cell-free hemoglobin. "
3.	Prostatic Neoplasms (Prostate Cancer) 06/01/2011 - "F2-isoprostanes may also serve to estimate the efficacy of interventions targeting oxidative stress mechanisms in prostate cancer prevention or treatment." 10/01/2015 - "Urine F2-isoprostanes and plasma fluorescent oxidation products were not associated with prostate cancer incidence. " 06/01/2011 - "Oxidative stress measured by urine F2-isoprostane level is associated with prostate cancer." 06/01/2011 - "F2-isoprostanes were measured by gas chromatography/mass spectrometry within an age matched sample of Nashville Men's Health Study participants that included 140 patients with high grade prostatic intraepithelial neoplasia, 160 biopsy negative controls and 200 prostate cancer cases. " 06/01/2011 - "The adjusted odds of high grade prostatic intraepithelial neoplasia and prostate cancer increased with increasing F2-isoprostane quartile (p-trend = 0.015 and 0.047, respectively) and the highest F2-isoprostane quartile was associated with significantly increased odds of prostate cancer (OR 2.44, 95% CI 1.17-5.09, p = 0.017). "
4.	Schizophrenia (Dementia Praecox) 10/01/2016 - "To our knowledge, the present study is the first to assess plasma F2-isoprostane levels, the putative gold standard measure of systemic oxidative stress in vivo, in schizophrenia. " 10/01/2016 - "Previous studies found increased oxidative stress in individuals with schizophrenia, though only one study measured F2-isoprostanes and did so in urine. " 10/01/2016 - "Plasma F2-isoprostane levels were significantly higher in the schizophrenia group than in the HC group. " 10/01/2016 - "We compared plasma F2-isoprostane levels in 134 stable outpatients with schizophrenia and 120 age- and gender-matched healthy comparison (HC) subjects. " 10/01/2016 - "Elevated plasma F2-isoprostane levels in schizophrenia."
5.	Fibrosis (Cirrhosis) 01/01/1997 - "In addition, PPC provided total protection against alcohol-induced septal fibrosis and cirrhosis in the baboon and it abolished an associated twofold rise in hepatic F2-isoprostanes, a product of lipid peroxidation. " 08/12/2015 - "Liver injury and hepatic fibrosis are assessed with transient elastography (TE), Fibrometer and Hepascore, while oxidative stress is assessed by measurement of urine and serum F2-isoprostanes. " 01/01/2018 - "F2-isoprostanes can mediate bleomycin-induced lung fibrosis." 11/01/2005 - "The data provide evidence for the possibility that F2-isoprostanes generated by lipid peroxidation in hepatocytes mediate HSC proliferation and collagen production seen in hepatic fibrosis." 11/01/2005 - "In a rat model of CCl4-induced hepatic fibrosis, plasma F2-isoprostanes were markedly elevated for the entire experimental period; hepatic collagen content also increased. "

Related Drugs and Biologics

1.	C-Reactive Protein
2.	Biomarkers (Surrogate Marker)
3.	Antioxidants
4.	oxidized low density lipoprotein
5.	Glutathione Peroxidase
6.	8-Hydroxy-2'-Deoxyguanosine
7.	Vitamins
8.	Hemoglobins (Hemoglobin)
9.	Acetaminophen (Paracetamol)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Resuscitation
4.	Activities of Daily Living (ADL)
5.	Renal Dialysis (Hemodialysis)