F2-Isoprostanes (F2 Isoprostanes)

Isoprostanes derived from the free radical oxidation of ARACHIDONIC ACID. Although similar in structure to enzymatically synthesized prostaglandin F2alpha (DINOPROST), they occur through non-enzymatic oxidation of cell membrane lipids.

Also Known As:

Networked: 233 relevant articles (9 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Roberts, L Jackson: 19 articles (03/2015 - 08/2002)
2.	Morrow, Jason D: 15 articles (09/2009 - 06/2002)
3.	Montine, Thomas J: 9 articles (11/2014 - 08/2002)
4.	Mori, Trevor A: 8 articles (11/2015 - 10/2003)
5.	Basu, Samar: 8 articles (01/2015 - 07/2005)
6.	Croft, Kevin D: 7 articles (11/2015 - 10/2003)
7.	Gross, Myron D: 6 articles (11/2015 - 02/2006)
8.	Milne, Ginger L: 6 articles (01/2015 - 01/2008)
9.	Quinn, Joseph F: 6 articles (09/2014 - 08/2002)
10.	Signorini, Cinzia: 6 articles (11/2010 - 11/2005)

Related Diseases

1.	Inflammation 01/01/2005 - "The availability of analytical tools for measuring F2-isoprostane biosynthesis in man has improved our understanding of the interplay between lipid peroxidation and low-grade inflammation. " 11/01/2015 - "The inflammation markers were measured in plasma using electrochemiluminescence detection-based immunoassays, and F2-isoprostanes were measured in plasma using gas chromatography-mass spectrometry. " 03/01/2008 - "F2-isoprostane, inflammation, cardiac function and oxygenation in the endotoxaemic pig." 01/01/2007 - "In conclusion, F2 isoprostane excretion is associated with patient-reported symptoms in SLE but not with measures of inflammation, SLEDAI or SLICC. " 01/01/2005 - "In their esterified form F2-isoprostanes may be a useful criteria to evaluate the effectiveness of clinical interventions to diminish oxidant stress and associated inflammation. "
2.	Sepsis (Septicemia) 07/01/2011 - "Plasma levels of F2-isoprostanes and isofurans are associated with renal, hepatic, and coagulation failure, but not with circulatory or pulmonary failure in severe sepsis, suggesting that lipid peroxidation is a prominent feature of septic multisystem organ failure. " 07/01/2011 - "Plasma levels of F2-isoprostanes and isofurans were measured by mass spectroscopy on intensive care unit day 2 in 50 critically ill patients with severe sepsis. " 10/01/2008 - "To investigate the features of sepsis and determine the proper use of PMX-DHP, we measured the changes in levels of endocannabinoids and F2-isoprostane in patients with septic shock. " 03/01/2015 - "This trial evaluated the efficacy of acetaminophen in reducing oxidative injury, as measured by plasma F2-isoprostanes, in adult patients with severe sepsis and detectable plasma cell-free hemoglobin. "
3.	Prostatic Neoplasms (Prostate Cancer) 06/01/2011 - "F2-isoprostanes may also serve to estimate the efficacy of interventions targeting oxidative stress mechanisms in prostate cancer prevention or treatment." 10/01/2015 - "Urine F2-isoprostanes and plasma fluorescent oxidation products were not associated with prostate cancer incidence. " 06/01/2011 - "Oxidative stress measured by urine F2-isoprostane level is associated with prostate cancer." 06/01/2011 - "F2-isoprostanes were measured by gas chromatography/mass spectrometry within an age matched sample of Nashville Men's Health Study participants that included 140 patients with high grade prostatic intraepithelial neoplasia, 160 biopsy negative controls and 200 prostate cancer cases. " 06/01/2011 - "Pre-diagnosis urine F2-isoprostane level is increased in men with high grade prostatic intraepithelial neoplasia or prostate cancer, suggesting urinary F2-isoprostane provides a biomarker for the role for oxidative stress in prostate carcinogenesis. "
4.	Fibrosis (Cirrhosis) 01/01/1997 - "In addition, PPC provided total protection against alcohol-induced septal fibrosis and cirrhosis in the baboon and it abolished an associated twofold rise in hepatic F2-isoprostanes, a product of lipid peroxidation. " 01/01/2015 - "Liver injury and hepatic fibrosis are assessed with transient elastography (TE), Fibrometer and Hepascore, while oxidative stress is assessed by measurement of urine and serum F2-isoprostanes. " 11/01/2005 - "The data provide evidence for the possibility that F2-isoprostanes generated by lipid peroxidation in hepatocytes mediate HSC proliferation and collagen production seen in hepatic fibrosis." 11/01/2005 - "In a rat model of CCl4-induced hepatic fibrosis, plasma F2-isoprostanes were markedly elevated for the entire experimental period; hepatic collagen content also increased. " 07/01/2009 - "The hypothesis that F2-isoprostanes generated by lipid peroxidation in hepatocytes mediate HSC proliferation and collagen hyperproduction, seen in this experimental hepatic fibrosis, was reinforced by the demonstration, by using immunoblot analysis, that isoprostane receptors identical or analogous to those for thromboxane A2 (TxA2r) are present in HSC. "
5.	Renal Insufficiency (Renal Failure) 05/01/2001 - "Impaired clearance of esterified F2-isoprostanes may contribute to the elevated levels in renal failure. " 07/01/2011 - "Plasma F2-isoprostane levels were higher in patients who developed renal failure compared with those who did not (65 pg/mL [interquartile range {IQR} 44-112] vs. 44 pg/mL [IQR 29-54], P = 0.009) as were isofuran levels (1,223 pg/mL [IQR 348-2,531] vs. 329 pg/mL [IQR 156-1,127], P = 0.009). " 05/01/2001 - "Plasma F2-isoprostanes in diabetic ESRD patients were similar to F2-isoprostanes in patients with other causes for renal failure. "

Related Drugs and Biologics

1.	C-Reactive Protein
2.	Biological Markers (Surrogate Marker)
3.	oxidized low density lipoprotein
4.	Vitamins
5.	Acetaminophen (Paracetamol)
6.	Hemoglobins (Hemoglobin)
7.	Glutathione Peroxidase
8.	Deoxyguanosine
9.	Nitric Oxide (Nitrogen Monoxide)
10.	Autoantibodies

Related Therapies and Procedures

1.	Activities of Daily Living (ADL)
2.	Renal Dialysis (Hemodialysis)
3.	Perioperative Period
4.	Photopheresis
5.	Cardiopulmonary Resuscitation (CPR)